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74 results for “Gold nanoparticles”

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zenodo44/100

Tilt-series 4DSTEM dataset of DNA origami with gold nanoparticles

<p>Raw TEM data for the manuscript "Three-dimensional Electron Ptychography of Organic-inorganic Hybrid Nanostructures".</p>

opencc-by-4.0Jul 2022View details →
zenodo44/100

Data: Stability and biological response of PEGylated gold nanoparticles

<p><span>This dataset is focused on thermal stability of PEGylated Au NPs at 4 and 37 &deg;C and after sterilization in autoclave.</span></p>

opencc-by-4.0May 2024View details →
zenodo44/100

DATASET: Predicting Protein Function and Orientation on a Gold Nanoparticle Surface Using a Residue-Based Affinity Scale

<p>This upload contains data for the manuscript &quot;<strong>Predicting Protein Function and Orientation on a Gold Nanoparticle Surface Using a Residue-Based Affinity Scale</strong>.&quot; It contains kinetics data, UV-vis data, surface calculations, and activity assays for the systems described in the manuscript.</p>

opencc-by-4.0Oct 2022View details →
zenodo40/100

Topology and structure of Au144(SRNH3+)60 from "Atomistic Simulations of Functional Au144(SR)60 Gold Nanoparticles in Aqueous Environment"

<p>Positively&nbsp;charged monolayer-protected gold nanoparticles (AuNPs) structure&nbsp;and topology files for GROMACS&nbsp;used in DOI:&nbsp;10.1021/jp301094m. &nbsp;The final structure of&nbsp;the simulation&nbsp;reported in&nbsp;DOI: 10.1021/jp301094m&nbsp;for the neutral case is&nbsp;provided.</p> <p>The&nbsp;gold nanoparticle contain a core of 144&nbsp;Au&nbsp;atoms and&nbsp;60&nbsp;functionalized alkanethiol side groups (undecanyl chain, R = C11H22), each possessing a positively charged amonium&nbsp;terminal group.</p> <p>When using this structure do not forget to cite&nbsp;DOI:&nbsp;10.1021/jp301094m.&nbsp;</p> <p>NOTE1: Different versions for the topology files are provided of both&nbsp;AuNPs. All versions were used for the publication. The changes only affect the core surface and therefore had no influence in the reported properties. Still we recommentd using the latest version:&nbsp;AU144SRNH360_v3.itp.</p> <p>NOTE2: The original simulations used GROMACS&nbsp;4.0.5. The files should work, however, as well up to GROMACS&nbsp;4.6.7.</p>

opencc-by-4.0Apr 2012View details →
zenodo40/100

Topology and structure of Au144(SRCOO-)60 from "Atomistic Simulations of Functional Au144(SR)60 Gold Nanoparticles in Aqueous Environment"

<p>Negatively charged monolayer-protected gold nanoparticles (AuNPs) structure&nbsp;and topology files for GROMACS&nbsp;used in DOI:&nbsp;10.1021/jp301094m. &nbsp;The final structure of&nbsp;the simulation&nbsp;reported in&nbsp;DOI: 10.1021/jp301094m&nbsp;for the neutral case is&nbsp;provided.</p> <p>The&nbsp;gold nanoparticle contain a core of 144&nbsp;Au&nbsp;atoms and 60&nbsp;functionalized alkanethiol side groups (undecanyl chain, R = C11H22), each possessing a negatively charged carboxylic&nbsp;terminal group.</p> <p>When using this structure do not forget to cite DOI:&nbsp;10.1021/jp301094m.&nbsp;</p> <p>NOTE1: Different versions for the topology files are provided of both&nbsp;AuNPs. All versions were used for the publication. The changes only affect the core surface and therefore had no influence in the reported properties. Still we recommentd using the latest version:&nbsp;AU144SRCOO60_v2.itp.</p> <p>NOTE2: The original simulations used GROMACS&nbsp;4.0.5. The files should work, however, as well up to GROMACS&nbsp;4.6.7.</p>

opencc-by-4.0Apr 2012View details →
zenodo40/100

Determination of antibacterial and photothermal properties of novel composites based on graphene oxide/reduced graphene oxide, gold nanoparticles, and graphene quantum dots

