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206 results for “Functional MRI”

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zenodo52/100

functional MRI study on the language stress perception in a foreign language

<p>fMRI dataset of 91 participants during a linguistic task about language stress perception in a foreign language.</p> <p>Participants listened to pairs of words in a foreign language (Spanish) and had to indicate if the words were the same or different. The different pairs differed either by the stress pattern, or by the final vowel.</p> <p>This dataset was divided into two groups: 51 participants with French as native language and 40 with Swiss-German as native language. None of the participants had knowledge of Spanish.</p> <p>This repository respects the BIDS standard (<a href="https://bids.neuroimaging.io/">https://bids.neuroimaging.io/</a>), including all the raw data (func, fmap, anat) and metadata in order to reproduce the processing.</p> <p>These data have been used in two papers:</p> <p>S. Schwab, M. Mouthon, L.B. Jost, J. Salvadori, I. Yakoub, E. Ferreira da Silva, N. Giroud, B. Perriard and J.M. Annoni, Neural correlates of lexical stress processing in a foreign free-stress language; Brain and Behavior (2023)</p> <p>L. Rogenmoser, M. Mouthon, F. Etter, J. Kamber, J.M. Annoni and S. Schwab; The processing of stress in a foreign language modulates functional antagonism between default mode and attention network regions, (submitted)</p>

opencc-by-4.0Dec 2022View details →
OpenNeuro48/100

Human es-fMRI Resource: Concurrent deep-brain stimulation and whole-brain functional MRI

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openCC0Jan 2020View details →
OpenNeuro48/100

Effects of Phase Regression on High-Resolution Functional MRI of the Primary Visual Cortex

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openCC0Jan 2020View details →
zenodo48/100

Functional MRI data from medetomidine-isoflurane anesthetized marmosets

<p>This dataset contains unprocessed&nbsp;<strong>functional MRI (fMRI)</strong> data acquired in&nbsp;&nbsp;<strong>common marmosets</strong> (<em>Callithrix jacchus</em>), The data were obtained during a continuous infusion of the sedative <strong>medetomidine</strong>, supplemented with a low concentration of <strong>isoflurane</strong>. All experiments were carried out in accordance with the guidelines from &nbsp;Directive 2010/63/EU of the European Parliament on the protection of animals used for scientific purposes.</p> <p><strong>Related paper</strong></p> <p>This dataset supplements the following <a href="https://www.biorxiv.org/content/10.1101/2023.11.21.568138v1.abstract">manuscript</a>.</p> <p><strong>Preserving functional network structure under anesthesia in the marmoset monkey brain</strong></p> <p>M Ortiz-Rios, N Sirmpilatze, J Koenig, S Boretius - bioRxiv, 2023</p> <p><strong>doi: <a href="https://doi.org/10.1101/2023.11.21.568138">https://doi.org/10.1101/2023.11.21.568138</a> </strong></p> <p><strong>Data structure</strong></p> <p>The main data files are organized into eight zipped folders - <em><strong>sub-02.tar.gz, .... sub-09.tar.gz </strong></em>&nbsp;- each&nbsp;constituting a dataset formatted according to the&nbsp;<a href="https://bids.neuroimaging.io/">Brain Imaging Data Structure</a>&nbsp;specifications (BIDS v1.6.0).</p> <ul> <li>Each BIDS-formatted dataset contains subfolders for individual sessions (e.g. <em><strong>ses-0001</strong>, </em>etc.).Additionally, a text file,&nbsp;<strong><em>participants.tsv</em></strong>,&nbsp;with some essential information about the subjects (e.g. age, weight, sex).</li> <li>Each subject-specific folder&nbsp;contains subfolders named <em><strong>func</strong> </em>and <strong><em>anat</em></strong>, storing fMRI and structural MRI data respectively. The (f)MRI data are provided in <a href="https://nifti.nimh.nih.gov/">NIfTI format</a> (suffixed with <strong><em>.nii.gz</em></strong>).&nbsp;</li> <li>The <em><strong>func</strong></em> files are named as <strong><em>{sub-id}_{ses-id}_{run-id}_{task-id}_bold.nii.gz. </em></strong>The task id is based on runs acquired for resting-state or during visual stimulation.</li> </ul> <p><strong>BIDS-formatted dataset</strong></p> <p>The basic characteristics of the datasets are given below. More details can be found in the <a href="https://www.biorxiv.org/content/10.1101/2023.11.21.568138v1.abstract">preprint</a>.</p> <ol> <li><em><strong>Marmoset</strong></em> <ul> <li><strong>Institution:<em> </em></strong>German Primate Center (Deutsches Primatenzentrum GmbH - Leibniz-Institut f&uuml;r Primatenforschung), G&ouml;ttingen, Germany</li> <li><strong>MR&nbsp;system:</strong> Bruker BioSpec 9.4 T, equpped with B-GA 20S gradient</li> <li><strong>Anatomical MRI scan:</strong> Proton density-weighted (PDw) with magnetization transfer (MT) pulse, 1 per subject</li> <li><strong>fMRI scan:</strong> GE-EPI, several runs per subject (between 6 and 9 runs), duration 330 s for visual runs and 600 s for resting-state runs, all with a TR of 2 s and a resolution of 0.4 mm isotropic.</li> <li><strong>Subjects:</strong> 8&nbsp;<em>Callithrix jacchus</em></li> <li><strong>Age range:</strong> 2.6 - 9.5 years</li> <li><strong>Weight range:</strong> 375 - 517 g</li> <li><strong>Sex:</strong> 5 males and 3 females</li> <li><strong>Ethics oversight:</strong> Lower Saxony State Office for Consumer Protection and Food Safety, Hannover, Germany (approval numbers 33.19-42502-04-17/2496)</li> </ul> </li> </ol>

