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92 results for “Glucose production”
Additional file 1 of Medium development and production of carotenoids and exopolysaccharides by the extremophile Rhodothermus marinus DSM16675 in glucose-based defined media
<p>The biodegradative capacity of bacteria in their natural habitats is affected by water availability. In this work, we have examined the activity and effector specificity of the transcriptional regulator XylR of the TOL plasmid pWW0 of Pseudomonas putida mt-2 for biodegradation of m-xylene when external water potential was manipulated with polyethylene glycol PEG8000. By using non-disruptive luxCDEAB reporter technology, we noticed that the promoter activated by XylR (Pu) restricted its activity and the regulator<br> became more effector-specific towards head TOL substrates when cells were grown under water subsaturation. Such a tight specificity brought about by water limitation was relaxed when intracellular osmotic stress was counteracted by the external addition of the compatible solute glycine betaine. With these facts in hand, XylR variants isolated earlier as effectorspecificity responders to the non-substrate 1,2,4-trichlorobenzene under high matric stress were re-examined and found to be unaffected by water potential in vivo. All these phenomena could be ultimately explained as the result of water potential-dependent conformational changes in the A domain of XylR and its effector-binding pocket, as suggested by AlphaFold prediction of protein structures. The consequences of this scenario for the evolution of specificities in regulators and the emergence of catabolic pathways are discussed.</p>
Gene expression data from clones of FAO cells with different glucose production capability
<div> <div> <div> <p>In response to energy and nutrient shortage, the liver triggers several catabolic processes to promote survival. Despite recent progresses, the precise molecular mechanisms regulating the hepatic adaptation to fasting remain incompletely characterized. Here, we report the identification of Hydroxysteroid dehydrogenase-like 2 (HSDL2) as a mitochondrial protein highly induced by fasting. We show that activation of PGC1a-PPARa and inhibition of the PI3K- mTORC1 axis stimulate HSDL2 expression in hepatocytes. We found that HSDL2 depletion decreases cholesterol conversion to bile acids (BAs) and impairs FXR activity. HSDL2 knockdown also reduces mitochondrial respiration, fatty acid oxidation, and TCA cycle activity. Bioinformatics analyses revealed that hepatic Hsdl2 expression positively associates with the postprandial excursion of various BA species in mice. Here, we show that liver-specific HSDL2 depletion impacts BA metabolism and decreases circulating cholesterol levels upon refeeding. Overall, our report identifies HSDL2 as a fasting-induced mitochondrial protein that links nutritional signals to BAs and cholesterol homeostasis.</p> </div> </div> </div>
Effect of Combined Incretin-Based Therapy Plus Canagliflozin on Glycemic Control and the Compensatory Rise in Hepatic Glucose Production in Type 2 Diabetic Patients
ClinicalTrials.gov study NCT02324842. IPD Sharing: Not stated. Countries: 1. Publications: 2.
SGLT2 Inhibition and Stimulation of Endogenous Glucose Production: Protocol 2
ClinicalTrials.gov study NCT02592421. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Sitagliptin Regulation of Intestinal and Hepatic Lipoprotein Particle and Hepatic Glucose Production in Humans
ClinicalTrials.gov study NCT01600703. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Inducible versus constitutive social immunity: examining effects of colony infection on glucose oxidase and defensin-1 production in honeybees
Open the record for dataset details and reuse information.
Gene expression data from clones of FAO cells with different glucose production capability
Open the record for dataset details and reuse information.