<p>HR-TEM.zip - HR-TEM files, file type .jpg</p> <p>FTIR.zip - FTIR spectra, file type .spa</p> <p>Photoluminescence.zip - PL spectra, file type .opju</p> <p>UV-Vis.opju - Origin file with UV-Vis spectra combined</p> <p>Raman 532 nm.opju - Origin file with Raman spectra combined</p> <p>ABDA.opju - Origin file with singlet oxygen production measurements</p> <p>Contact angle.png - Image with contact angle values</p> <p>Antibacterial analysis.png - Image representing antibacterial growth inhibition analysis</p> <p>XRD.zip - XRD spectra, file type .dat</p>

opencc-by-4.0Oct 2024View details →
zenodo40/100

Gold Nanoparticles Synthesized in the Presence of Peptides - UV-Vis Spectra, Fluorescence, USAXS, Electron Microscopy

<p>Content Summary:</p> <ul> <li>Data from experiments in which gold nanoparticles were synthesized in the presence of peptides using a liquid-handling robot. Samples were analyzed using UV-Vis spectroscopy, fluorescence emission, USAXS, TEM, and SEM.&nbsp;</li> <li>Notebooks for loading and plotting data</li> <li>Code for synthesizing samples using an OT2 Opentrons liquid-handling robot.</li> </ul> <p>README:</p> <p><strong>/Data</strong></p> <p>Contains all UV-Vis, electron microscopy, fluorescence, and SAXS data for gold nanoparticles synthesized in the presence of peptides and HEPES.</p> <p><strong>/Data/2021_12_30_Prepared_UV_Vis_Data</strong></p> <p>The primary portion of the experimental dataset. UV-Vis spectroscopy data collected on a Biotek Epoch 2 microplate spectrophotometer 24 hours after samples were synthesized using a liquid handling robot (Opentrons OT2). The <strong>4x4x4_SI.csv </strong>file is the compilation of all sample information:</p> <ul> <li>Concentrations (M) of peptide, HAuCl4, and HEPES</li> <li>UID &ndash; unique ID based on date of synthesis, sample position, and peptide which was used to synthesize the sample.</li> <li>Peptide names: Z2: RMRMKMK; MZ2: myristoylated - RMRMKMK; MZ2R: myristoylated - KMKMRMR; PZ2: palmitoylated &ndash; RMRMKMK; Z2M6I: RMRMKIK; Z2M246I: RIRIKIK; AG3: AYSSGAPPMPPF.</li> </ul> <p>Each sample&rsquo;s UID is a key to match with UV-Vis measurement result stored in the {<strong>UID}.txt </strong>files. Each of these files contains the wavelength, absorbance, and absorbance after subtraction of a water measurement.</p> <p><strong>/Data/2022_02_13_AuPeptide_Kinetics</strong></p> <p><strong>Measurement_Data.xlsx</strong> and <strong>Measurement_Times.xlsx </strong>contain UV-Vis spectra at several time points for each well measured, and the time corresponding to each time step, respectively. See <strong>/Notebooks/UV_Vis_Kinetics.ipynb</strong> for data plotting and sample concentration information.</p> <p><strong>/Data/ElectronMicroscopy</strong></p> <p>Scanning electron microscopy and transmission electron microscopy results of gold nanoparticles formed from the reduction of HAuCl4 in the presence or absence of different peptides.</p> <p>Fig A, B, C, D, E/F were prepared in the presence of Z2, Z2M6I, Z2M246I, no peptide, and MZ2R, respectively.</p> <p><strong>/Data/Fluorescence</strong></p> <p>Pyrene fluorescence data collected in the presence of different concentrations of lipidated peptides (MZ2, MZ2R, and PZ2) for estimation of the peptide critical micelle concentration.</p> <p><strong>/Data/SAXS</strong></p> <p>SAXS data of a high concentration of MZ2 which was fit using a cylindrical model form factor. The evaluated model is also shared in this directory.</p> <p><strong>/Data/USAXS</strong></p> <p>Similarly to the UV-Vis data directory, the <strong>USAXS_SI.csv</strong> file contains sample information for all of the USAXS measurements. The <strong>dsm_rg.csv</strong> file contains the output of AUTORG evaluated on the desmeared data after subtraction of a flat background at high-q. <strong>/DSM_Nexus, DSM_sub_AUTORG, </strong>and <strong>SMR_Nexus</strong> contain the desmeared, desmeared with background subtraction, and smeared versions of the USAXS data, respectively.</p> <p><strong>/Notebooks</strong></p> <p>Notebooks for plotting the shared data and estimating the CMC from the fluorescence data. See <strong>/Notebooks/environment.yml</strong> for packages necessary to execute the notebooks here and in <strong>/Synthesis_Protocol</strong>. We recommend installing this environment by using:</p> <p>conda env create -f /environment.yml</p> <p>Refer to&nbsp; <a href="https://github.com/SasView/sasmodels">https://github.com/SasView/sasmodels</a> and the first cell of <strong>/Notebooks/USAXS.ipynb</strong> for specific instructions on how to complete installation of the sasmodels module (sasmodels will be installed by Pip if you correctly use the shared environment.yml file).</p> <p><strong>/Figures</strong></p> <p>Figures generated from <strong>/Notebooks</strong>.</p> <p><strong>/Synthesis_Protocol</strong></p> <p>Please read the instructions within <strong>/Synthesis_Procol/Example.ipynb</strong>. In short, this folder contains the code used to synthesize the samples in this dataset using an OT2 Opentrons liquid handling robot.</p> <p>&nbsp;</p>