opencc-by-4.0Apr 2024View details →
zenodo48/100

Dataset Comparison of MRI-based automated segmentation methods and functional neurosurgery targeting with direct visualization of the Ventro-intermediate thalamic nucleus at 7T

<p>Scientific Reports - Nature - DOI : 10.1038/s41598-018-37825-8</p> <p>##################################<br> &quot;Comparison of MRI-based automated segmentation methods and functional neurosurgery targeting with direct visualization of the Ventro-intermediate thalamic nucleus at 7T&quot;<br> ##################################</p> <p>E. Najdenovska*, C. Tuleasca*, J. Jorge, P. Maeder, J.P. Marques, T. Roine, &nbsp;D. Gallichan, J.-P. Thiran, M. Levivier, and M. Bach Cuadra</p> <p>*Equally contributed authors</p> <p><br> Copyright (c) - All rights reserved. University of Lausanne. 2018.</p> <p><br> To reproduce the analyses presented in the referred study, in this repository you could find the MR images acquired from nine young healthy subjects (YS1-YS5), four elderly healthy subject (ES1-ES4) and two drug-resistant tremor patients treated treated with Vim radiosurgery by Gamma Knife (P1 and P2).</p> <p>The provided dataset includes the following NifTI files:</p> <p>- MPRRAGE @3T<br> - DWI @3T (together with the corresponding bvals and bvecs)<br> - MP2RAGE @7T<br> - SWI @7T<br> - binary masks of the manual delineation of both left and right Vim respectively that were done on the SWI (as NifTI files as well).</p> <p>Additionally, for the young cohort (YS1-YS5) we include as well the images used for building the quadrilateral of Guiot:<br> - T2-w @3T<br> - T2 CISS @3T</p> <p>For the patients (P1 and P2), a follow-up MPRAGE (acquired at 3T) with Gadolinium enhancement is also provided.</p> <p>&mdash;&mdash;&mdash;&mdash;&mdash;&mdash;&mdash;&mdash;&mdash;&mdash;&mdash;&mdash;&mdash;&mdash;<br> Notes:<br> 1. For YS3 MP2RAGE at 7T is missing, instead MPRAGE at 3T was used</p> <p>2. The code performing the thalamic nuclei clustering could be found in Zenodo (DOI: 10.5281/zenodo.123768)</p>