Fig. 2 in Agrocinopine C, a Ti-plasmid-coded enzyme-product, is a 2-O, 6-O linked phosphodiester of D-Glucose and sucrose
Fig. 2. Diffuse reflectance mid infra-red spectrum of agrocinopine C. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 4 in Agrocinopine C, a Ti-plasmid-coded enzyme-product, is a 2-O, 6-O linked phosphodiester of D-Glucose and sucrose
Fig. 4. Bioassay detection of agrocinopine C. The left plate shows detection of agrocinopine C in the pH 1.7, anionic paper electrophoretogram segment marked C, by its induction of antibiotic activity in the normally insensitive K478 (syn. A281) overlay, from a source of agrocin 84 produced by the chloroformsterilised, colony of R. rhizogenes strain K84 grown at the centre of both plates. The radius of the normal toxic concentration range of agrocin 84 extends approximately to the location of the paper squares. The right plate demonstrates that glucose 2-phosphate (square A) induces no detectable sensitivity to agrocin 84, glucose 6-phosphate (square B) no detectable sensitivity and purified agrocinopine C (C) induces a very strong uptake of the antibiotic. It is noteworthy that unlike agrocinopine A, which extends the inhibition zone perimeter (Ellis and Murphy, 1981; Ryder et al., 1984) beyond the squares, agrocinopine C only induces sensitivity inwards towards the original agrocin 84 producer colony.
Fig. 3 in Agrocinopine C, a Ti-plasmid-coded enzyme-product, is a 2-O, 6-O linked phosphodiester of D-Glucose and sucrose
Fig. 3. Relative electrophoretic mobilities (RmDNBS) of ribose-5-P (triangle; pKa1 =1.32, pKa2 =6.58), agrocinopine C (circle) and agrocinopine D (square) between pH 1.7 and 10.
Fig. 5 in Agrocinopine C, a Ti-plasmid-coded enzyme-product, is a 2-O, 6-O linked phosphodiester of D-Glucose and sucrose
Fig. 5. (a) 31P NMR signals for agrocinopine C, α/β pyranosyl anomers (-2.80 ppm), α/β furanosyl anomers (-3.24 ppm) and the aldehyde anomer and/or its hydrate (-4.03 ppm). No evidence for a detectable amount of the hydrated aldehyde as a separate 6th signal was observed in these 31P NMR observations. Peaks at -3.09 and -3.12 ppm are not correlated to any agrocinopine C protons by 31P gHMBC. (b) Agrocinopine C31P NMR signals collapse to a singlet after borohydride reduction (-1.55 ppm).
Fig. 6. Structural relationships for agrocinopine C in Agrocinopine C, a Ti-plasmid-coded enzyme-product, is a 2-O, 6-O linked phosphodiester of D-Glucose and sucrose
Fig. 6. Structural relationships for agrocinopine C and its various anomeric equilibria. The presence of the aldehyde anomer and/or its hydrate and α/β pyranosyl and α/β furanosyl anomers is consistent with the three signals detected in the 31P NMR and five anomeric proton signals observed in the 1H NMR (Table 2, Table S1). (ChemBioDraw, 2014).
Impact of Deep Brain Stimulation of Subthalamic Nucleus on the Hepatic Glucose Production in Parkinson's Disease
ClinicalTrials.gov study NCT00663312. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of ANKASCIN 568-P Products on Decreasing HbA1c and Regulating Blood Glucose
ClinicalTrials.gov study NCT05737342. IPD Sharing: NO. Countries: 1. Publications: 9.
Efficacy of Milk Product Supplemented With Bioactives in Lowering Post Meal Glucose Response
ClinicalTrials.gov study NCT05570435. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Investigating the Effect of Liraglutide on the Endogenous Glucose Production During in Tye 1 Diabetes Subjects
ClinicalTrials.gov study NCT02408705. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Determination of the Effect of Extreme Dietary Carbohydrate Restriction on Hepatic Glucose Production
ClinicalTrials.gov study NCT01262326. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Regulation of Endogenous Glucose Production by Central KATP Channels
ClinicalTrials.gov study NCT03540758. IPD Sharing: NO. Countries: 1. Publications: 0.
Regulation of Intestinal and Hepatic Lipoprotein Particle Production by Blood Glucose in Humans
ClinicalTrials.gov study NCT02607839. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Pasta and Other Durum Wheat-based Products: Effects on Post-prandial Glucose Metabolism
ClinicalTrials.gov study NCT03024983. IPD Sharing: NO. Countries: 1. Publications: 15.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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