opencc-by-4.0May 2022View details →
zenodo40/100

X-ray scattering Datasets of gold and silver nanoparticle composites, relating to the publication "Gold and silver dichroic nanocomposite in the quest for 3D printing the Lycurgus cup"

<p>Wide-range X-ray scattering datasets and analyses&nbsp;for all samples described in the 2020 publication &quot;Gold and silver dichroic nanocomposite in the quest for 3D printing the Lycurgus cup&quot;. These datasets are composed by combining multiple small-angle x-ray scattering and wide-angle x-ray scattering curves into a single dataset. They have been analyzed using McSAS to extract polydispersities and volume fractions. They have been collected using the MOUSE project (instrument and methodology).&nbsp;</p> <p>&nbsp;</p>

opencc-by-4.0Dec 2021View details →
zenodo40/100

FDTD simulation of 290 nm PAAO with gold nanoparticles: varying incidence angle, s-polarization, n=1

<p>Version 2 has the same files as version 1 and some additional files.</p> <p>FDTD software: Lumerical (Ansys, version 2021 R2.3).</p> <p>Structure: aluminum (Palik) substrate; 290 nm thickness (<em>h</em>) aluminum oxide (Palik) layer with 35 nm diameter (<em>RPo</em>) cylindrical pores with 100 nm&nbsp;distance (<em>D</em>) between the pore centers (representing porous anodized aluminum oxide - PAAO); 60 nm diameter (<em>RNP</em>) gold (Johnson and Christy) nanoparticles placed directly above each pore.</p> <p>Refractive index of the surrounding medium (<em>n</em>): 1.0.</p> <p>Simulation region: from 300 nm below the substrate/PAAO interface to 1.3 &micro;m above PAAO surface; x and y spans are equal to one period of the structure.</p> <p>Mesh override region: from 50 nm below the PAAO to 50 nm above the nanoparticles; 2 nm step size in each direction.</p> <p>Light source: BFAST plane wave light source; 500 nm above PAAO; varying (20&deg; - 70&deg; in steps of 5&deg;) angle of incidence (<em>ang</em>); 300 nm &ndash; 1000 nm wavelength range; s-polarization (<em>pol</em>).</p> <p>Monitor (frequency domain field and power): 2D Z-normal; 1 &micro;m above PAAO; results are in &quot;<em>_reflection.txt</em>&quot; files.</p> <p>Information in the file name: <em>h</em> - thickness of PAAO; <em>pol</em> - polarization; <em>RNP</em> - diameter of gold nanoparticles; <em>RPo</em> - diameter of pores; <em>D</em> - distance between pore centers; <em>ang</em> - angle of incidence; <em>n</em> - refractive index of surrounding medium.</p> <p>Files: (1) &quot;<em>_reflection.txt</em>&quot; - lambda(nm) (first column) - wavelength in nanometers; Y (second column) - T data from the monitor above the structure. (2) &quot;<em>_p0.log</em>&quot; - log file produced by the software while running the simulation. (3) &quot;<em>.fsp</em>&quot; - Lumerical software file containing the simulation project (license required to open these files). Consecutive numbering corresponds to the angles of incidence: 1 - 20&deg;, 2 - 25&deg;, 3 - 30&deg;, 4 - 35&deg;, 5 - 40&deg;, 6 - 45&deg;, 7 - 50&deg;, 8 - 55&deg;, 9 - 60&deg;, 10 - 65&deg;, 11 - 70&deg;. (4) &quot;<em>Lumerical_Screenshots.pdf</em>&quot; - shows software screenshots for every object and its every property; red text is added to show which values are different for different simulations. (5) &quot;<em>Structure_Illustration.png</em>&quot; - a schematic of modeled structure. (6) &quot;290nm-Spol_varying-angle<em>.jpg</em>&quot; - a preview of data from &quot;<em>_reflection.txt</em>&quot; files.</p>