opencc-by-sa-4.0May 2018View details →
zenodo48/100

CROSS-VALIDATION OF FUNCTIONAL MRI and PARANOID-DEPRESSIVE SCALE: BRAIN SIGNATURES FROM MULTIVARIATE ANALYSIS

<p>Brain signatures identified by bottom-up unsupervised machine learning: three principal components based on activations yielded from the three kinds of diagnostically relevant stimuli are used in order to produce cross-validation markers which may effectively predict the variance on the level of clinical populations and eventually delineate diagnostic and classification groups.&nbsp; The stimuli represent items from a paranoid-depressive self-evaluation scale, administered simultaneously with functional magnetic resonance imaging (fMRI).</p> <p>We have been able to separate the two investigated clinical entities &ndash; schizophrenia and recurrent depression by use of multivariate linear model and principal component analysis. This is a confirmation of the possibility to achieve bottom-up classification of mental disorders, by use of the brain signatures relevant to clinical evaluation tests.</p>

opencc-by-4.0Oct 2019View details →
OpenNeuro44/100

Repetition of Computer Security Warnings Results in Differential Repetition Suppression Effects as Revealed with Functional MRI

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openCC0Jan 2020View details →
OpenNeuro44/100

Deciphering the scopolamine rat model by preclinical functional MRI

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openCC0Jan 2021View details →
zenodo44/100

