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128 results for “GABA”
Visual-Evoked Potential (VEP) Event-Related Files from the General Anesthesia and Brain Activity (GABA) Study and Infant Sibling Project (ISP)
<p>HAPPE+ER software was optimized for developmental data using a subset of EEG files from 4-month and 10-month old infants in the General Anesthesia and Brain Activity (GABA) Study. While medically necessary, 1-2 million infants each year undergo general anesthesia – a process that sedates brain activity and impacts early sensory experiences during a time typically characterized by rapid neurocognitive development. The GABA study examines sensory and socioemotional neurodevelopment longitudinally from infancy through childhood in individuals who have and who have never undergone general anesthesia during different windows in the first year of life. The GABA study was carried out in accordance with the recommendations of the Institutional Review Board at Boston Children’s Hospital. All caregivers provided assent for their child’s participation in the GABA study and for the release of the deidentified data. </p> <p>To facilitate the use and understanding of HAPPE+ER software, we have provided a subset of the validation files from the GABA study to serve as a tutorial dataset for how to run event-related potential (ERP) data through this automated processing pipeline. Five files (a.raw - e.raw) are from four 4-month and one 10-month old infants during a pattern reversal visual-evoked potential (VEP) paradigm. Pattern reversal occurred every 500 milliseconds. The pattern stimulus onset is indicated in each file by the code: vep+. Data was collected using a 128-channel EGI HydroCel Geodesic Sensor Net and EGI Net Amps 400, sampled at 1000Hz with an online reference to channel CZ. </p> <p>We have also included a subset of files from the Infant Sibling Project (ISP), an investigation examining infants at high versus low familial risk for autism spectrum disorder over the first 3 years of life. Baseline EEG data was collected while a young child sat in a parent’s lap watching a research assistant blow bubbles or show toys for several minutes. The Infant Sibling Project was carried out in accordance with the recommendations of the Institutional Review Board at Boston University and Boston Children’s Hospital (#X06-08-0374), with written informed consent from all caregivers prior to their child’s participation in the study. All files here have been deidentified, including alteration of exact acquisition dates. Acquisition times have not been altered. For additional information about data collection paradigms, and sample studies published on the larger ISP data set, please see the following references:</p> <ol> <li>Levin, A. R., Varcin, K. J., O’Leary, H. M., Tager-Flusberg, H., and Nelson, C. A. (2017). EEG power at 3 months in infants at high familial risk for autism. J. Neurodev. Disord. 9, 1–13.</li> <li>Gabard-Durnam, L.J., Wilkinson, C., Kapur, K. et al. Longitudinal EEG power in the first postnatal year differentiates autism outcomes. Nat Commun 10, 4188 (2019). <a href="https://doi.org/10.1038/s41467-019-12202-9">https://doi.org/10.1038/s41467-019-12202-9</a></li> </ol> <p>Here we provide a subset of the full dataset with a simulated VEP signal added into the data, as example files for HAPPE+ER. To create these files, we selected a subset of 39 spatially-distributed channels in the baseline EEG files and created sixteen 30-second files using continuous segments of relatively artifact-free (clean) baseline data from the full-length files. Next, from 30-second sections of the same individuals’ EEG that were artifact-laden, we ran ICA and extracted artifact independent components (identified by an expert and labeled artifact by both ICLabel and MARA automated algorithms). We inserted the artifact ICs into that individual’s clean 30-second data segment to create an additional 16 artifact-added files. We then selected a channel from a simulated VEP dataset (included here as simulated_full.set) with a stereotyped and prominent simulated VEP waveform, in this case Oz, and added its timeseries (included here as simulated_singleChan.set) to each channel of the clean and artifact-added files to create two VEP datasets with a known ERP morphology (sim-artifact_a-p and sim-clean_a-p). For additional information about the creation of this simulated data and VEP data with a known ERP morphology, please refer to Monachino et al., in revision; DOI: https://doi.org/10.1101/2021.07.02.450946.</p> <p>Additional files included below are the HAPPE+ER data and pipeline quality metric output spreadsheets for the five GABA study data files for an example run, the output spreadsheet containing the ERP timeseries from the generateERPs script, the .mat file containing the parameter settings for HAPPE+ER for that run, an Excel file with the bad channels for each file, and a tutorial document illustrating the results of this example run. </p>
