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161 results for “Fluoxetine”
Dataset related to article "Fluoxetine rescues rotarod motor deficits in Mecp2 heterozygous mouse model of Rett syndrome via brain serotonin"
<p><em>The file contains raw data related to the article "Fluoxetine rescues rotarod motor deficits in Mecp2 heterozygous mouse model of Rett syndrome via brain serotonin", available from </em><a href="https://doi.org/10.1016/j.neuropharm.2020.108221">https://doi.org/10.1016/j.neuropharm.2020.108221</a><em>.</em></p> <p> </p> <p><strong>Abstract of the manuscript</strong></p> <p> Motor skill is a specific area of disability of Rett syndrome (RTT), a rare disorder occurring almost exclusively in girls, caused by loss-of-function mutations of the X-linked methyl-CpG-binding protein2 (MECP2) gene, encoding the MECP2 protein, a member of the methyl-CpG-binding domain nuclear proteins family. Brain 5-HT, which is defective in RTT patients and Mecp2 mutant mice, regulates motor circuits and SSRIs enhance motor skill learning and plasticity. In the present study, we used heterozygous (Het) Mecp2 female and Mecp2-null male mice to investigate whether fluoxetine, a SSRI with pleiotropic effects on neuronal circuits, rescues motor coordination deficits. Repeated administration of 10 mg/kg fluoxetine fully rescued rotarod deficit in Mecp2 Het mice regardless of age, route of administration or pre-training to rotarod. The motor improvement was confirmed in the beam walking test while no effect was observed in the hanging-wire test, suggesting a preferential action of fluoxetine on motor coordination. Citalopram mimicked the effects of fluoxetine, while the inhibition of 5-HT synthesis abolished the fluoxetine-induced improvement of motor coordination. Mecp2 null mice, which responded poorly to fluoxetine in the rotarod, showed reduced 5-HT synthesis in the prefrontal cortex, hippocampus and striatum, and reduced efficacy of fluoxetine in raising extracellular 5-HT as compared to female mutants. No sex differences were observed in the ability of fluoxetine to desensitize 5-HT<sub>1A</sub> autoreceptors upon repeated administration. These findings indicate that fluoxetine rescues motor coordination in Mecp2 Het mice through its ability to enhance brain 5-HT and suggest that drugs enhancing 5-HT neurotransmission may have beneficial effects on motor symptoms of RTT.</p>
Prenatal treatment with the antidepressant fluoxetine on maternal and neonatal behavior in sheep
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Creatine Treatment for Female Adolescents With Depression Who Are Non-Responders to Fluoxetine or Escitalopram
ClinicalTrials.gov study NCT00851006. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Measuring Ambulation, Motor, and Behavioral Outcomes With Post-Stroke Fluoxetine in Tanzania
ClinicalTrials.gov study NCT03728153. IPD Sharing: NO. Countries: 1. Publications: 1.
Early Intervention With Fluoxetine in Autism
ClinicalTrials.gov study NCT00183339. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Fluoxetine vs CBT in Childhood Anxiety Disorders
ClinicalTrials.gov study NCT04760275. IPD Sharing: YES. Countries: 1. Publications: 1.
Pharmacological Intervention Project (Fluoxetine)
ClinicalTrials.gov study NCT00027378. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effectiveness of Fluoxetine in Young People for the Treatment of Major Depression and Marijuana Dependence
ClinicalTrials.gov study NCT00149643. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects rTMS Combined With Fluoxetine on Motor Recovery in Stroke Patients
ClinicalTrials.gov study NCT02208466. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Fluoxetine for Visual Recovery After Ischemic Stroke
ClinicalTrials.gov study NCT02737930. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Active Reference (Fluoxetine) Fixed-dose Study of Vortioxetine in Paediatric Participants Aged 7 to 11 Years With Major Depressive Disorder (MDD)
ClinicalTrials.gov study NCT02709655. IPD Sharing: Not stated. Countries: 19. Publications: 1.
Active Reference (Fluoxetine) Fixed-dose Study of Vortioxetine in Paediatric Patients Aged 12 to 17 Years With Major Depressive Disorder (MDD)
ClinicalTrials.gov study NCT02709746. IPD Sharing: Not stated. Countries: 19. Publications: 1.
Fluoxetine to Prevent Relapse and Enhance Psychological Recovery in Women With Anorexia Nervosa
ClinicalTrials.gov study NCT00288574. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Fluoxetine Mitigation Mental Health Study for Patients With Musculoskeletal Trauma
ClinicalTrials.gov study NCT04850222. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Low Dose Amisulpride Vs Olanzapine-Fluoxetine Combination in Post-Schizophrenic Depression
ClinicalTrials.gov study NCT04876521. IPD Sharing: NO. Countries: 1. Publications: 8.
Data for: Can pharmaceutical pollution alter the spread of infectious disease? A case study using fluoxetine.
<p>Human activity is changing global environments at an unprecedented rate, imposing new ecological and evolutionary ramifications on wildlife dynamics, including host-parasite interactions. Here we investigate how an emerging concern of modern human activity, pharmaceutical pollution, influences the spread of disease in a population, using the water flea <em>Daphnia</em> <em>magna</em> and the bacterial pathogen <em>Pasteuria</em> <em>ramosa</em> as a model system. We found that exposure to different concentrations of fluoxetine—a widely prescribed psychoactive drug and widespread contaminant of aquatic ecosystems—affected the severity of disease experienced by an individual in a non-monotonic manner. The direction and magnitude of any effect, however, varied with both the infection outcome measured, as well as the genotype of the pathogen. In contrast, the characteristics of unexposed animals, and thus the growth and density of susceptible hosts, were robust to fluoxetine. Using our data to parameterise an epidemiology model, we show that fluoxetine is unlikely to lead to a net increase or decrease in the likelihood of an infectious disease outbreak, as measured by a pathogen's transmission rate or basic reproductive number. Instead, any given pathogen genotype may experience a two-fold change in likely fitness, but often in opposing directions. Our study demonstrates that changes in pharmaceutical pollution give rise to complex genotype-by-environment interactions in its influence on disease dynamics, with repercussions on pathogen genetic diversity and evolution.</p>
Does Adding Oral Contraceptives to Fluoxetine Improve the Management of Premenstrual Syndrome?
ClinicalTrials.gov study NCT02562053. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Comparison of Fluoxetine Versus Citalopram Therapy to Control Postmenopausal Vasomotor Syndrome
ClinicalTrials.gov study NCT05346445. IPD Sharing: NO. Countries: 1. Publications: 41.
Dienogest Versus Luteal Phase Fluoxetine in the Management of Premenstrual Syndrome
ClinicalTrials.gov study NCT02427334. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Early Prediction of Fluoxetine Response
ClinicalTrials.gov study NCT01075529. IPD Sharing: Not stated. Countries: 1. Publications: 6.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.