Functional MRI data from isoflurane-anesthetized macaques, marmosets, and rats

<p>This dataset contains unprocessed task-free&nbsp;<strong>functional MRI (fMRI)</strong> data acquired in three different mammalian species: <strong>long-tailed macaques</strong> (<em>Macaca fascicularis</em>), <strong>common marmosets</strong> (<em>Callithrix jacchus</em>), and <strong>rats</strong> (<em>Rattus Norvegicus</em>, Wistar strain). The data&nbsp;were obtained during <strong>isoflurane anesthesia</strong>, with the animals intubated and mechanically ventilated.&nbsp;All experiments were carried out in accordance with the guidelines from &nbsp;Directive 2010/63/EU of the European Parliament on the protection of animals used for scientific purposes.</p> <p><strong>Related paper</strong></p> <p>This dataset supplements&nbsp;the following <a href="http://doi.org/10.7554/eLife.74813">manuscript</a>:</p> <p>Sirmpilatze N, Mylius J, Ortiz-Rios M, Baudewig J, Paasonen J, Golkowski D, Ranft A, Ilg R, Gr&ouml;hn O, Boretius S. <em>Spatial signatures of anesthesia-induced burst-suppression differ between primates and rodents.</em>&nbsp;eLife 2022;11:e74813. DOI: https://doi.org/10.7554/eLife.74813</p> <p><strong>Data structure</strong></p> <p>The main data&nbsp;files are&nbsp;organized into four zipped folders - <em><strong>Macaque.zip, Marmoset.zip, Rat1.zip, Rat2.zip</strong></em> - each&nbsp;constituting a dataset formatted according to the&nbsp;<a href="https://bids.neuroimaging.io/">Brain Imaging Data Structure</a>&nbsp;specifications (BIDS v1.6.0).</p> <ul> <li>Each BIDS-formatted dataset contains subfolders for individual subjects (e.g. <em><strong>sub-01</strong>, <strong>sub-02</strong>,</em> etc.), as well as a tab-separated text file,&nbsp;<strong><em>participants.tsv</em></strong>,&nbsp;with some essential information about the subjects (e.g. age, weight, sex).</li> <li>Each subject-specific folder&nbsp;contains subfolders named <em><strong>func</strong> </em>and <strong><em>anat</em></strong>, storing fMRI and structural MRI data respectively. The (f)MRI data are provided in <a href="https://nifti.nimh.nih.gov/">NIfTI format</a> (suffixed with <strong><em>.nii.gz</em></strong>).&nbsp;Each NIfTI file is accompanied by a <strong><em>.json sidecar</em></strong>&nbsp;holding&nbsp;metadata.</li> <li>The <em><strong>func</strong></em> subfolders also include tab-separated text&nbsp;files named&nbsp;as <strong><em>{sub-id}_scans.tsv</em></strong> (e.g. <em><strong>sub-01_scans.tsv</strong></em>). These files provide additional information&nbsp;on the fMRI runs within the <em><strong>func</strong></em> subfolder, such as the isoflurane concentration during the acquisition of the fMRI run, duration of the run, etc.</li> <li>The column names in <em><strong>participants.tsv</strong></em> and <em><strong>{sub-id}_scans.tsv</strong></em> files are explained in accompanying <em><strong>participants.json </strong></em>and <em><strong>{sub-id}_scans.json</strong></em>&nbsp;files.</li> </ul> <p><strong>BIDS-formatted datasets</strong></p> <p>The basic characteristics of the datasets are given below. More details&nbsp;can be found in the <a href="https://www.biorxiv.org/content/10.1101/2021.10.15.464515">preprint</a>.