Stimulation of medial amygdala GABA neurons with kinetically different channelrhodopsins yields opposite behavioral outcomes
<p>This dataset continues the dataset accessible by doi 10.5281/zenodo.4311847. The latter also contains all the relevant metadata description.</p>
Stimulation of medial amygdala GABA neurons with kinetically different channelrhodopsins yields opposite behavioral outcomes
<p>This dataset represents the raw data that gave rise to the study by Baleisyte et al., Cell Reports 2022 (DOI: 10.1016/j.celrep.2022.110850), previously published as a preprint at bioRxiv (DOI: 10.1101/2021.06.30.450543). Please refer to the original publication regarding experimental design and methodological details of data acquisition and analysis. Below we supply information on the provided metadata files which, in turn, refer to individual raw data files.</p> <p><strong>General repository structure:</strong></p> <ul> <li>the raw data is organized in 11 datasets related to the Figures 1, S1, 2, S2, 3A-H, 3I-K, 3L-N, S3A-I, S3J-P, 4A;C-G;H_top;I-J;S4, 4B;C-G;H_bottom;I-J;S4;</li> <li>the metadata listing individual data filenames from the individual dataset are stored in separate “.csv” files, one per dataset. Field separator: comma;</li> <li>the custom script for the reconstruction of the optic fiber placement is described in a separate metadata file “script_metadata.csv”. Field separator: comma;</li> <li>all individual metadata files are summarized in a master metadata file “metadata_master.csv”. Field separator: comma.</li> <li>the data files related to Figures 2, S2, S3A-I are continued in a separate linked repository accessible by the following doi: 10.5281/zenodo.6489354</li> </ul> <p> </p> <p><strong>Description of the data formats:</strong></p> <ul> <li>video recordings of resident-intruder test experiments (Figures 1, 3, S1) are provided as unmodified “.mpg” files created by the acquisition software EthoVision (Noldus Information Technology). The files were, however, renamed for convenience. Video stream parameters: MPEG-4 (DIVX) codec, color space yuv420p, 1280x512 pixels, 30 fps. Along with each video file, there is an associated text file (“.txt”) containing the metadata of video recording and the timestamps of hardware state changes. In these files, unmodified after creation by the EthoVision software, the status of hardware TTL inputs was logged whenever a change of state of these inputs was detected. Typically, “input 2” was sampling the gating signal from the Master-8 pulse generator, with the "high" signal level indicating the application of train of light pulses. This hardware state, signaling the presence of the light train, is noted in the individual metadata files; </li> <li>widefield fluorescent images of single coronal sections containing the MeApd (Figures 2, S2) were converted from the proprietary format of Olympus slide scanning microscope into composite TIFF format, readable by FIJI/ImageJ (<a href="https://fiji.sc/">https://fiji.sc/</a> or <a href="https://imagej.net/Fiji/Downloads">https://imagej.net/Fiji/Downloads</a>). The information on pixel resolution and inter-section distance is embedded in the individual image files as TIFF metadata. Attribution of fluorescent probes to the color channels is given in the corresponding metadata files.</li> <li>confocal fluorescent image stacks acquired from single coronal sections containing MeApd (Figure S3) are provided in composite TIFF format after stitching the tiles (originally stored as “lsm” format; Carl Zeiss) using a stitching plugin (Preibisch et al., Bioinformatics 2009) in FIJI. The information on pixel resolution is embedded inside the individual image files as TIFF metadata. Attribution of fluorescent probes to the color channels is given in the corresponding metadata file. For each stack, a region of interest (ROI) highlighting the borders of the MeApd is provided as a separate file in a “.roi“ format (FIJI).