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268 results for “GM-CSF”
Data from: IFN-γ-independent control of M. tuberculosis requires CD4 T cell-derived GM-CSF and activation of HIF-1α
<p><strong>RNA sequencing dataset from "Van Dis et al., IFN-γ-independent control of M. tuberculosis requires CD4 T cell-derived GM-CSF and activation of HIF-1α. 2022"</strong></p> <p>The prevailing model of protective immunity to tuberculosis is that CD4 T cells produce the cytokine IFN-γ to activate bactericidal mechanisms in infected macrophages. Although IFN-γ-independent CD4 T cell based control of <em>M. tuberculosis</em> infection has been demonstrated <em>in vivo</em> it is unclear whether CD4 T cells are capable of directly activating macrophages to control infection in the absence of IFN-γ. We developed a co-culture model using CD4 T cells isolated from the lungs of infected mice and <em>M. tuberculosis</em>-infected murine bone marrow-derived macrophages (BMDMs) to investigate mechanisms of CD4 dependent control of infection. This dataset represents RNA sequencing data from M. tuberculosis-infected wild-type and <em>Ifngr-/- </em>murine bone marrow-derived macrophages (BMDMs) after 24 hours of lung CD4 T cell co-culture.</p> <p>CD4 T cells induced differential regulation of 1825 genes in wild-type BMDMs and 1142 genes in <em>Ifngr-/-</em> BMDMs compared to untreated. Although wild-type and <em>Ifngr-/-</em> BMDMs infected with <em>M. tuberculosis</em> were transcriptionally very similar prior to activation, the transcriptome of these genotypes of macrophages diverged after CD4 T cell co-culture. This is likely due in part to the presence or absence of IFN-γ signaling as IFN-γ alone regulates the expression of >2500 genes during <em>M. tuberculosis</em> infection. Still, 769 genes were altered in an IFN-γ-independent manner, with >2-fold upregulation in both wild-type and <em>Ifngr-/- </em>BMDMs. We found no difference in macrophage polarization between untreated M. tuberculosis-infected wild-type and <em>Ifngr-/-</em> BMDMs, and no significant increase in the expression of genes associated with M2 macrophages after CD4 T cell co-culture in either genotype. However, there was significant upregulation of genes associated with M1 macrophages after CD4 T cell co-culture in both genotypes, with wild-type BMDMs slightly more polarized. Collectively, these results show comparable patterns of activation in wild-type and <em>Ifngr-/-</em> macrophage during CD4 T cell co-culture, indicating that CD4 T cells elicit significant polarizing, inflammatory and antimicrobial effects in <em>M. tuberculosis</em>-infected macrophages irrespective of IFN-γ signaling.</p>
Pembrolizumab and GM-CSF in Biliary Cancer
ClinicalTrials.gov study NCT02703714. IPD Sharing: NO. Countries: 1. Publications: 1.
Vaccine Therapy and GM-CSF in Treating Patients With Acute Myeloid Leukemia, Myelodysplastic Syndromes, Non-Small Cell Lung Cancer, or Mesothelioma
ClinicalTrials.gov study NCT00398138. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Folate Receptor Alpha Peptide Vaccine With GM-CSF Versus GM-CSF Alone in Patients With Platinum Sensitive Ovarian Cancer
ClinicalTrials.gov study NCT02978222. IPD Sharing: NO. Countries: 1. Publications: 1.
Immuno-Augmentation With GM-CSF of Pneumococcal Vaccine in Chronic Lymphocytic Leukemia Patients
ClinicalTrials.gov study NCT00323557. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Inhaled GM-CSF Therapy of Autoimmune PAP
ClinicalTrials.gov study NCT00901511. IPD Sharing: NO. Countries: 1. Publications: 5.
Phase II PAP Plus GM-CSF Versus GM-CSF Alone for Non-metastatic Prostate Cancer
ClinicalTrials.gov study NCT01341652. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Vaccination With Autologous Breast Cancer Cells Engineered to Secrete Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) in Metastatic Breast Cancer Patients
ClinicalTrials.gov study NCT00317603. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Randomized, Double-blind, Phase 3 Efficacy Trial of PROSTVAC-V/F +/- GM-CSF in Men With Asymptomatic or Minimally Symptomatic Metastatic Castrate-Resistant Prostate Cancer
ClinicalTrials.gov study NCT01322490. IPD Sharing: Not stated. Countries: 16. Publications: 1.
Rituximab, Alemtuzumab, and GM-CSF As First-Line Therapy in Treating Patients With Early-Stage Chronic Lymphocytic Leukemia
ClinicalTrials.gov study NCT00562328. IPD Sharing: Not stated. Countries: 1. Publications: 1.
BATS With in Combination With Low Dose IL-1 and GM-CSF for Advanced Pancreatic Cancer
ClinicalTrials.gov study NCT02620865. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Autologous Vaccination With Lethally Irradiated, Autologous Breast Cancer Cells Engineered to Secrete GM-CSF in Women With Operable Breast Cancer
ClinicalTrials.gov study NCT00880464. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Randomized Trial of GM-CSF in Patients With ALI/ARDS
ClinicalTrials.gov study NCT00201409. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Efficacy and Safety Study of Talimogene Laherparepvec Compared to Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) in Melanoma
ClinicalTrials.gov study NCT00769704. IPD Sharing: Not stated. Countries: 4. Publications: 3.
G-CSF Versus G-CSF Plus GM-CSF for Stem Cell Mobilization in NHL Patients
ClinicalTrials.gov study NCT00499343. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Phase II Study of Fludarabine and Mitoxantrone, Followed by GM-CSF(Granulocyte-macrophage Colony-stimulating Factor) and Rituximab
ClinicalTrials.gov study NCT00208975. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy Study of Granulocyte-macrophage Colony Stimulating Factor (GM-CSF) for Use in Human IVF
ClinicalTrials.gov study NCT00565747. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Treadmill Exercise and GM-CSF Study to Improving Functioning in Peripheral Artery Disease (PAD)
ClinicalTrials.gov study NCT01408901. IPD Sharing: NO. Countries: 1. Publications: 12.
GM-CSF for Maintenance of Prostate Cancer for Patients Responding to Taxotere
ClinicalTrials.gov study NCT00274287. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: IFN-γ-independent control of M. tuberculosis requires CD4 T cell-derived GM-CSF and activation of HIF-1α
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