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35 results for “Functional gastrointestinal disorder”
Raw Data for the article: Functional Gastrointestinal Disorders in Patients With Epilepsy: Reciprocal Influence and Impact on Seizure Occurrence
<p><strong>Introduction:</strong> The complex relationship between the microbiota-gut-brain axis (MGBA) and epilepsy has been increasingly investigated in preclinical studies. Conversely, evidence from clinical studies is still scarce. In recent years, the pivotal role of MGBA dysregulation in the pathophysiology of functional gastrointestinal disorders (FGID) has been recognized. With this background, we aimed to investigate the prevalence of FGID in patients with epilepsy (PWE) and the possible impact of bowel movement abnormalities on seizure recurrence. <strong>Methods:</strong> A total of 120 PWE and 113 age-, sex-, and BMI-matched healthy subjects (HS) were consecutively enrolled. A questionnaire to evaluate the presence of FGID (according to Rome III diagnostic criteria) was administrated to all participants. In a subgroup of drug-resistant patients, we administered an <em>ad-hoc</em> questionnaire combining Bristol stool charts and seizure diaries to evaluate seizure trends and bowel movement changes. <strong>Results:</strong> A higher prevalence of FGID in PWE (62.5%) than in HS (39.8%) was found (<em>p</em> < 0.001). The most frequently observed disorder was constipation, which was significantly higher in PWE than in HS (43.3 vs. 21.2%, <em>p</em> < 0.001), and was not associated with anti-seizure medication intake according to multivariable analysis. In drug-resistant patients, most seizures occurred during periods of altered bowel movements, especially constipation. A significant weak negative correlation between the number of days with seizures and the number of days with normal bowel movements was observed (<em>p</em> = 0.04). According to multivariable logistic regression analysis, FGID was significantly associated with temporal lobe epilepsy as compared with other lobar localization (<em>p</em> = 0.03). <strong>Conclusions:</strong> Our clinical findings shed new light on the complex relationship between epilepsy and the MGBA, suggesting a bidirectional link between bowel movement abnormalities and seizure occurrence. However, larger studies are required to better address this important topic.</p>
A Study of Randomized Sham-control Auricular TENS Unit Stimulation in Pediatric Functional Gastrointestinal Disorders
ClinicalTrials.gov study NCT04247100. IPD Sharing: NO. Countries: 1. Publications: 3.
Evolution of Functional Gastrointestinal Disorders in Infants Fed With a New Infant Formula
ClinicalTrials.gov study NCT06488274. IPD Sharing: NO. Countries: 1. Publications: 4.
i-CBT Functional Gastrointestinal Disorders in Youth: the Impact of Negative Illness Understanding and Parental Illness Worries
ClinicalTrials.gov study NCT05486585. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Heart Rate Variability (HRV) Biofeedback Training in Functional Gastrointestinal Disorders (FGID)
ClinicalTrials.gov study NCT06687057. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Bifidobacteria In Children With Abdominal Pain-Associated Functional Gastrointestinal Disorders
ClinicalTrials.gov study NCT02566876. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Fructose and Lactose Intolerance and Malabsorption in Functional Gastrointestinal Disorders
ClinicalTrials.gov study NCT02085889. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Efficacy of Linaclotide in Patients With Overlapping Functional Gastrointestinal Disorders
ClinicalTrials.gov study NCT05134584. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Prevalence and Natural History of Functional Gastrointestinal Disorders Among At-risk Infants.
ClinicalTrials.gov study NCT06031025. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Butyrate Supplementation in Children With Autism Spectrum Disorder (ASD) and Functional Gastrointestinal Disorders
ClinicalTrials.gov study NCT06514573. IPD Sharing: NO. Countries: 1. Publications: 18.
Glucomannan for the Treatment of Abdominal Pain-related Functional Gastrointestinal Disorders in Childhood
ClinicalTrials.gov study NCT01495806. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Internet-delivered CBT for Functional Gastrointestinal Disorders (FGID) in Youth: a Single Case Experimental Design
ClinicalTrials.gov study NCT05237882. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Frequency of Functional Gastrointestinal Disorders in Children
ClinicalTrials.gov study NCT04320550. IPD Sharing: UNDECIDED. Countries: 0. Publications: 2.
Multi-center Study on Pediatric Functional Gastrointestinal Disorders in Mainland China
ClinicalTrials.gov study NCT04388137. IPD Sharing: NO. Countries: 0. Publications: 4.
Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders
GEO Series GSE128189. Homo sapiens. 32 samples. Type: Expression profiling by high throughput sequencing.
Effect of 35624® Alflorex® in Functional Gastrointestinal Disorders (FGIDs) in Children.
ClinicalTrials.gov study NCT04922476. IPD Sharing: NO. Countries: 1. Publications: 0.
Cow's Milk Allergy and Functional Gastrointestinal Disorders
ClinicalTrials.gov study NCT01901380. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Efficacy of Audio Recorded Guided Imagery vs Deep Breathing Exercises on Functional Gastrointestinal Pain Disorders
ClinicalTrials.gov study NCT03100487. IPD Sharing: NO. Countries: 1. Publications: 0.
Long Term Follow up on Functional Gastrointestinal Disorder (FGID)
ClinicalTrials.gov study NCT02689648. IPD Sharing: NO. Countries: 1. Publications: 0.
Effect of Fecal Microbiota Transplantation (FMT) in Pediatric Functional Gastrointestinal Disorders
ClinicalTrials.gov study NCT05753774. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.