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Dataset results
13 results for “GeneXpert”
Byanyima et al- Feasibility and sensitivity of saliva GeneXpert MTBRIF Ultra for tuberculosis diagnosis in Ugandan adults
<p>The objective of this prospective, observational study carried out at China-Uganda Friendship Hospital-Naguru in Kampala, Uganda, was to determine the performance of GeneXpert MTB/RIF Ultra (Xpert Ultra) molecular testing on saliva for active tuberculosis (TB) disease among consecutive adults undergoing TB diagnostic evaluation who were Xpert Ultra positive on sputum. We calculated sensitivity to determine TB diagnostic performance in comparison to a composite reference standard of Mycobacterium tuberculosis (Mtb) liquid and solid cultures on two spot sputum specimens. Xpert Ultra on a single saliva sample had a sensitivity of 90% (95% CI 81-95%) relative to the composite sputum culture-based reference standard, similar to the composite sensitivity of 87% (95% CI, 77-94%) fluorescence smear microscopy (FM) for acid-fast bacilli on two sputa. The sensitivity of salivary Xpert Ultra was 24% lower (95% CI for difference 2-48%, p=0.003) among persons living with HIV (71%, 95% CI 44-90%) than among persons living without HIV (95%, 95% CI 86-99%) and 46% higher (95% CI 14-77%, p<0.0001) among FM-positive (96%, 95% CI 87-99%) than among FM-negative patients (50%, 95% CI 19-81%) patients. Semi-quantitative Xpert Ultra grade was systematically higher in sputum than in a paired saliva sample from the same patient. In conclusion, molecular testing of saliva for active TB diagnosis was feasible and almost as sensitive as molecular testing of sputum in a high TB-burden setting.</p>
Evaluating Accuracy, Impact, and Operational Challenges of GeneXpert Use for TB Case Finding Among HIV-infected Persons
ClinicalTrials.gov study NCT02538952. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
GeneXpert Performance Evaluation for Linkage to Tuberculosis Care
ClinicalTrials.gov study NCT03044158. IPD Sharing: NO. Countries: 1. Publications: 30.
Byanyima et al- Feasibility and sensitivity of saliva GeneXpert MTBRIF Ultra for tuberculosis diagnosis in Ugandan adults
Open the record for dataset details and reuse information.
GXT - GeneXpert or Chest-X-ray or Tuberculin Skin Testing for Household Contact Assessment
ClinicalTrials.gov study NCT04528823. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Identification of Herpes Simplex Virus (HSV) Shedding in the Female Genital Tract of Pregnant and Nonpregnant Women by GeneXpert PCR, Routine PCR, and Culture
ClinicalTrials.gov study NCT01878383. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Role of Genexpert in Extra Pulmonary Tuberculosis
ClinicalTrials.gov study NCT03173261. IPD Sharing: NO. Countries: 0. Publications: 2.
Application of GeneXpert on Bronchoscopic Samples for Patients Suspicious of TB
ClinicalTrials.gov study NCT02838641. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of GeneXpert Mycobacterium Tuberculosis/ Rifampicin (MTB/RIF) Versus the Routine Methods for Detection of Mycobacterium Tuberculosis
ClinicalTrials.gov study NCT06409572. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Application of GeneXpert on Bronchoscopic Samples in the Clinical Management of Patients Suspicious of TB
ClinicalTrials.gov study NCT02619240. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Xpert® Hemorrhagic Fever on the GeneXpert® Edge X System
ClinicalTrials.gov study NCT07370454. IPD Sharing: NO. Countries: 1. Publications: 0.
Evaluation of GeneXpert HIV-1 as The Gold Standard Test for HIV-1 Viral Load Count
ClinicalTrials.gov study NCT05977010. IPD Sharing: NO. Countries: 1. Publications: 0.
Xpert Hepatitis-C Virus (HCV) Test on the GeneXpert Xpress System
ClinicalTrials.gov study NCT06508996. IPD Sharing: NO. Countries: 1. Publications: 0.
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