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331 results for “Frail”
Continuous Digital Monitoring of Walking Speed in Frail Elderly Patients: Noninterventional Validation Study and Longitudinal Clinical Trial (Data for independent validation study)
<p>Digital technologies and advanced analytics have drastically improved our ability to capture and interpret health relevant data from patients. However, to date, limited data and results have been published detailing real-world patient compliance, demonstrating accuracy in target indications or examining what novel insights and clinical value can be derived. Here we present novel, digital mobility data from two studies: an independent, non-interventional validation study with elderly, naturally slow walking subjects, and a global, multi-site phase IIb clinical trial involving patients with age-related muscle loss and slow walking speed (sarcopenia). Based on these data, we validate the accuracy of a novel algorithm for capturing in-clinic and real-world gait speed in frail, slow-walking adults. We demonstrate the feasibility of continuous monitoring with a wearable inertial sensor in elderly adults in real-world settings, and propose minimum thresholds for compliance required for robust capture of gait behaviors in this population. We also show how simple, inferred contextual information, describing the length of a given walking bout, can explain some of the variation in real-world gait speed, and use this information to demonstrate for the first time a relationship between in-clinic performance and real-world gait speed behavior. This work lays a foundation for exploration of the clinical relevance and value of such measures and is a first step in building a more complete chain of evidence between standardized physical performance assessment, real-world behavior, and subjective perceptions of mobility, independence and health.</p> <p>This dataset contains data collected during the independent validation study: derived data from raw accelerometry data, and summary performance data.</p> <p>The full dataset, including raw accelerometry data, is available here: <a href="https://mueller-et-al-2019.s3.amazonaws.com/index.html">https://mueller-et-al-2019.s3.amazonaws.com/index.html</a></p>
Effects of Acupunch Exercises on the Frail Older Adults in Long-Term Care Facilities
ClinicalTrials.gov study NCT04481438. IPD Sharing: NO. Countries: 1. Publications: 3.
SUPPORT FOR FRAIL ELDERLY PERSONS - From Prevention to Palliation
ClinicalTrials.gov study NCT00877058. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Comparison of the Effect of Two Interventions on Liver Frailty Index in Pre-frail and Frail Cirrhotic Patients Enlisted for Liver Transplantation
ClinicalTrials.gov study NCT06149026. IPD Sharing: YES. Countries: 1. Publications: 19.
BedMed-Frail: Does the Potential Benefit of Bedtime Antihypertensive Prescribing Extend to Frail Populations?
ClinicalTrials.gov study NCT04054648. IPD Sharing: YES. Countries: 1. Publications: 2.
Comprehensive Geriatric Assessment for Frail Older People
ClinicalTrials.gov study NCT02773914. IPD Sharing: NO. Countries: 1. Publications: 7.
CogXergaming to Promote Physical Activity and Cognitive Function in Frail Older Adults
ClinicalTrials.gov study NCT04534686. IPD Sharing: Not stated. Countries: 1. Publications: 1.
SR-WBV Training for Frail Elderly in the Skilling up Stage
ClinicalTrials.gov study NCT01704976. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Music Activities on Depression and Sleep Quality in Frail Older Adults
ClinicalTrials.gov study NCT07049445. IPD Sharing: NO. Countries: 1. Publications: 9.
Stepped Care vs Center-based Cardiopulmonary Rehabilitation for Older Frail Adults Living in Rural MA
ClinicalTrials.gov study NCT05562037. IPD Sharing: NO. Countries: 1. Publications: 20.
MoveStrong at Home: A Feasibility Study of a Model for Remote Delivery of Functional Strength and Balance Training Combined With Nutrition Education for Older Pre-frail Adults.
ClinicalTrials.gov study NCT04663685. IPD Sharing: NO. Countries: 1. Publications: 13.