</p> <ol> <li><em><strong>Macaque</strong></em> <ul> <li><strong>Institution:<em> </em></strong>German Primate Center (Deutsches Primatenzentrum GmbH - Leibniz-Institut f&uuml;r Primatenforschung), G&ouml;ttingen, Germany</li> <li><strong>MR&nbsp;system:</strong> Siemens MAGNETOM Prisma 3T</li> <li><strong>Anatomical MRI scan:</strong> T1-weighted (MPRAGE), 1 per subject</li> <li><strong>fMRI scan:</strong> GE-EPI, 1 or 2 runs per subject, run duration 600 - 1200 s</li> <li><strong>Subjects:</strong>&nbsp;13 <em>Macaca fascicularis</em></li> <li><strong>Age range:</strong> 6.8 - 19.8 years</li> <li><strong>Weight range:</strong> 3.6 - 8.1 kg</li> <li><strong>Sex:</strong> all females</li> <li><strong>Ethics oversight:</strong>&nbsp;Lower Saxony State Office for Consumer Protection and Food Safety, Hannover, Germany (approval number&nbsp;33.19-42502-04-16/2278)</li> </ul> </li> <li><em><strong>Marmoset</strong></em> <ul> <li><strong>Institution:<em> </em></strong>German Primate Center (Deutsches Primatenzentrum GmbH - Leibniz-Institut f&uuml;r Primatenforschung), G&ouml;ttingen, Germany</li> <li><strong>MR&nbsp;system:</strong> Bruker BioSpec 9.4 T, equpped with B-GA 20S gradient</li> <li><strong>Anatomical MRI scan:</strong> Proton density-weighted (PDw) with magnetization transfer (MT) pulse, 1 per subject</li> <li><strong>fMRI scan:</strong> GE-EPI, 1 run per subject, run duration 600 s (except for sub-21, containing 4 runs of 300 s duration each).</li> <li><strong>Subjects:</strong> 21 <em>Callithrix jacchus</em></li> <li><strong>Age range:</strong>&nbsp;1.9&nbsp;- 14.2&nbsp;years</li> <li><strong>Weight range:</strong> 337&nbsp;- 517 g</li> <li><strong>Sex:</strong>&nbsp;11 females</li> <li><strong>Ethics oversight:</strong>&nbsp;Lower Saxony State Office for Consumer Protection and Food Safety, Hannover, Germany (approval numbers 33.19-42502-04-17/2496 and 33.19-42502-04-17/2535)</li> </ul> </li> <li><em><strong>Rat1</strong></em> <ul> <li><strong>Institution:<em> </em></strong>German Primate Center (Deutsches Primatenzentrum GmbH - Leibniz-Institut f&uuml;r Primatenforschung), G&ouml;ttingen, Germany</li> <li><strong>MR&nbsp;system:</strong> Bruker BioSpec 9.4 T, equpped with B-GA 12S2 gradient</li> <li><strong>Anatomical MRI scan:</strong>&nbsp;T2-weighted (TurboRARE), 1 per subject</li> <li><strong>fMRI scan:</strong>&nbsp;GE-EPI, 6 runs per subject (except for sub-10: 4 runs), run duration 720&nbsp; s</li> <li><strong>Subjects:</strong>&nbsp;11 <em>Rattus norvegicus</em>, Wistar strain</li> <li><strong>Weight range:</strong>&nbsp;350&nbsp;- 450&nbsp;g</li> <li><strong>Sex:</strong>&nbsp;all females</li> <li><strong>Ethics oversight:</strong>&nbsp;Lower Saxony State Office for Consumer Protection and Food Safety, Hannover, Germany (approval number&nbsp;33.19-42502-04-15/2042)</li> </ul> </li> <li><em><strong>Rat2</strong></em> <ul> <li><strong>Institution:<em> </em></strong>A.I.V. Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland</li> <li><strong>MR&nbsp;system:</strong> Bruker PharmaScan&nbsp;7&nbsp;T</li> <li><strong>Anatomical MRI scan:</strong> NOT provided</li> <li><strong>fMRI scan:</strong> GE-EPI, 6 runs per subject (except for sub-10: 4 runs), run duration 720&nbsp; s</li> <li><strong>Subjects:</strong>&nbsp;6&nbsp;<em>Rattus norvegicus</em>, Wistar strain</li> <li><strong>Weight range:</strong>&nbsp;265&nbsp;- 350&nbsp;g</li> <li><strong>Sex:</strong>&nbsp;all males</li> <li><strong>Ethics oversight:</strong>&nbsp;Animal Ethics Committee of the Provincial Government of Southern Finland</li> </ul> </li> </ol> <p><strong>Example data</strong></p> <p>Before you commit to downloading the BIDS-formatted datasets, we encourage you to examine the&nbsp;example data that we provide in the root folder. These include one anatomical (stuctural MRI) and one functional (fMRI) scan from each of the four datasets (Rat2 contains functional scans only), with their respecitve <strong><em>.json sidecars</em></strong>. A preview of these example scans is provided by <em><strong>0_preview.pdf.</strong></em></p>

