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8 results for “HCN channels”
Data: Weak Cation Selectivity in HCN Channels Results from K+-mediated release of Na+ from selectivity filter binding sites
<p>Complementary data for the paper: Weak Cation Selectivity in HCN Channels Results from K+-mediated release of Na+ from selectivity filter binding sites.</p>
The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels control spontaneous electrical activity in heart and brain. Binding of cAMP to the cyclic nucleotide-binding domain (CNBD) facilitates channel opening by relieving a tonic inhibition exerted by the CNBD. Despite high resolution structures of the HCN1 channel in the cAMP bound and unbound states, the structural mechanism coupling ligand binding to channel gating is unknown. Here we show that the recently identified helical HCN-domain (HCND) mechanically couples the CNBD and channel voltage sensing domain (VSD), possibly acting as a sliding crank that converts the planar rotational movement of the CNBD into a rotational upward displacement of the VSD. This mode of operation and its impact on channel gating are confirmed by computational and experimental data showing that disruption of critical contacts between the three domains affects cAMP- and voltage-dependent gating in three HCN isoforms.
MD Source Data for "Subunit-specific conductance of single HCN pacemaker channels at femtosiemens resolution"
<p>This dataset is the MD source data for the research paper ''Subunit-specific conductance of single HCN pacemaker channels at femtosiemens resolution''. It includes the following parts:</p> <ol> <li>Figures.zip. This file provides high resolution MD related figures, including main figures and supplementary figures.</li> <li>Figure_source_data.zip. This is the source data for the figures in the paper.</li> <li>Homology_Modelling_result.zip. This file provides the input (rHCN4, PDB ID: 7NP3) and output files (mHCN1-4, hHCN4) of homology modelling.</li> <li>MD_input.zip. This is the MD setup input data. It includes starting structure, topology file, .mdp file and force field file. Due to the limitation of storage space (50 GB), it is a pity we couldn't upload all trajectories files (~180 GB). But these files are enough for rerunning the MD simulations.</li> <li>Movie 1. K+ permeation in mHCN2 channel during a 250 ns trajectory.</li> </ol>
The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels
Open the record for dataset details and reuse information.
The upregulation of K+ and HCN channels in developing spiral ganglion neurons is mediated by cochlear inner hair cells
GEO Series GSE242669. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
scRNA-seq analysis (drop-seq) of pharmacological HCN channel block with ZD7288 on rat primary cortical neuronal stem cells
GEO Series GSE181979. Rattus norvegicus. 2 samples. Type: Expression profiling by high throughput sequencing.
scRNA-seq analysis of pharmacological HCN channel block with ZD7288 on rat primary cortical neuronal stem cells
GEO Series GSE181980. Rattus norvegicus. 3 samples. Type: Expression profiling by high throughput sequencing.
scRNA-seq analysis (well-based) of pharmacological HCN channel block with ZD7288 on rat primary cortical neuronal stem cells
GEO Series GSE181972. Rattus norvegicus. 1 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.