</li> <li>patch clamp recordings (Figures 4, S4) are provided as “.dat” files, unmodified from the original version created by the acquisition software PatchMaster (HEKA Elektronik, Germany). Besides by the original PatchMaster software, these files can be imported using one of the following methods: I) via Igor Pro extension bpc_ReadHeka.xop (for 32-bit Igor Pro versions 5.xx - 6.37) by Holger Taschenberger (<a href="https://www.wavemetrics.com/project/bpc_ReadHeka">https://www.wavemetrics.com/project/bpc_ReadHeka</a>); II) via Python script by Luke Campagnola (<a href="https://github.com/campagnola/heka_reader">https://github.com/campagnola/heka_reader</a>); III) via Matlab script HEKA PatchMaster Importer by Christian Keine (<a href="https://github.com/ChristianKeine/HEKA_Patchmaster_Importer">https://github.com/ChristianKeine/HEKA_Patchmaster_Importer</a>).</li> </ul>
What Can MR Spectroscopy Measures of Occipital GABA tellabout Visual Plasticity in Human Adult?: Exp3 Dataset
<p>Dataset from Exp3 in "Proulx, Sébastien, Sheynin, Yasha, Hess, Robert, & Farivar, Reza. (2020). What Can MR Spectroscopy Measures of Occipital GABA tell about Visual Plasticity in Human Adult?. Zenodo. http://doi.org/10.5281/zenodo.4034898".</p> <p>Data was collected in 3-min measures: 3 pre-deprivation seperated by 3-min breaks and 3 deprivation measured at 30, 50 and 70 minutes into deprivation.</p> <p>The 'data' variable from the exp3Data.mat file stores percept durations that were logged then averaged within measures.</p> <p>The 'dataTot' variable from the exp3Data.mat file is the same data as in the 'data' variable, but processed differently as the fraction of a measure time (180min) a given percept is perceived.</p> <p>Metadata is included in the data and dataTot variable structure.</p>
Fitness costs associated with a GABA receptor mutation conferring dieldrin resistance in Aedes albopictus
<p><span>Understanding the dynamics of insecticide resistance genes in mosquito populations is pivotal for a sustainable use of insecticides. Dieldrin resistance in <em>Aedes</em> <em>albopictus</em> is conferred by the alanine to serine substitution (A302S or <em>Rdl<sup>R</sup></em> allele) in the γ-aminobutyric acid (GABA) receptor encoded by the <em>Rdl</em> gene. On Reunion Island, dieldrin resistance was initially reported in natural <em>Ae</em>. <em>albopictus</em> populations sampled in 2008 despite the ban of dieldrin since 1994. To monitor insecticide resistance in <em>Ae</em>. <em>albopictus</em> on the island and to identify its drivers, we measured (i) the frequency of resistance alleles in 19 distinct natural populations collected between 2016 and 2017, (ii) fitness costs associated with dieldrin resistance in laboratory-controlled experiments, and (iii) the resistance conferred by </span><span><em>Rdl<sup>R</sup></em></span><span> to fipronil, an insecticide widely used on the island and reported to cross-react with </span><span><em>Rdl<sup>R</sup></em></span><span>. The results show a persistence of </span><span><em>Rdl<sup>R</sup></em></span><span> in <em>Ae</em>. <em>albopictus</em> natural populations at low frequencies. Among the measured life history traits, mortality in pre-imaginal stages, adults' survival as well as the proportion of egg-laying females were significantly affected in resistant mosquitoes. Finally, bioassays revealed resistance of </span><span><em>Rdl<sup>R</sup></em></span><span> mosquitoes to fipronil, suggesting that the use of fipronil <em>in</em> <em>natura</em> could select for the </span><span><em>Rdl<sup>R</sup></em></span><span> allele. This study shows that dieldrin resistance is persistent in natural mosquito populations likely as a result of combined effects between fitness costs associated with </span><span><em>Rdl<sup>R</sup></em></span><span> and selection exerted by cross-reacting environmental insecticides such as fipronil.</span></p>
DSC for pemetrexed, PEG, GABA, physical mixture of pemetrexed with PEG, physical mixture of pemetrexed with GABA, pemetrexed-PEG conjugate, and pemetrexed-GABA conjugate
<p>This data represent the figures of DSC for pemetrexed, PEG, GABA, physical mixture of pemetrexed with PEG, physical mixture of pemetrexed with GABA, pemetrexed-PEG conjugate, and pemetrexed-GABA conjugate</p>
GABA Mechanisms Underlying the Vulnerability to Alcohol Dependence
ClinicalTrials.gov study NCT00611767. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Gamma-Amino Butyric Acid (GABA)-A Alpha2/3 Study
ClinicalTrials.gov study NCT00129441. IPD Sharing: Not stated. Countries: 1. Publications: 3.