opencc-by-4.0Oct 2021View details →
zenodo40/100

Macaca mulatta and Macaca fascicularis anatomical and functional MRI data

<p>&nbsp;</p> <p>The&nbsp;ION dataset includes anatomical, field map, and fMRI data from 8 monkeys: 4 <em>Macaca mulatta</em>&nbsp;and 4&nbsp;<em>Macaca fascicularis.</em></p> <p>The data is provided both as a directory structure compressed as <code>all_the_data.zip</code>, and as individual files. The correspondence between the directory structure and the individual files is contained in the file <code>tree.json</code>. The bash command <code>source unflatten.sh</code> can be used to convert the individual files into the original directory structure.</p> <p><strong>Scanner Specifications</strong></p> <ul> <li>Siemens Tim Trio 3T whole-body scanner with or without head-only gradient insert (Siemens AC88)</li> <li>8-channel phased-array transceiver coils</li> <li>Optimization of the magnetic field prior to data acquisition: Manual shimming</li> </ul> <p><strong>Sample Description</strong></p> <ul> <li>Sample size: 8</li> <li>Age distribution: 3.80-5.99 years</li> <li>Weight distribution: 5.0-10.2 kg</li> <li>Sex distribution: 7 male, 1 female</li> </ul> <p>Click&nbsp;<a href="http://fcon_1000.projects.nitrc.org/indi/PRIME/files/ion.csv">here</a>&nbsp;for the full sample description (.csv download)</p> <p><strong>Scan Procedures and Parameters</strong></p> <p><em>Ethics approval:</em>&nbsp;All experimental procedures for nonhuman primate research were approved by the Institutional Animal Care and Use Committee in the Institute of Neuroscience and by the Biomedical Research Ethics Committee, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and conformed to National Institutes of Health guidelines for the humane care and use of laboratory animals.</p> <p><em>Animal care and housing:</em>&nbsp;Animals were housed in single cage</p> <p><em>Any applicable training:</em>&nbsp;none</p> <p><strong>Scanning preparations</strong></p> <p><em>Anesthesia procedures:</em>&nbsp;Anesthesia of the animals was inducted with an intramuscular injection of a cocktail of dexmedetomidine (18 - 30 &micro;g/kg) and midazolam (0.2 - 0.3 mg/kg), supplemented with atropine sulfate (0.05 mg/kg). After intubation, anesthesia was maintained using the lowest possible concentration of isoflurane gas via a MRI-compatible ventilator.</p> <p><em>Time between anesthesia and scanning:</em>&nbsp;Scanning lasted about 1.5 hours after induction.</p> <p><em>Head fixation:</em>&nbsp;Custom-built MRI-compatible stereotaxic frame</p> <p><em>Position in scanner and procedure used:</em>&nbsp;Sphinx position</p> <p><em>Contrast agent:</em>&nbsp;none</p> <p><strong>During scanning</strong></p> <p><em>Physiological monitoring:</em>&nbsp;Physiological parameters including blood oxygenation, ECG, rectal temperature, respiration rate and end-tidal CO<sub>2</sub>&nbsp;were monitored. Oxygen saturation was kept over 95%.</p> <p><em>Additional procedures:</em>&nbsp;Animals were ventilated by a MRI-compatible ventilator. Body temperature was kept constant using hot water blanket.</p> <p><strong>Scan sequences</strong></p> <ul> <li>Resting-state: <ul> <li>Gradient-echo EPI</li> <li>TR: 2000ms</li> <li>TE: 29ms</li> <li>Flip angle: 77&deg;</li> <li>Field of view: 96 x 96 mm</li> <li>In plane resolution: 1.5 x 1.5 mm</li> <li>Slices number: 32</li> <li>Slice thickness: 2.5mm</li> <li>GRAPPA factor: 2</li> <li>Measurements: 200</li> <li>Slice direction: Coronal slice</li> </ul> </li> <li>Structural: <ul> <li>T1 MPRAGE Sequence</li> <li>Voxel resolution: 0.5 x 0.5 x 0.5 mm</li> <li>TE: 3.12ms</li> <li>TR: 2500ms</li> <li>TI: 1100ms</li> <li>Flip angle: 9&deg;</li> <li>Slice direction: 44 sagittal slices</li> <li>Number of averages: 2</li> </ul> </li> <li>Additional: <ul> <li>Field map: a pair of gradient echo images</li> <li>TE1: 4.22ms</li> <li>TE2: 6.68ms</li> <li>Orientation and resolution: same as resting-state images</li> <li>Intended for EPI distortion correction</li> </ul> </li> </ul> <p><strong>Publications</strong></p> <ul> <li>Lv, Q., Yang, L., Li, G., Wang, Z., Shen, Z., Yu, W., Jiang, Q., Hou, B., Pu, J., Hu, H., &amp; Wang, Z. (2016). Large-Scale Persistent Network Reconfiguration Induced by Ketamine in Anesthetized Monkeys: Relevance to Mood Disorders. Biological Psychiatry, 79(9), 765&ndash;775. <a href="https://doi.org/10.1016/j.biopsych.2015.02.028">https://doi.org/10.1016/j.biopsych.2015.02.028</a></li> </ul> <p><strong>Personnel</strong></p> <p>Zheng Wang<sup>1</sup></p> <p><sup>1</sup>Institute of Neuroscience, Key Laboratory of Primate Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China</p> <p><strong>Acknowledgements</strong></p> <p>The authors thank Drs. Lawrence Wald, Ravi Menon, John Gore, Franz Schmitt, Renate Jerecic, Thomas Benner, Kecheng Liu, Ignacio Vallines, and Hui Liu for their generous help and contribution to the construction of our custom-tuned gradient-insert (AC88) 3T MRI facility for nonhuman primate subjects.</p> <p><strong>Funding</strong></p> <ul> <li>Hundred Talent Program of Chinese Academy of Sciences (Technology) (Zheng Wang)</li> <li>Chinese 973 Program (2011CBA00400)</li> <li>The &ldquo;Strategic Priority Research Program (B) of the Chinese Academy of Sciences (XDB02030004)</li> <li>The Outstanding Youth Grant (Hailan Hu)</li> </ul> <p>Detailed information can be found at&nbsp;<a href="http://fcon_1000.projects.nitrc.org/indi/PRIME/ion.html">http://fcon_1000.projects.nitrc.org/indi/PRIME/ion.html</a>.</p> <p><strong>Citation</strong>&nbsp;</p> <ul> <li>Wang, Z. (2019). Macaca mulatta and Macaca fascicularis anatomical and functional MRI data [Data set]. Zenodo. <a href="https://doi.org/10.5281/ZENODO.3402112">https://doi.org/10.5281/ZENODO.3402112</a>.</li> <li>Milham, M. P., Ai, L., Koo, B., Xu, T., Amiez, C., Balezeau, F., &hellip; Schroeder, C. E. (2018). An Open Resource for Non-human Primate Imaging. Neuron, 100(1), 61&ndash;74.e2. <a href="https://doi.org/10.1016/j.neuron.2018.08.039">https://doi.org/10.1016/j.neuron.2018.08.039</a>.</li> </ul>

