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152 results for “GATA2”
Data from: GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126
Mutations in the transcription factor GATA2 cause lymphedema. GATA2 is necessary for the development of lymphatic valves (LVs) and lymphovenous valves (LVVs), and for the patterning of lymphatic vessels. Here, we report that GATA2 is not necessary for valvular endothelial cell (VEC) differentiation. Instead, GATA2 is required for VEC maintenance and morphogenesis. GATA2 is also necessary for the expression of cell junction molecules VE-Cadherin and Claudin5 in lymphatic vessels. We identified miR-126 as a target of GATA2, and miR-126-/- embryos recapitulate the phenotypes of mice lacking GATA2. Primary human lymphatic endothelial cells (HLECs) lacking GATA2 (GATA2ΔHLEC) have altered expression of Claudin5 and VE-Cadherin, and blocking miR-126 activity in HLECs phenocopies these changes in expression. Importantly, overexpression of miR-126 in GATA2ΔHLEC significantly rescues the cell junction defects. Thus, our work defines a new mechanism of GATA2 and uncovers miR-126 as a novel regulator of mammalian lymphatic vascular development.
Allogeneic Hematopoietic Stem Cell Transplant for GATA2 Mutations
ClinicalTrials.gov study NCT01861106. IPD Sharing: YES. Countries: 1. Publications: 2.
Natural History Study of GATA2 Deficiency and Related Disorders
ClinicalTrials.gov study NCT01905826. IPD Sharing: YES. Countries: 1. Publications: 5.
Data from: GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126
Open the record for dataset details and reuse information.
Allogeneic Hematopoietic Stem Cell Transplantation With Briquilimab-Based Conditioning in Participants With GATA2 Deficiency
ClinicalTrials.gov study NCT05907746. IPD Sharing: YES. Countries: 1. Publications: 0.
Non-coding variants alter Gata2 expression in rhombomere 4 motor neurons and cause dominant hereditary congenital facial paresis
GEO Series GSE223274. Mus musculus. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development [zebrafish bulk RNA-seq2]
GEO Series GSE169689. Danio rerio. 5 samples. Type: Expression profiling by high throughput sequencing.
GATA2 tumor suppressive role revealed in ERG - AML mouse model, unveiling a preleukemic phenotype
GEO Series GSE143308. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Expression profiling of dendritic cell (DC) progenitors from Gata2 conditional knockout mice
GEO Series GSE82044. Mus musculus. 7 samples. Type: Expression profiling by array.
Overexpression of GATA2 enhances development and maintenance of human embryonic stem cell-derived hematopoietic stem cell-like progenitors
GEO Series GSE122207. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
FSH-deficiency in gonadotrope-specific GATA2 knockout mice is associated with a loss of gremlin expression
GEO Series GSE190066. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Functional and molecular characterization of mouse Gata2-independent hematopoietic progenitors
GEO Series GSE76254. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Multiclonal competition reveals impaired cell fitness of GATA2 deficient cells [RNA-seq]
GEO Series GSE282250. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
GATA2 promotes hematopoietic development and represses cardiac differentiation of human mesoderm
GEO Series GSE118980. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
GATA2 restricts genomic actions of innate immune mediators on fetal hematopoietic progenitor cells
GEO Series GSE218445. Mus musculus. 32 samples. Type: Expression profiling by high throughput sequencing.
Gene expression change in Gata2 conditional knockout mice adult renal collecting duct
GEO Series GSE52448. Mus musculus. 2 samples. Type: Expression profiling by array.
Gene expression changes in embryonic PECAM-1+ cells from Gata2 +9.5 enhancer targeted mice
GEO Series GSE39300. Mus musculus. 8 samples. Type: Expression profiling by array.
Next Generation Sequencing of Wild Type and Gata2-/- LSCs
GEO Series GSE133245. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
GATA2 promotes hematopoietic development and represses cardiac differentiation of human mesoderm
GEO Series GSE133996. Homo sapiens. 480 samples. Type: Expression profiling by high throughput sequencing.
Single-cell RNA-seq reveals a distinct transcriptome signature of hematopoiesis in GATA2 deficiency
GEO Series GSE135194. Homo sapiens. 13 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.