Zoster Vaccine Response in the Frail Elderly
ClinicalTrials.gov study NCT01328548. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Continuum of Care for Frail Elderly People
ClinicalTrials.gov study NCT01260493. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Data from: Cost-effectiveness of a specialist geriatric medical intervention for frail older people discharged from acute medical units: economic evaluation in a two-centre randomised controlled trial (AMIGOS)
Background: Poor outcomes and high resource-use are observed for frail older people discharged from acute medical units. A specialist geriatric medical intervention, to facilitate Comprehensive Geriatric Assessment, was developed to reduce the incidence of adverse outcomes and associated high resource-use in this group in the post-discharge period. Objective: To examine the costs and cost-effectiveness of a specialist geriatric medical intervention for frail older people in the 90 days following discharge from an acute medical unit, compared with standard care. Methods: Economic evaluation was conducted alongside a two-centre randomised controlled trial (AMIGOS). 433 patients (aged 70 or over) at risk of future health problems, discharged from acute medical units within 72 hours of attending hospital, were recruited in two general hospitals in Nottingham and Leicester, UK. Participants were randomised to the intervention, comprising geriatrician assessment in acute units and further specialist management, or to control where patients received no additional intervention over and above standard care. Primary outcome was incremental cost per quality adjusted life year (QALY) gained. Results: We undertook cost-effectiveness analysis for 417 patients (intervention: 205). The difference in mean adjusted QALYs gained between groups at 3 months was -0.001 (95% confidence interval [CI]: -0.009, 0.007). Total adjusted secondary and social care costs, including direct costs of the intervention, at 3 months were £4412 (€5624, $6878) and £4110 (€5239, $6408) for the intervention and standard care groups, the incremental cost was £302 (95% CI: 193, 410) [€385, $471]. The intervention was dominated by standard care with probability of 62%, and with 0% probability of cost-effectiveness (at £20,000/QALY threshold). Conclusions: The specialist geriatric medical intervention for frail older people discharged from acute medical unit was not cost-effective. Further research on designing effective and cost-effective specialist service for frail older people discharged from acute medical units is needed.
FIGURE 2. Parapinnixa bolagnosi new species. a in Parapinnixa bolagnosi, a new species of pinnotherid crab from Cubagua Island and Los Frailes Archipelago, Venezuela (Crustacea: Brachyura: Pinnotheridae)
FIGURE 2. Parapinnixa bolagnosi new species. a, Holotype; frontal view; b-d, Paratype, b, antenae, c, abdomen; d, third maxilliped.
FIGURE 1. Parapinnixa bolagnosi new species. a in Parapinnixa bolagnosi, a new species of pinnotherid crab from Cubagua Island and Los Frailes Archipelago, Venezuela (Crustacea: Brachyura: Pinnotheridae)
FIGURE 1. Parapinnixa bolagnosi new species. a, Holotype, dorsal view; b–g, Paratype; b, cheliped, outer surface; c, cheliped, inner surface; d–g, walking legs 1–4; b–c setae removed.
FIGURE 3 in Parapinnixa bolagnosi, a new species of pinnotherid crab from Cubagua Island and Los Frailes Archipelago, Venezuela (Crustacea: Brachyura: Pinnotheridae)
FIGURE 3. Third maxilliped of Parapinnixa cf. beaufortensis sensu Werding and Müller 1990 (not, P. beaufortensis Rathbun, 1918).
FIGURE 4 in Gobiesox lanceolatus, a new species of clingfish (Teleostei: Gobiesocidae) from Los Frailes submarine canyon, Gulf of California, Mexico
FIGURE 4. Map of the Gulf of California indicating the approximate location of Bahia Los Frailes, shown in the inset. Courtesy of Google Earth.
FIGURE 3 in Gobiesox lanceolatus, a new species of clingfish (Teleostei: Gobiesocidae) from Los Frailes submarine canyon, Gulf of California, Mexico
FIGURE 3. Drawings of Gobiesox lanceolatus SIO 65-34, holotype, 39.8 mm SL, in dorsal (above) and lateral (below) view (artist unknown).
FIGURE 5 in Gobiesox lanceolatus, a new species of clingfish (Teleostei: Gobiesocidae) from Los Frailes submarine canyon, Gulf of California, Mexico
FIGURE 5. Diving saucer Soucoupe at Bahia Los Frailes, Baja California Sur, Mexico, 1965. Courtesy of SIO Archives.
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