iGABASnFR data from: Co-release of GABA and ACh from medial olivocochlear neurons as a fine regulatory mechanism of cochlear efferent inhibition
Open the record for dataset details and reuse information.
Fitness costs associated with a GABA receptor mutation conferring dieldrin resistance in Aedes albopictus
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An endogenous GLP-1 circuit engages VTA GABA neurons to regulate mesolimbic dopamine neurons and attenuate cocaine seeking
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Plasticity of GABA Inhibition in the Early Visual Cortex of Human Adults: Exp1 dataset
<p>Dataset from Exp1 in "Proulx, Sébastien, Sheynin, Yasha, Hess, Robert, & Farivar, Reza. (2020). Plasticity of GABA Inhibition in the Early Visual Cortex of Human Adults (in preparation).</p> <p>Metadata included in the 'data' variable of the exp1Data.mat file.</p>
Source data for: Presynaptic NMDARs cooperate with local spikes toward GABA release from the reciprocal olfactory bulb granule cell spine
<p><span>In the rodent olfactory bulb the smooth dendrites of the principal glutamatergic mitral cells (MCs) form reciprocal dendrodendritic synapses with large spines on GABAergic granule cells (GC), where unitary release of glutamate can trigger postsynaptic local activation of voltage-gated Na<sup>+</sup>-channels (Na<sub>v</sub>s), i.e. a spine spike. Can such single MC input evoke reciprocal release? We find that unitary-like activation via two-photon uncaging of glutamate causes GC spines to release GABA both synchronously and asynchronously onto MC dendrites. This release indeed requires activation of Na<sub>v</sub>s and high-voltage-activated Ca<sup>2+</sup>-channels (HVACCs), but also of NMDA receptors (NMDAR). Simulations show temporally overlapping HVACC- and NMDAR-mediated Ca<sup>2+</sup>-currents during the spine spike, and ultrastructural data prove NMDAR presence within the GABAergic presynapse. The cooperative action of presynaptic NMDARs allows to implement synapse-specific, activity-dependent lateral inhibition and thus could provide an efficient solution to combinatorial percept synthesis in a sensory system with many receptor channels. </span></p>
Plasticity of GABA Inhibition in the Early Visual Cortex of Human Adults: Exp2 dataset
<p>Dataset from Exp2 in "Proulx, Sébastien, Sheynin, Yasha, Hess, Robert, & Farivar, Reza. (2020). Plasticity of GABA Inhibition in the Early Visual Cortex of Human Adults (in preparation).</p> <p>Data was collected in 3-min measures: 2 consecutive pre-deprivation and 2 consecutive immediate post-deprivation.</p> <p>The 'data' variable from the exp3Data.mat file stores percept durations that were logged then averaged within measures.</p> <p>Metadata is included in the data and dataTot variable structure.</p>
The effects of dietary proline, β-alanine, and γ-aminobutyric acid (GABA) on the nest construction behavior in the Oriental hornet
<p>Dataset for "The effects of dietary proline, β-alanine, and γ-aminobutyric acid (GABA) on the nest construction behavior in the Oriental hornet "</p>
Data and Images for Tonic dendritic GABA release by substantia nigra dopaminergic neurons
