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90 results for “HIF-1α”
Data from: IFN-γ-independent control of M. tuberculosis requires CD4 T cell-derived GM-CSF and activation of HIF-1α
<p><strong>RNA sequencing dataset from "Van Dis et al., IFN-γ-independent control of M. tuberculosis requires CD4 T cell-derived GM-CSF and activation of HIF-1α. 2022"</strong></p> <p>The prevailing model of protective immunity to tuberculosis is that CD4 T cells produce the cytokine IFN-γ to activate bactericidal mechanisms in infected macrophages. Although IFN-γ-independent CD4 T cell based control of <em>M. tuberculosis</em> infection has been demonstrated <em>in vivo</em> it is unclear whether CD4 T cells are capable of directly activating macrophages to control infection in the absence of IFN-γ. We developed a co-culture model using CD4 T cells isolated from the lungs of infected mice and <em>M. tuberculosis</em>-infected murine bone marrow-derived macrophages (BMDMs) to investigate mechanisms of CD4 dependent control of infection. This dataset represents RNA sequencing data from M. tuberculosis-infected wild-type and <em>Ifngr-/- </em>murine bone marrow-derived macrophages (BMDMs) after 24 hours of lung CD4 T cell co-culture.</p> <p>CD4 T cells induced differential regulation of 1825 genes in wild-type BMDMs and 1142 genes in <em>Ifngr-/-</em> BMDMs compared to untreated. Although wild-type and <em>Ifngr-/-</em> BMDMs infected with <em>M. tuberculosis</em> were transcriptionally very similar prior to activation, the transcriptome of these genotypes of macrophages diverged after CD4 T cell co-culture. This is likely due in part to the presence or absence of IFN-γ signaling as IFN-γ alone regulates the expression of >2500 genes during <em>M. tuberculosis</em> infection. Still, 769 genes were altered in an IFN-γ-independent manner, with >2-fold upregulation in both wild-type and <em>Ifngr-/- </em>BMDMs. We found no difference in macrophage polarization between untreated M. tuberculosis-infected wild-type and <em>Ifngr-/-</em> BMDMs, and no significant increase in the expression of genes associated with M2 macrophages after CD4 T cell co-culture in either genotype. However, there was significant upregulation of genes associated with M1 macrophages after CD4 T cell co-culture in both genotypes, with wild-type BMDMs slightly more polarized. Collectively, these results show comparable patterns of activation in wild-type and <em>Ifngr-/-</em> macrophage during CD4 T cell co-culture, indicating that CD4 T cells elicit significant polarizing, inflammatory and antimicrobial effects in <em>M. tuberculosis</em>-infected macrophages irrespective of IFN-γ signaling.</p>
Analysis of HIF-1α, MDA, and GPX4 in Peri-Implant Crevicular Fluid
ClinicalTrials.gov study NCT06863116. IPD Sharing: UNDECIDED. Countries: 1. Publications: 6.
YY1 enhances HIF-1α stability in tumor-associated macrophages to suppress anti-tumor immunity of prostate cancer
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Data from: IFN-γ-independent control of M. tuberculosis requires CD4 T cell-derived GM-CSF and activation of HIF-1α
Open the record for dataset details and reuse information.
code and datasets for "GP73 reinforces cytotoxic T-cell function by regulating HIF-1α and increasing antitumor efficacy"
<p>We utilized T-cell-specific GP73 knockout mice to establish MC38 and B16 tumor models to investigate the impact of GP73-deficient T cells on tumor growth. Single-cell sequencing was subsequently employed to classify tumor-infiltrating immune cells and assess changes in cytokines and metabolic genes. Through RNA sequencing, real-time quantitative PCR, western blotting, flow cytometry, seahorse analysis, glucose uptake, and lactate secretion assays, we explored how GP73 regulates HIF-1α to influence T-cell antitumor functionality. Furthermore, we established adoptive transfer experiments to study the ability of GP73-overexpressing T cells to combat tumors. Clinical tumor patient blood samples were collected to assess the relationship between immunotherapy efficacy and T-cell GP73 levels.</p>
Low Level Laser Therapy and Expression of VEGF, NO, VEGFR-2, HIF-1α in Diabetic Foot Ulcers
ClinicalTrials.gov study NCT02452086. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Supplementary material 1 from: Shi L, Jiang M, Li M, Shang X, Li X, Huang M, Wu Y, Qiao C, Wang X, Tian X, Shi Y, Wang Z (2021) Regulation of HIF-1α and p53 in stress responses in the subterranean rodents Lasiopodomys mandarinus and Lasiopodomys brandtii (Rodentia: Cricetidae). Zoologia 38: 1-11. https://doi.org/10.3897/zoologia.38.e58607
Figure S1.
Role of Hypoxic Secretome from Mesenchymal Stem Cells in Enhancing Tissue Repair: Regulatory Effects on HIF-1α, VEGF, and Fibroblast in a Sphincterotomy Rat Model
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Remote Ischemic Postconditioning Increases HIF-1α Plasma Levels and Improves Cardiac Markers After Cardiac Surgery
ClinicalTrials.gov study NCT04284592. IPD Sharing: NO. Countries: 0. Publications: 8.
Determination of Salivary Soluble Urokinase Plasminogen Activator Receptor (SuPAR), Hypoxia-inducible Factor-1 Alpha (HIF-1α), E-cadherin, Galectin 3, IL-4, IL-10 and TNF-α Levels in Individuals With
ClinicalTrials.gov study NCT06430450. IPD Sharing: NO. Countries: 0. Publications: 1.
ID2 and HIF-1α Collaborate to Protect Quiescent Hematopoietic Stem Cells from Activation, Differentiation and Exhaustion
GEO Series GSE198599. Mus musculus; Mus. 6 samples. Type: Expression profiling by high throughput sequencing.
Metabolic dysfunction mediated by HIF-1α contributes to epithelial differentiation defects in eosinophilic esophagitis. [DMOG-ALI]
GEO Series GSE261361. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Activating injury-responsive genes with hypoxia enhances axon regeneration through neuronal HIF-1α
GEO Series GSE73415. Mus musculus. 16 samples. Type: Expression profiling by array.
Conditional Ror1 knockout reveals crucial involvement in lung adenocarcinoma development and identifies novel HIF-1α regulator
GEO Series GSE161182. Mus musculus. 6 samples. Type: Expression profiling by array.
Enhancement of melanoma aggressiveness via p38-MAPK, HIF-1α pathways, and metabolic reprogramming induced by Candida albicans
GEO Series GSE285124. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Differential but complementary roles of HIF-1α and HIF-2α in the regulation of bone homeostasis
GEO Series GSE271730. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Inherent DNA binding specificities of the HIF-1α and HIF-2α transcription factors in chromatin (ChIP-seq)
GEO Series GSE120885. Homo sapiens. 66 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
A HIF-1α/Wnt signaling-dependent control of gene transcription regulates neuronal differentiation of glioblastoma stem cells
GEO Series GSE113512. Homo sapiens. 8 samples. Type: Expression profiling by array.
RPL6 interacts with HMGCS1 to stabilize HIF-1α by activating cholesterol biosynthesis in hepatocellular carcinoma
GEO Series GSE274574. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
MDM2 induces pro-inflammatory and glycolytic responses in M1 macrophages by integrating iNOS-nitric oxide and HIF-1α pathways in mice
GEO Series GSE276736. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.