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27
datasets available to search
ShareScore release 0.9.0
Dataset results
27 results for “GENERALIZED EPILEPSY”
Open-Label Study to Assess Lacosamide Safety as Add-on Therapy for Primary Generalized Tonic-Clonic Seizures in Subjects With Epilepsy
ClinicalTrials.gov study NCT01118949. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Double-blind, Placebo-controlled Study of Levetiracetam in Epilepsy Patients With Generalized Tonic-clonic Seizures (Except Partial Seizures Evolving to Secondarily Generalized Seizures)
ClinicalTrials.gov study NCT01228747. IPD Sharing: Not stated. Countries: 2. Publications: 1.
A Study to Investigate the Safety and Efficacy of Lacosamide Added to the Patients Current Therapy in Patients Aged 1 Month to Less Than 18 Years Old With Epilepsy Syndromes Associated With Generalize
ClinicalTrials.gov study NCT01969851. IPD Sharing: Not stated. Countries: 5. Publications: 1.
Open-Label Extension Study to Assess the Safety and Seizure Frequency Associated With Lacosamide for Primary Generalized Tonic-Clonic Seizures in Subjects With Epilepsy
ClinicalTrials.gov study NCT01118962. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Investigation of the Clinical Safety and Efficacy of Long-term Treatment With Fycompa Tablets in Adolescence Epilepsy Patients With Partial-onset Seizures (With or Without Secondary Generalized Seizur
ClinicalTrials.gov study NCT03059381. IPD Sharing: NO. Countries: 1. Publications: 1.
Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy
ClinicalTrials.gov study NCT03590197. IPD Sharing: UNDECIDED. Countries: 1. Publications: 32.
Investigation of the Clinical Safety and Efficacy of Long-term Treatment With Fycompa Tablets in Adult Epilepsy Patients With Partial-onset Seizures (With or Without Secondary Generalized Seizures) or
ClinicalTrials.gov study NCT03059329. IPD Sharing: NO. Countries: 1. Publications: 1.
A Pilot Study: Focused Ultrasound Thalamotomy for the Prevention of Secondary Generalization in Focal Onset Epilepsy
ClinicalTrials.gov study NCT03417297. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Generalized polyspike train: an EEG biomarker of drug-resistant idiopathic generalized epilepsy
Objective: To identify clinical and EEG biomarkers of drug resistance in adults with idiopathic generalized epilepsy. Methods: We conducted a case-control study consisting of a discovery cohort and a replication cohort independently assessed at two different centres. In each centre patients with idiopathic generalized epilepsy phenotype and generalized spike-wave discharges on EEG were classified as drug-resistant or drug-responsive. EEG changes were classified into pre-defined patterns and compared between the two groups in the discovery cohort. Factors associated with drug resistance in multivariable analysis were tested in the replication cohort. Results: The discovery cohort included 85 patients (29% drug-resistant and 71% drug-responsive). Their median age at assessment was 32 years and 50.6% were female. Multivariable analysis showed that having higher number of seizure types (3 vs. 1: odds ratio [OR]= 31.1, 95% confidence interval [CI] 4.5-214, p<0.001; 3 vs. 2: OR=14.6, 95% CI: 2.3-93.1, p=0.004) and generalized polyspike train (burst of generalized rhythmic spikes lasting less than 1 second) during sleep were associated with drug resistance (OR=10.8, 95% CI: 2.4-49.4, p=0.002). When these factors were tested in the replication cohort of 80 patients (27.5% drug-resistant and 72.5% drug-responsive; 71.3% female; median age 27.5 years), the proportion of patients with generalized polyspike train during sleep was also higher in the drug-resistant group (OR=4.0, 95% CI: 1.35-11.8, p=0.012). Conclusion: Generalized polyspike train during sleep may be an EEG biomarker for drug resistance in adults with idiopathic generalized epilepsy.
Long Term Follow up Treatment With Levetiracetam in Subjects of 4 Years and Older With Generalized Epilepsy
ClinicalTrials.gov study NCT00150748. IPD Sharing: Not stated. Countries: 0. Publications: 1.
A Study of the Efficacy and Safety of Topiramate as "Add on" Treatment in Epilepsy Patients With Primary Generalized Tonic-clonic Seizures
ClinicalTrials.gov study NCT00236704. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Periodic Limb Movement and Genetic Generalized Epilepsy
ClinicalTrials.gov study NCT03587506. IPD Sharing: UNDECIDED. Countries: 0. Publications: 15.
Study to Evaluate the Safety and Efficacy of Levetiracetam in Patients Suffering From Idiopathic Generalized Epilepsy With Primary Generalized Tonic-clonic Seizures
ClinicalTrials.gov study NCT00160550. IPD Sharing: Not stated. Countries: 0. Publications: 2.
A Study of the Efficacy and Safety of Topiramate in Epilepsy Patients With Primary Generalized Tonic-clonic Seizures
ClinicalTrials.gov study NCT00236418. IPD Sharing: Not stated. Countries: 0. Publications: 1.
An Open Label Study of L059 (Levetiracetam) in Japanese Epilepsy Subjects With Generalized Tonic-clonic Seizures
ClinicalTrials.gov study NCT01398956. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Generalized polyspike train: an EEG biomarker of drug-resistant idiopathic generalized epilepsy
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Data from: Community-informed connectomics of the thalamocortical system in generalized epilepsy
Open the record for dataset details and reuse information.
A Study Evaluating NPT 2042 Versus Placebo in Subjects Aged 16-75 Years With Genetic Generalized Epilepsy (GGE) and Absence Seizures
ClinicalTrials.gov study NCT06769659. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of Attentional Disorders in Patients Suffering From Idiopathic Generalized Epilepsy.
ClinicalTrials.gov study NCT05530109. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Clinical Features and Outcome of Wilson's Disease With Generalized Epilepsy in Chinese Patients
ClinicalTrials.gov study NCT04965571. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
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