opencc-by-4.0May 2022View details →
zenodo40/100

FDTD simulation of 290 nm PAAO with gold nanoparticles: varying refractive index of surrounding medium, s-polarization

<p>Version 2 has the same files as version 1 and some additional files.</p> <p>FDTD software: Lumerical (Ansys, version 2021 R2.3).</p> <p>Structure: aluminum (Palik) substrate; 290 nm thickness (<em>h</em>) aluminum oxide (Palik) layer with 35 nm diameter (<em>RPo</em>) cylindrical pores with 100 nm&nbsp;distance (<em>D</em>) between the pore centers (representing porous anodized aluminum oxide - PAAO); 60 nm diameter (<em>RNP</em>) gold (Johnson and Christy) nanoparticles placed directly above each pore.</p> <p>Refractive index of the surrounding medium (<em>n</em>): 1.0; 1.1; 1.2; 1.3.</p> <p>Simulation region: from 300 nm below the substrate/PAAO interface to 1.3 &micro;m above PAAO surface; x and y spans are equal to one period of the structure.</p> <p>Mesh override region: from 50 nm below the PAAO to 50 nm above the nanoparticles; 2 nm step size in each direction.</p> <p>Light source: BFAST plane wave light source; 500 nm above PAAO; 45&deg; angle of incidence (<em>ang</em>); 300 nm &ndash; 1000 nm wavelength range; s-polarization (<em>pol</em>).</p> <p>Monitor (frequency domain field and power): 2D Z-normal; 1 &micro;m above PAAO; results are in &quot;<em>_reflection.txt</em>&quot; files.</p> <p>Information in the file name: <em>h</em> - thickness of PAAO; <em>pol</em> - polarization; <em>RNP/AuRNP</em> - diameter of gold nanoparticles; <em>RPo</em> - diameter of pores; <em>D</em> - distance between pore centers; <em>ang</em> - angle of incidence; <em>n</em> - refractive index of surrounding medium.</p> <p>Files: (1) &quot;<em>_reflection.txt</em>&quot; - lambda(nm) (first column) - wavelength in nanometers; Y (second column) - T data from the monitor above the structure. (2) &quot;<em>_p0.log</em>&quot; - log file produced by the software while running the simulation. (3) &quot;<em>.fsp</em>&quot; - Lumerical software file containing the simulation project; it can be used to extract data from Y- and X-normal monitors (license required to open these files). (4) &quot;<em>Lumerical_Screenshots.pdf</em>&quot; - shows software screenshots for every object and its every property; red text is added to show which values are different for different simulations. (5) &quot;<em>Structure_Illustration.png</em>&quot; - a schematic of modeled structure. (6) &quot;<em>h290,varN.jpg</em>&quot; - a preview of data from &quot;<em>_reflection.txt</em>&quot; files.</p>

opencc-by-4.0May 2022View details →
zenodo40/100

FDTD simulation of PAAO with gold nanoparticles: varying thickness, s-polarization

