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ShareScore release 0.9.0
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11 results for “GAS5”
GAS5 protects against osteoporosis by targeting UPF1/SMAD7 axis in osteoblast differentiation
<p>Osteoporosis is a common systemic skeletal disorder resulting in bone fragility and increased fracture risk. It is still necessary to explore its detailed mechanisms and identify novel targets for the treatment of osteoporosis. Previously, we found that an lncRNA named GAS5 in humans could negatively regulate lipoblast/adipocyte differentiation. However, it is still unclear whether GAS5 affects osteoblast differentiation and whether GAS5 is associated with osteoporosis. Our current research found that GAS5 was decreased in the bones and BMSCs, a major origin of osteoblast, in osteoporosis patients. Mechanistically, GAS5 promotes osteoblast differentiation by interacting with UPF1 to degrade Smad7 mRNA. Moreover, a decreased bone mass and impaired bone repair ability were observed in <em>Gas5</em> heterozygous mice, manifesting in osteoporosis. The systemic supplement of <em>Gas5</em>-overexpressing adenoviruses significantly ameliorated bone loss in an osteoporosis mouse model. In conclusion, GAS5 promotes osteoblast differentiation by targeting the UPF1/Smad7 axis and protects against osteoporosis.</p>
GAS5 protects against osteoporosis by targeting UPF1/SMAD7 axis in osteoblast differentiation
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The long non-coding RNA GAS5 differentially regulates cell cycle arrest and apoptosis in human neuroblastoma
GEO Series GSE90523. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Gas5 Pulldown Total and small RNAseq
GEO Series GSE180503. Mus musculus. 12 samples. Type: Other.
LncRNA-GAS5 negative regulation of YAP-target genes expression
GEO Series GSE129624. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Functional network of the long non-coding RNA growth arrest specific transcript 5 (GAS5) and its interacting proteins in senescence
GEO Series GSE163237. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
LncRNA GAS5 Regulates human Myometrial cells Contractions In a m6A-Dependent Manner
GEO Series GSE236038. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Role of long non-coding RNA Gas5 in cocaine action
GEO Series GSE146005. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
GAS5 controls Nodal autocrine in Human Embryonic Stem Cells Self-Renewal through competing endogenous mechanism
GEO Series GSE66993. Homo sapiens. 7 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
The SRSF4/lncRNA GAS5 axis regulates left ventricular hypertrophy by inhibiting the glucocorticoid receptor
GEO Series GSE131145. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
The effect of lncRNA GAS5 on lens epithelial cells
GEO Series GSE317222. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.