opencc-by-nc-sa-4.0Dec 2018View details →
ClinicalTrials.gov40/100

Investigation of Brain Functional MRI as an Early Biomarker of Recovery in Individuals With Spinal Cord Injury

ClinicalTrials.gov study NCT03854214. IPD Sharing: YES. Countries: 1. Publications: 4.

controlledIPD-YESFeb 2026View details →
dryad36/100

Data from: Changes in brain structure and function following exposure to oral LSD during adolescence: A multimodal MRI study

<p><em>Background</em>: LSD  is a hallucinogen with complex neurobiological and behavioral effects.  Underlying these effects are changes in brain neuroplasticity. This is the first study to follow the developmental changes in brain structure and function following LSD exposure in periadolescence.  We hypothesized LSD given during a time of heightened neuroplasticity, particularly in the forebrain, would affect cognitive and emotional behavior and the associated underlying neuroanatomy and neurocircuitry.   </p> <p><em>Methods:</em> Female and male mice were given vehicle, single, or multiple treatments of 3.3 µg of LSD by oral gavage starting on postnatal day 51. Between postnatal days 90-120 mice were imaged and tested for cognitive and motor behavior. MRI data from voxel-based morphometry, diffusion weighted imaging, and BOLD resting state functional connectivity were registered to a mouse 3D MRI atlas with 139 brain regions providing site-specific differences in global brain structure and functional connectivity between experimental groups.</p> <p><em>Results:</em> Motor behavior and cognitive performance were unaffected by periadolescent exposure to LSD. Differences across experimental groups in brain volume for any of the 139 brain areas were few in number and not focused on any specific brain region. Multiple exposures to LSD significantly altered gray matter microarchitecture across much of the brain. These changes were primary associated with the thalamus, sensory and motor cortices, and basal ganglia. The forebrain olfactory system and prefrontal cortex and hindbrain cerebellum and brainstem were unaffected. The functional connectivity between forebrain white matter tracts and sensorimotor cortices and hippocampus was reduced with multidose LSD exposure.</p> <p><em>Conclusion:</em> Does early exposure to LSD in periadolescence have lasting effects on brain development? There was no evidence of LSD having consequential effects on cognitive or motor behavior when animal were evaluated as young adults 90-120 days of age.   Neither were there any differences in the volume of specific brain areas between experimental conditions. The pronounced changes in indices of anisotropy across much of the brain would suggest altered gray matter microarchitecture and neuroplasticity. The reduction in connectivity in forebrain white matter tracts with multidose LSD and consolidation around sensorimotor and hippocampal brain areas requires a battery of tests to understand the consequences of these changes on behavior.</p>

opencc-zeroJul 2024View details →
dryad36/100

Data from: Structural and functional brain connectome in motor neuron diseases: a multicenter MRI study

