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383 results for “Glioblastoma multiforme”
TCGA Glioblastoma Multiforme (GBM) Gene Expression
<p><strong>Abstract:</strong></p> <p>The Cancer Genome Atlas (TCGA) was a large-scale collaborative project initiated by the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI). It aimed to comprehensively characterize the genomic and molecular landscape of various cancer types. This dataset contains information about GBM, an aggressive and highly malignant brain tumor that arises from glial cells, characterized by rapid growth and infiltrative behavior. The gene expression profile was measured experimentally using the Affymetrix HT Human Genome U133a microarray platform by the Broad Institute of MIT and Harvard University cancer genomic characterization center. The Sample IDs serve as unique identifiers for each sample.</p> <p><strong>Inspiration:</strong></p> <p>This dataset was uploaded to UBRITE for GTKB project. </p> <p><strong>Instruction:</strong></p> <p>The log2(x) normalization was removed, and z-normalization was performed on the dataset using a Python script.</p> <p><strong>Acknowledgments:</strong></p> <p>Goldman, M.J., Craft, B., Hastie, M. et al. Visualizing and interpreting cancer genomics data via the Xena platform. Nat Biotechnol (2020). https://doi.org/10.1038/s41587-020-0546-8</p> <p>The Cancer Genome Atlas Research Network., Weinstein, J., Collisson, E. et al. The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet 45, 1113–1120 (2013). https://doi.org/10.1038/ng.2764</p> <p><strong>U-BRITE last update: </strong>07/13/2023</p>
TCGA Glioblastoma Multiforme (GBM) Clinical Data
<p><strong>Abstract:</strong></p> <p>The Cancer Genome Atlas (TCGA) was a large-scale collaborative project initiated by the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI). It aimed to comprehensively characterize the genomic and molecular landscape of various cancer types. This dataset includes curated survival data from the Pan-cancer Atlas paper titled <a href="http://www.cell.com/cell/fulltext/S0092-8674(18)30229-0">"An Integrated TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR) to drive high quality survival outcome analytics"</a>. The paper highlights four types of carefully curated survival endpoints, and <a href="http://www.cell.com/action/showFullTableImage?isHtml=true&tableId=tbl3&pii=S0092867418302290">recommends the use of the endpoints of OS, PFI, DFI, and DSS for each TCGA cancer type</a>. The dataset also includes phenotypic information about GBM. The Sample IDs are unique identifiers, which can be paired with the gene expression dataset. </p> <p><strong>Inspiration:</strong></p> <p>This dataset was uploaded to UBRITE for GTKB project. </p> <p><strong>Instruction:</strong></p> <p>The survival and phenotype data were merged into one file. Empty columns were removed. Columns with the same value for every sample were also removed. </p> <p><strong>Acknowledgments:</strong></p> <p>Goldman, M.J., Craft, B., Hastie, M. et al. Visualizing and interpreting cancer genomics data via the Xena platform. Nat Biotechnol (2020). https://doi.org/10.1038/s41587-020-0546-8</p> <p>Liu, Jianfang, Caesar-Johnson, Samantha J. et al. An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics. Cell, Volume 173, Issue 2, 400 - 416.e11. <a href="https://doi.org/10.1016/j.cell.2018.02.052">https://doi.org/10.1016/j.cell.2018.02.052</a></p> <p>The Cancer Genome Atlas Research Network., Weinstein, J., Collisson, E. et al. The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet 45, 1113–1120 (2013). https://doi.org/10.1038/ng.2764</p> <p><strong>U-BRITE last update: </strong>07/13/2023</p>
Vaccine Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
ClinicalTrials.gov study NCT00643097. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Biological Therapy and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
ClinicalTrials.gov study NCT00052715. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study of PX-866 in Patients With Glioblastoma Multiforme at Time of First Relapse or Progression
ClinicalTrials.gov study NCT01259869. IPD Sharing: NO. Countries: 1. Publications: 1.
Oral Pazopanib Plus Oral Topotecan Metronomic Antiangiogenic Therapy for Recurrent Glioblastoma Multiforme (A) Without Prior Bevacizumab Exposure and (B) After Failing Prior Bevacizumab
ClinicalTrials.gov study NCT01931098. IPD Sharing: NO. Countries: 1. Publications: 3.
Stereotactic Radiosurgery and Radiation Therapy in Treating Patients With Glioblastoma Multiforme
ClinicalTrials.gov study NCT00253448. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Oral Tarceva Study for Recurrent/Residual Glioblastoma Multiforme and Anaplastic Astrocytoma
ClinicalTrials.gov study NCT00301418. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Open Label Trial to Explore Safety of Combining Afatinib (BIBW 2992) and Radiotherapy With or Without Temozolomide in Newly Diagnosed Glioblastoma Multiform
ClinicalTrials.gov study NCT00977431. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Cilengitide (EMD 121974) for Recurrent Glioblastoma Multiforme (Brain Tumor)
ClinicalTrials.gov study NCT00093964. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Radiation Therapy and Temozolomide Followed by Temozolomide Plus Sorafenib for Glioblastoma Multiforme
ClinicalTrials.gov study NCT00544817. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Vorinostat, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
ClinicalTrials.gov study NCT00731731. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Temozolomide in Treating Patients With Recurrent Glioblastoma Multiforme or Other Malignant Glioma
ClinicalTrials.gov study NCT00498927. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Viral Therapy in Treating Patients With Recurrent Glioblastoma Multiforme
ClinicalTrials.gov study NCT00390299. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Dasatinib in Treating Patients With Recurrent Glioblastoma Multiforme or Gliosarcoma
ClinicalTrials.gov study NCT00423735. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Motexafin Gadolinium, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma
ClinicalTrials.gov study NCT00305864. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Phase 2 Trial of High-Dose Ascorbate in Glioblastoma Multiforme
ClinicalTrials.gov study NCT02344355. IPD Sharing: YES. Countries: 1. Publications: 2.
Radiation Therapy With or Without Temozolomide in Treating Older Patients With Newly Diagnosed Glioblastoma Multiforme
ClinicalTrials.gov study NCT00482677. IPD Sharing: NO. Countries: 4. Publications: 3.
Phase II Feasibility Study of Dendritic Cell Vaccination for Newly Diagnosed Glioblastoma Multiforme
ClinicalTrials.gov study NCT00323115. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Erlotinib and Sorafenib in Treating Patients With Progressive or Recurrent Glioblastoma Multiforme
ClinicalTrials.gov study NCT00445588. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.