<p>Figure1_data.xlsx</p> <p>Numerical data for the charts in Figure 1C and Figure 1E</p> <p><br>Figure1A_GP.tif</p> <p>Fluorescent image (red channel, Chronos) for Figure 1A. </p> <p><br>Figure2_data.xlsx</p> <p>Numerical data for the charts in Figure 2B and Figure 2C</p> <p><br>Figure3_data.xlsx</p> <p>Numerical data for the charts in Figure 3A, 3B, and 3C.</p> <p><br>Figure4_data.xlsx</p> <p>Numerical data for the charts in Figure 4A and 4B.</p> <p><br>Figure5_data.xlsx</p> <p>Numerical data for the charts in Figure 5B and 5C.</p> <p><br>Figure6_data.xlsx</p> <p>Numerical data for the charts in Figure 6D, 6E, 6F, 6G and 6H.</p> <p> </p> <p>Figure6A_ALDH_Positive.tif</p> <p>DAT-Cre positive, ALDH1A1 positive axons of SNc neurons in Rostral SNr. </p> <p><br>Figure6A_ALDH_Negative.tif</p> <p>DAT-Cre positive, ALDH1A1 negative axons of SNc neurons in Rostral SNr.</p> <p><br>Figure6B_ALDH_Positive.tif</p> <p>DAT-Cre positive, ALDH1A1 positive axons of SNc neurons in Caudal SNr. </p> <p><br>Figure6B_ALDH_Negative.tif</p> <p>DAT-Cre positive, ALDH1A1 negative axons of SNc neurons in Caudal SNr.</p> <p><br>Figure6C_shRNA.tif</p> <p>Fluorescent image (red channel: ALDH_shRNA) for Figure 6C.</p> <p><br>Figure7_data.xlsx</p> <p>Numerical data for the charts in Figure 7D and 7E.</p> <p><br>Figure7A_10x.tif</p> <p>Confocal image (red channel: PSAM_FusionRed; green channel: anti-TH) for Figure 7A.</p> <p><br>Figure7B_60x.tif</p> <p>Confocal image (red channel: PSAM_FusionRed; green channel: anti-TH) for Figure 7B. </p> <p><br>Figure8_data.xlsx</p> <p>Numerical data for the charts in Figure 8A and 8B. </p> <p> </p> <p>Figure_S1_data.xlsx</p> <p>Numerical data for the chart in Figure S1</p> <p><br>Figure_S2_data.xlsx</p> <p>Numerical data for charts in Figure S2 C - E</p>
What's GABA got to do with it? A potential link between the microbiome, schizophrenia, and the endocannabinoid system
<p><span>This study is unique in that it explores specific microbial and metabolic alterations in patients grouped by medications. Further, this study reveals interesting metabolic trends that may be valuable towards unearthing a pathophysiological mechanism for schizophrenia, which is currently lacking. </span></p>
Cortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls
<p>This link contains the Data Source files, the code, and raw MRS data analysed in <a href="https://www.researchsquare.com/article/rs-2152573/v1">this article</a>. </p>
FTIR Figures for pemetrexed, PEG, GABA, physical mixture of pemetrexed with PEG, physical mixture of pemetrexed with GABA, pemetrexed-PEG conjugate, and pemetrexed-GABA conjugate
<p>This file represent FTIR Figures for pemetrexed, PEG, GABA, physical mixture of pemetrexed with PEG, physical mixture of pemetrexed with GABA, pemetrexed-PEG conjugate, and pemetrexed-GABA conjugate</p>
LC-MS results for unconjugated antibody (Atezolizumab (AtZ)) , pemetrexed-PEG-Atezolizumab (PemPEG-AtZ conjugate), and pemetrexed-GABA-Atezolizumab (PemGABA-AtZ conjugate)
<p>This data represent the figures of LC-MS results for unconjugated antibody (Atezolizumab (AtZ)) , pemetrexed-PEG-Atezolizumab (PemPEG-AtZ conjugate), and pemetrexed-GABA-Atezolizumab (PemGABA-AtZ conjugate)</p>
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.