Objective. To investigate structural and functional neural organization in amyotrophic lateral sclerosis (ALS), primary lateral sclerosis (PLS) and progressive muscular atrophy (PMA) patients. Methods. 173 ALS, 38 PLS, 28 PMA sporadic patients and 79 healthy controls were recruited from three Italian centers. Subjects underwent clinical, neuropsychological and brain MRI evaluations. Using graph analysis and connectomics, global and lobar topological network properties and regional structural and functional brain connectivity were assessed. The association between structural and functional network organization and clinical/cognitive data was investigated. Results. Compared to healthy controls, ALS and PLS patients showed altered structural global network properties, as well as local topological alterations and decreased structural connectivity in sensorimotor, basal ganglia, frontal and parietal areas. PMA patients showed preserved global structure. Patient groups did not show significant alterations of functional network topological properties relative to controls. Increased local functional connectivity was observed in ALS patients in the precentral, middle and superior frontal areas, and in PLS patients in the sensorimotor, basal ganglia and temporal networks. In both ALS and PLS patients, structural connectivity alterations correlated with motor impairment, while functional connectivity disruption was closely related to executive dysfunctions and behavioral disturbances. Conclusions. This multicenter study showed widespread motor/extra-motor network degeneration in ALS and PLS, suggesting that graph analysis and connectomics might represent a powerful approach to detect upper motor neuron degeneration, extra-motor brain changes and network reorganization associated with the disease. Network-based advanced MRI provides an objective in vivo assessment of motor neuron diseases, delivering potential prognostic markers.

opencc-zeroJul 2021View details →
ClinicalTrials.gov36/100

A Study to Evaluate the Effects of Milnacipran on Pain Processing and Functional MRI in Patients With Fibromyalgia

ClinicalTrials.gov study NCT01173055. IPD Sharing: Not stated. Countries: 1. Publications: 1.

restrictedIPD-UNDECIDEDFeb 2026View details →
ClinicalTrials.gov36/100

Evaluate Cardiac Function Using Cardiac MRI and Dosimetric Correlation

ClinicalTrials.gov study NCT02348684. IPD Sharing: YES. Countries: 1. Publications: 1.

controlledIPD-YESFeb 2026View details →
dryad36/100

Data from: Changes in brain structure and function following exposure to oral LSD during adolescence: A multimodal MRI study

Open the record for dataset details and reuse information.

publicJul 2024View details →
dryad36/100

Data from: Structural and functional brain connectome in motor neuron diseases: a multicenter MRI study

Open the record for dataset details and reuse information.

publicJul 2021View details →
ClinicalTrials.gov32/100

Functional MRI of Hypoxia-mediated Rectal Cancer Aggressiveness

ClinicalTrials.gov study NCT01816607. IPD Sharing: Not stated. Countries: 1. Publications: 7.

restrictedIPD-UNDECIDEDFeb 2026View details →
ClinicalTrials.gov32/100

Evaluation of Remnant Liver Function Using Primovist-enhanced MRI Before Resection/Ablation of Hepatocellular Carcinoma

ClinicalTrials.gov study NCT01490203. IPD Sharing: NO. Countries: 1. Publications: 1.

closedIPD-NOFeb 2026View details →
ClinicalTrials.gov32/100

Functional MRI Changes Resulting From the Feuerstein Program in Older People With Mild Cognitive Impairment (MCI)

ClinicalTrials.gov study NCT03447236. IPD Sharing: NO. Countries: 1. Publications: 12.

closedIPD-NOFeb 2026View details →

ScienceDex guides

Understand access before you commit

These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.

Compare curated datasets

Allen Brain Atlas

Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.

allen-brain-atlas
neuroscienceopenDocumentation, web resources, and API references are available online.
Last verified 2026-04-30Open record

Annotated Behaviour and Observability Dataset (ABODe)

ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.

abode-home-cage
behavioral-neuroscienceopenThe DataShare record exposes download links for annotations, documentation, license text, and the zipped per-snippet data directory.
Last verified 2026-04-30Open record

DANDI Archive for NWB datasets

DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.

dandi-nwb
electrophysiologyopenPublished Dandiset metadata and archive endpoints are available through the production DANDI API.
Last verified 2026-04-30Open record

International Brain Laboratory public data

The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.

ibl
behavioral-neuroscienceopenPublic sessions can be searched and loaded from the IBL public data server through ONE.
Last verified 2026-04-29Open record

OpenNeuro

OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.

openneuro
neuroscienceopenPublished datasets are available on demand over the internet.
Last verified 2026-04-29Open record