<p>Version 2 has the same files as version 1 and some additional files.</p> <p>FDTD software: Lumerical (Ansys, version 2021 R2.3).</p> <p>Structure: aluminum (Palik) substrate; 230/260/290/320/350/500 nm thickness (<em>h</em>) aluminum oxide (Palik) layer with 35 nm diameter (<em>RPo</em>) cylindrical pores with 100 nm&nbsp;distance (<em>D</em>) between the pore centers (representing porous anodized aluminum oxide - PAAO); 60 nm diameter (<em>RNP</em>) gold (Johnson and Christy) nanoparticles placed directly above each pore.</p> <p>Refractive index of the surrounding medium: 1.0.</p> <p>Simulation region: from 300 nm below the substrate/PAAO interface to 1.3 &micro;m above PAAO surface; x and y spans are equal to one period of the structure.</p> <p>Mesh override region: from 50 nm below the PAAO to 50 nm above the nanoparticles; 2 nm step size in each direction.</p> <p>Light source: BFAST plane wave light source; 500 nm above PAAO; 45&deg; angle of incidence (<em>ang</em>); 300 nm &ndash; 1000 nm wavelength range; s-polarization (<em>pol</em>).</p> <p>Monitor (frequency domain field and power): 2D Z-normal; 1 &micro;m above PAAO; results are in &quot;<em>_reflection.txt</em>&quot; files.</p> <p>Information in the file name: <em>h</em> - thickness of PAAO; <em>pol</em> - polarization; <em>RNP</em> - diameter of gold nanoparticles; <em>RPo</em> - diameter of pores; <em>D</em> - distance between pore centers; <em>ang</em> - angle of incidence; <em>n</em> - refractive index of surrounding medium (if there is no <em>n</em> in the file name, then <em>n</em> = 1.0).</p> <p>Files: (1) &quot;<em>_reflection.txt</em>&quot; - lambda(nm) (first column) - wavelength in nanometers; Y (second column) - T data from the monitor above the structure. (2) &quot;<em>_p0.log</em>&quot; - log file produced by the software while running the simulation. (3) &quot;<em>.fsp</em>&quot; - Lumerical software file containing the simulation project. (4) &quot;<em>Lumerical_Screenshots.pdf</em>&quot; - shows software screenshots for every object and its every property; red text is added to show which values are different for different simulations. (5) &quot;<em>Structure_Illustration.png</em>&quot; - a schematic of modeled structure. (6) &quot;<em>diff_PAAO_thickness_Spol.jpg</em>&quot; - a preview of data from &quot;<em>_reflection.txt</em>&quot; files.</p>

opencc-by-4.0May 2022View details →
zenodo36/100

V79 fibroblasts loaded with 50 nm PVP-coated gold nanoparticles

<p>Hamster fibroblasts were perfused with 50nm PVP-coated gold nanoparticles and captured by CytoViva darkfield micorscopy (30 FPS, 160nm),</p>

opencc-by-4.0Nov 2016View details →
zenodo36/100

Data to our paper "Water-soluble ionic carbon nitride as unconventional stabilizer for highly catalytically active ultrafine gold nanoparticles"

<p>Data to our paper &quot;Water-soluble ionic carbon nitride as unconventional stabilizer for highly catalytically active ultrafine gold nanoparticles&quot;</p>

opencc-by-4.0Jul 2023View details →
zenodo36/100

Gold nanoparticles - results AuNRs@PEG

<p>This work was supported by the National Science Center in Poland by the project 2021/41/N/ST4/03017</p>

opencc-by-4.0Apr 2023View details →
zenodo36/100

Cellular uptake of silica and gold nanoparticles induces early activation of nuclear receptor NR4A1

<p>The approval of new nanomedicines requires a deeper understanding of the interaction between cells and nanoparticles (NPs). Silica (SiO<sub>2</sub>) and gold (Au) NPs have shown great potential in biomedical applications, such as the delivery of therapeutic agents, diagnostics, and biosensors. NP-cell interaction and internalization can trigger several cellular responses, including gene expression regulation. The identification of differentially expressed genes in response to NP uptake contributes to a better understanding of the cellular processes involved, including potential side effects. We investigated gene regulation in human macrophages and lung epithelial cells after acute exposure to spherical 60 nm SiO<sub>2</sub> NPs. SiO<sub>2</sub> NPs uptake did not considerably affect gene expression in epithelial cells, whereas five genes were up-regulated in macrophages. These genes are principally related to inflammation, chemotaxis, and cell adhesion. NR4A1, an important modulator of inflammation in macrophages, was found to be up-regulated. The expression of this gene was increased upon 1 h of macrophage exposure to spherical 50 nm AuNPs and 200 nm spherical SiO<sub>2</sub> NPs. NR4A1 can thus be an important immediate regulator of inflammation provoked by NP uptake in macrophages.</p>

opencc-by-4.0Feb 2022View details →
zenodo36/100

Gold Nanoparticles Synthesized in the Presence of Peptides - UV-Vis Spectra, Fluorescence, USAXS, Electron Microscopy; pre-publication version

