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21 results for “FoxP2”
Common Genetic Variants in FOXP2 are Not Associated with Individual Differences in Language Development
<p>Three data sets used in” Common Genetic Variants <em>in FOXP2</em> Are Not Associated with Individual Differences in Language Development” are provided. The discovery data set was comprised of 834 children who were members of a Longitudinal sample and children who were members of a School sample. Both samples are contained in the Iowa data set. The Iowa data set contains a quantitative variable LCOMP that represents a composite z-score representing oral language ability. The data set also identifies which sample the children belonged to and the allele calls for 13 tag SNPs located across <em>FOXP2</em>. A second data file, ELVS, contains data from a separate sample of children who were used to test for replication of inconsistent evidence of an association between language and the SNP rs1916988. The ELVS file provides a composite oral language score scaled in standard score units (mean=100, SD=15) and the genotype calls for the SNP rs1916988.</p>
Neural FoxP2 expression in an aging open-ended vocal learner
<p>Most vocal learning species exhibit an early critical period during which their vocal control neural circuity can facilitate the acquisition of new vocalizations. Some taxa, most notably humans and parrots, retain this neurobehavioral plasticity throughout adulthood. Downregulation of the transcription factor FoxP2 in both songbird and parrot vocal control nuclei has been identified as a key expression pattern facilitating vocal learning. We hypothesize that open-ended vocal learning is vulnerable to cognitive decline, and that this deterioration will be reflected in age-related changes in neural FoxP2 expression. We tested this hypothesis in the budgerigar (<em>Melopsittacus undulatus</em>), a small gregarious parrot in which adults converge on shared call types in response to shifts in group membership. We formed novel flocks of 4 previously unfamiliar males belonging to the same age class, either "young adult" (6 mo-1 yr) or "older adult" (≥ 3 yr), and then collected audio-recordings over a 20-day learning period to assess vocal learning ability. Following behavioral recording, whole brains were extracted and immunohistochemistry was performed to measure FoxP2 protein expression in a parrot vocal learning center, the magnocellular nucleus of the medial striatum (MMSt), and its adjacent striatum. We find similarly downregulated FoxP2 expression and equivalent vocal plasticity and vocal convergence in young and older adults suggesting the maintenance of two components of open-ended learning into old age in the budgerigar. No relationship between individual variation in vocal learning measures and FoxP2 expression was detected.</p>
Neural FoxP2 expression in an aging open-ended vocal learner
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Data from: FOXP2 exhibits neuron class specific expression, but is not required for multiple aspects of cortical histogenesis
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FOXP2 regulates differential transcriptional programs in human subplate
GEO Series GSE111353. Homo sapiens. 42 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Human-specific transcriptional regulation of CNS development genes by FOXP2
GEO Series GSE18142. Pan troglodytes; Homo sapiens. 76 samples. Type: Expression profiling by array.
Polycomb Deficiency Drives a FOXP2-high Aggressive State Targetable by Epigenetic Inhibitors
GEO Series GSE154689. Mus musculus; Homo sapiens. 99 samples. Type: Expression profiling by high throughput sequencing.
Foxp2 Overexpression in BACHD mice
GEO Series GSE104990. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
β-catenin regulates FOXP2 transcriptional activity via multiple binding sites
GEO Series GSE138938. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing.
Humanized Foxp2 Accelerates Making Transitions From Declarative to Procedural Learning
GEO Series GSE60659. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Polycomb Deficiency Drives a FOXP2-high Metastatic State Targetable by Epigenetic Inhibitors
GEO Series GSE182819. Mus musculus. 7 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Cortical Foxp2 supports behavioral flexibility and developmental dopamine D1 receptor expression
GEO Series GSE130653. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Altered social behavior in mice carrying a cortical Foxp2 deletion
GEO Series GSE109596. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
FOXP2 expression was decreased in placental tissue sample of patients with preeclampsia compared with healthy pregnant women
GEO Series GSE279757. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional targets of FOXP2 in human brain and lung
GEO Series GSE8547. Homo sapiens. 8 samples. Type: Genome binding/occupancy profiling by genome tiling array.
Gene expression in striatums of Foxp2-hum, Foxp2-ko and wild-type mice
GEO Series GSE13588. Mus musculus. 71 samples. Type: Expression profiling by array.
Tubular Foxp2 promotes kidney fibrosis by regulating epithelial-mesenchymal transition and cell cycle arrest
GEO Series GSE248092. Mus musculus. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
FOXP2's impact on the primate transcriptome
GEO Series GSE100291. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Gene expression in nucleus accumbens tissue of Foxp2 heterozygous mice (S321X/+) and wild-type littermates (WT) following single cocaine or saline injection
GEO Series GSE47457. Mus musculus. 23 samples. Type: Expression profiling by array.
Expression profile of NIH3T3 cells overexpressing FOXP2 or a FOXP2 arrangement (FOXP2-CPED1)
GEO Series GSE114350. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
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