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79 results for “Glycocalyx”
Evaluation of Endothelial Glycocalyx in the Surgical Resuscitation of Major Burn Patients
ClinicalTrials.gov study NCT06670248. IPD Sharing: YES. Countries: 1. Publications: 13.
Effects of Agonists of Glucagon Like Peptide - 1 Receptors (GLP-1R) on Arterial Stiffness, Endothelial Glycocalyx and Coronary Flow Reserve in Patients With Coronary Artery Disease and Patients With D
ClinicalTrials.gov study NCT03010683. IPD Sharing: NO. Countries: 1. Publications: 2.
Dataset related to: Endothelial Glycocalyx of Peritubular Capillaries in Experimental Diabetic Nephropathy: A Target of ACE Inhibitor-Induced Kidney Microvascular Protection
<p>The files contain all the dataset included in the manuscript divided by figures.</p> <p> </p> <p>Abstract: Peritubular capillary rarefaction is a recurrent aspect of progressive nephropathies. We previously found that peritubular capillary density was reduced in BTBR <em>ob</em>/<em>ob</em> mice with type 2 diabetic nephropathy. In this model, we searched for abnormalities in the ultrastructure of peritubular capillaries, with a specific focus on the endothelial glycocalyx, and evaluated the impact of treatment with an angiotensin-converting enzyme inhibitor (ACEi). Mice were intracardially perfused with lanthanum to visualise the glycocalyx. Transmission electron microscopy analysis revealed endothelial cell abnormalities and basement membrane thickening in the peritubular capillaries of BTBR <em>ob</em>/<em>ob</em> mice compared to wild-type mice. Remodelling and focal loss of glycocalyx was observed in lanthanum-stained diabetic kidneys, associated with a reduction in glycocalyx components, including sialic acids, as detected through specific lectins. ACEi treatment preserved the endothelial glycocalyx and attenuated the ultrastructural abnormalities of peritubular capillaries. In diabetic mice, peritubular capillary damage was associated with an enhanced tubular expression of heparanase, which degrades heparan sulfate residues of the glycocalyx. Heparanase was also detected in renal interstitial macrophages that expressed tumor necrosis factor-α. All these abnormalities were mitigated by ACEi. Our findings suggest that, in experimental diabetic nephropathy, preserving the endothelial glycocalyx is important in order to protect peritubular capillaries from damage and loss.</p>
Data from: Diosmin and its glycocalyx restorative and anti-inflammatory effects on injured blood vessels
<p>Endothelium, a crucial homeostatic organ, regulates vascular permeability and tone. Under physiological conditions, endothelial stimulation induces vasodilator endothelial nitric oxide (eNO) release and prevents adhesion molecule accessibility and leukocyte adhesion and migration into vessel walls. Endothelium dysfunction is a principal event in cardiovascular disorders, including atherosclerosis. Hence, current therapies focus on endothelium repair to prevent downstream cardiovascular events. However, minimal attention is given to the restoration of mechanotransducer endothelial glycocalyx (GCX), a negatively charged heterogeneous polysaccharide, which covers and protects endothelial cells. Endothelial GCX shedding plays a role in endothelial dysfunction, increasing vascular permeability and decreasing vessel tone. Diosmin, a flavone glycoside of diosmetin, downregulates adhesive molecule expression, decreases inflammation and capillary permeability, and upregulates eNO expression. Due to these pleiotropic effects of diosmin on the vasculature, a possible unidentified mechanism of action is through GCX restoration. Diosmin effect on GCX and endothelial function were assessed in a partial ligation left carotid artery (LCA) mouse model where the right carotid artery was the control for each mouse. Diosmin (50 mg/kg) was administered daily for 7 days, 48 hours after ligation. Within the ligated mice LCAs, diosmin treatment elevated the activated eNO synthase level, inhibited inflammatory cell uptake, decreased vessel wall thickness, increased vessel diameter, and increased GCX coverage of the vessel wall. ELISA showed a decrease in hyaluronan concentration in plasma samples of diosmin-treated mice, signifying reduced GCX shedding. In summary, diosmin supported endothelial GCX integrity, which preserved endothelial function by attenuating expression of inflammatory factors and restoring vascular tone.</p>
Glycocalyx During Normothermic Machine Perfusion
ClinicalTrials.gov study NCT04764266. IPD Sharing: NO. Countries: 1. Publications: 0.
Early Detection of Glycocalyx Damage in Emergency Room Patients
ClinicalTrials.gov study NCT03126032. IPD Sharing: NO. Countries: 1. Publications: 0.
The Effect of Dietary Intervation on Endothelial Glycocalyx in COVID-19 Patients.
ClinicalTrials.gov study NCT05185934. IPD Sharing: NO. Countries: 1. Publications: 1.
Dietary Interventions on Glycocalyx Dimensions in South Asian Patients With Diabetic Nephropathy.
ClinicalTrials.gov study NCT03889236. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effects of I Quit Ordinary Smoking on the Arterial Wall and Endothelial Glycocalyx Properties of Smokers
ClinicalTrials.gov study NCT03452124. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Degradation of the Glycocalyx in Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage
ClinicalTrials.gov study NCT03706768. IPD Sharing: UNDECIDED. Countries: 1. Publications: 28.
Glycocalyx Damage and Beta-lactam Antibiotics in Surgical Critically Ill
ClinicalTrials.gov study NCT03136796. IPD Sharing: NO. Countries: 1. Publications: 2.
The Effect of Total Intravenous Anesthesia and Volatile Anesthesia on Shedding of the Endothelial Glycocalyx in Patients Undergoing Laparoscopic or Robotic Assisted Gastrectomy
ClinicalTrials.gov study NCT04183296. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Dexmedetomidine to Prevent Hepatic Ischemia-reperfusion Injury-induced Glycocalyx Degradation and Early Allograft Dysfunction in Liver Transplantation
ClinicalTrials.gov study NCT05031026. IPD Sharing: Not stated. Countries: 1. Publications: 4.
The Effect of Balanced Crystalloid Versus 5% Albumin on Endothelial Glycocalyx Degradation in Patients Undergoing Off-pump Coronary Artery Bypass Surgery
ClinicalTrials.gov study NCT03699462. IPD Sharing: NO. Countries: 1. Publications: 1.
The Effect of Dietary Intervention on Endothelial Glycocalyx in Psoriasis
ClinicalTrials.gov study NCT05184699. IPD Sharing: NO. Countries: 1. Publications: 1.
Perioperative Plasma Levels of Glycocalyx Markers in Colon Surgery.
ClinicalTrials.gov study NCT05419882. IPD Sharing: NO. Countries: 1. Publications: 19.
0,9% NaCl Effect on Kidney Function and Glycocalyx in Patients Operated on for Primary Hiparthrosis
ClinicalTrials.gov study NCT02528448. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Role of Glycocalyx Integrity in the Primary Prevention of Major Cardiovascular Events
ClinicalTrials.gov study NCT04646252. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effect of Restrictive Fluid Management on Cardiac Function and Glycocalyx Degradation
ClinicalTrials.gov study NCT04282252. IPD Sharing: NO. Countries: 1. Publications: 1.
The Effects of Electronic Cigarette Smoking on the Arterial Wall and Endothelial Glycocalyx Properties of Smokers
ClinicalTrials.gov study NCT03039920. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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International Brain Laboratory public data
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OpenNeuro
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