<p>Content Summary:</p> <ul> <li>Data from experiments in which gold nanoparticles were synthesized in the presence of peptides using a liquid-handling robot. Samples were analyzed using UV-Vis spectroscopy, fluorescence emission, USAXS, TEM, and SEM.&nbsp;</li> <li>Notebooks for loading and plotting data</li> <li>Code for synthesizing samples using an OT2 Opentrons liquid-handling robot.</li> </ul> <p>README:</p> <blockquote> <p><strong>/Data</strong></p> <p>Contains all UV-Vis, electron microscopy, fluorescence, and SAXS data for gold nanoparticles synthesized in the presence of peptides and HEPES.</p> <p><strong>/Data/2021_12_30_Prepared_UV_Vis_Data</strong></p> <p>The primary portion of the experimental dataset. UV-Vis spectroscopy data collected on a Biotek Epoch 2 microplate spectrophotometer 24 hours after samples were synthesized using a liquid handling robot (Opentrons OT2). The <strong>4x4x4_SI.csv </strong>file is the compilation of all sample information:</p> <ul> <li>Concentrations (M) of peptide, HAuCl4, and HEPES</li> <li>UID &ndash; unique ID based on date of synthesis, sample position, and peptide which was used to synthesize the sample.</li> <li>Peptide names: Z2: RMRMKMK; MZ2: myristoylated - RMRMKMK; MZ2R: myristoylated - KMKMRMR; PZ2: palmitoylated &ndash; RMRMKMK; Z2M6I: RMRMKIK; Z2M246I: RIRIKIK; AG3: AYSSGAPPMPPF.</li> </ul> <p>Each sample&rsquo;s UID is a key to match with UV-Vis measurement result stored in the {<strong>UID}.txt </strong>files. Each of these files contains the wavelength, absorbance, and absorbance after subtraction of a water measurement.</p> <p><strong>/Data/ElectronMicroscopy</strong></p> <p>Scanning electron microscopy and transmission electron microscopy results of gold nanoparticles formed from the reduction of HAuCl4 in the presence or absence of different peptides.</p> <p>Fig A, B, C, D, E/F were prepared in the presence of Z2, Z2M6I, Z2M246I, no peptide, and MZ2R, respectively.</p> <p><strong>/Data/Fluorescence</strong></p> <p>Pyrene fluorescence data collected in the presence of different concentrations of lipidated peptides (MZ2, MZ2R, and PZ2) for estimation of the peptide critical micelle concentration.</p> <p><strong>/Data/SAXS</strong></p> <p>SAXS data of a high concentration of MZ2 which was fit using a cylindrical model form factor. The evaluated model is also shared in this directory.</p> <p><strong>/Data/USAXS</strong></p> <p>Similarly to the UV-Vis data directory, the <strong>USAXS_SI.csv</strong> file contains sample information for all of the USAXS measurements. The <strong>dsm_rg.csv</strong> file contains the output of AUTORG evaluated on the desmeared data after subtraction of a flat background at high-q. <strong>/DSM_Nexus, DSM_sub_AUTORG, </strong>and <strong>SMR_Nexus</strong> contain the desmeared, desmeared with background subtraction, and smeared versions of the USAXS data, respectively.</p> <p><strong>/Notebooks</strong></p> <p>Notebooks for plotting the shared data and estimating the CMC from the fluorescence data. See <strong>/Notebooks/environment.yml</strong> for packages necessary to execute the notebooks here and in <strong>/Synthesis_Protocol</strong>. Refer to&nbsp; <a href="https://github.com/SasView/sasmodels">https://github.com/SasView/sasmodels</a> for specific instructions on how to install the sasmodels module.</p> <p><strong>/Figures</strong></p> <p>Figures generated from <strong>/Notebooks</strong>.</p> <p><strong>/Synthesis_Protocol</strong></p> <p>Please read the instructions within <strong>/Synthesis_Procol/Example.ipynb</strong>. In short, this folder contains the code used to synthesize the samples in this dataset using an OT2 Opentrons liquid handling robot.</p> <p>&nbsp;</p> </blockquote>

opencc-by-4.0Feb 2022View details →
dryad36/100

Atropine-functionalised gold nanoparticles binding to muscarinic receptors after passage across the intestinal epithelium

<p>Gold nanoparticles have a high potential to be a treatment of diseases by their specific drug delivery properties and multivalent receptor stimulation. For the present project, spherical gold nanoparticles were synthesised and functionalised with the muscarinic receptor antagonist atropine (Au-MUDA-AT NPs). The diameter of the gold core could precisely be controlled by using different synthetic methods and reducing agents resulting in functionalised gold nanoparticles with diameters ranging from 8 to 16 nm. The ability to interact with intestinal muscarinic receptors is size-dependent. When using intestinal chloride secretion induced by the stable acetylcholine derivative, carbachol, as read-out, the strongest inhibition, i.e. the most efficient blockade of muscarinic receptors, was observed with 13 nm sized Au-MUDA-AT NPs. Functional experiments indicate that Au-MUDA-AT NPs with a diameter of 14 nm are able to pass the intestinal mucosa in a time-dependent manner after administration to the intestinal lumen. For example, luminally administered Au-MUDA-AT NPs inhibited contractions of the small intestinal longitudinal muscle layer induced by electrical stimulation of myenteric neurons. A similar inhibition of basolateral epithelial receptors was observed after luminal administration of Au-MUDA-AT NPs when using carbachol-induced chloride secretion across the intestinal epithelium as a test system. Thus, Au-MUDA-AT NPs might be a therapeutic tool for the modulation of intestinal secretion and motility after oral application in the future.</p>

opencc-zeroApr 2022View details →
zenodo36/100

Monovalent ion-mediated charge-charge interactions drive aggregation of surface-functionalized gold nanoparticles

<p>Dataset containing files required to run the simulations in &quot;Monovalent ion-mediated charge-charge interactions drive aggregation of surface-functionalized gold nanoparticles&quot;</p>

opencc-by-4.0Aug 2022View details →
zenodo36/100

Transcriptomics data and script for publication "Unexpected intracellular biodegradation and recrystallization of gold nanoparticles"

<p>Transcriptomics data from DNA arrays sequencing</p> <p>Folder name : Raw_data_DNA_arrays.zip</p> <p>Number of files : 18 .cel files</p> <p>&nbsp;</p> <p>R script for DNA array analysis</p> <p>File name : Clean_Script.R</p>

opencc-by-4.0Nov 2019View details →
zenodo36/100

Supplementary Movies for the article "The fragmentation mechanism of gold nanoparticles in water under femtosecond laser irradiation"

<p>Supplementary movies for&nbsp;the publication &quot;The fragmentation mechanism of gold nanoparticles in water under femtosecond laser irradiation&quot;,&nbsp;<a href="https://doi.org/10.1039/D1NA00406A">https://doi.org/10.1039/D1NA00406A</a>.</p> <p>The movies show gold nanoparticles in water under pulsed laser irradiation and are recorded with&nbsp;<em>in situ </em>liquid cell&nbsp;electron microscopy. The full description of every movie can be found in the &quot;Supplementary Information&quot; file at&nbsp;<a href="https://doi.org/10.1039/D1NA00406A">https://doi.org/10.1039/D1NA00406A</a>.</p>

opencc-by-4.0Oct 2021View details →

ScienceDex guides

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Allen Brain Atlas

Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.

allen-brain-atlas
neuroscienceopenDocumentation, web resources, and API references are available online.
Last verified 2026-04-30Open record

Annotated Behaviour and Observability Dataset (ABODe)

ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.

abode-home-cage
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Last verified 2026-04-30Open record

DANDI Archive for NWB datasets

DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.

dandi-nwb
electrophysiologyopenPublished Dandiset metadata and archive endpoints are available through the production DANDI API.
Last verified 2026-04-30Open record

International Brain Laboratory public data

The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.

ibl
behavioral-neuroscienceopenPublic sessions can be searched and loaded from the IBL public data server through ONE.
Last verified 2026-04-29Open record

OpenNeuro

OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.

openneuro
neuroscienceopenPublished datasets are available on demand over the internet.
Last verified 2026-04-29Open record