Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
7,350
datasets available to search
ShareScore release 0.9.0
Dataset results
7,350 results for “HIV”
HOSENG trial – HOme-based oral SElf-testiNG for absent and refusing individuals during a door-to-door HIV testing campaign: a cluster randomised clinical trial in rural Lesotho
<p>These are pseudo-anonymised data from the HOSENG randomized trial: " HOSENG trial – HOme-based oral SElf-testiNG for absent and refusing individuals during a door-to-door HIV testing campaign: a cluster randomised clinical trial in rural Lesotho". The data dictionary explains the data available in the dataset. Between July 2018 and December 2018, 10516 eligible individuals from 106 consenting villages were enrolled from two districts of Lesotho, and followed up for a maximum of 120 days. Main manuscript reference, DOI: <a href="https://doi.org/10.1016/s2352-3018(20)30233-2">10.1016/S2352-3018(20)30233-2. </a>The protocol was published, DOI:10.1186/s13063-019-3469-2.</p>
Data set of the manuscript titled: Follicular Immune Landscaping Reveals a distinct profile of FOXP3hi CD4+ T cells in Treated compared to Untreated HIV
<p>Multiplex imaging data were collected using a scanning confocal system (STELARIS, Leica) and proccessed with the Imaris and Fiji imaging programs. csv files incuding the position identifiers and intensities for each fluorochrome used were generated and data were further analysed using the FlowJo10 program. Neighboring analysis was performed using the G function and mean of minimum distances of relevant cell type pairs. </p>
DRM-labeled HIV-1 protease sequence dataset
<p>An HIV-1 protease dataset with labeled DRMs derived from the Stanford HIV Drug Resistance Database<sup>1,2</sup> is provided. It is in <em>fasta</em> format with major protease drug resistance mutations (as defined by Wensing et al.<sup>3</sup>) provided in the sequence name section (following the ">" symbol) as a comma-separated list. The dataset was used in the following paper: "Ahmed A., de Souza D. R., Link R. W., Nonnemacher M. R., Wigdahl B., Dampier W. Design of a SHERLOCK-based low resource screening assay for HIV-1 drug resistance, in preparation, 2021. "</p>
Dataset of 'HIV infection is associated with compromised tumor microenvironment adaptive immune reactivity in Hodgkin Lymphoma'
<p><span><span>§<span> </span></span></span><strong><span>:</span></strong><span>The data were generated using the i) GeoMx Digital Spatial Profiler (DSP) platform developed by Nanostring Technologies. GeoMx analysis utilizes <em>in situ </em>RNA hybridization with Whole Atlas Transcriptome probe (Nanostring) and ii) HTG platform (Immune Response kit) Our dataset comprises samples from donors categorized as HLposHIVnegEBVneg, HLposHIVposEBVpos, or HLposHIVnegEBVpos (HL: Hodgkin Lymphoma). Regions of interest (ROI) were spatially profiled to capture distinct molecular signatures associated with these donor categories.</span></p>
Phylogenetic and epidemiologic data relating to age-specific HIV incidence and transmission in Rakai, Uganda, 2003-2018.
<p>This repository contains the data for the analyses presented in the paper Growing gender inequity in HIV infection in Africa: sources and policy implications by M. Monod, A. Brizzi, R. Galiwango, R. Ssekubugu, Y. Chen, X. Xi et al. available in the pre-print <a href="https://doi.org/10.1101/2023.03.16.23287351">https://doi.org/10.1101/2023.03.16.23287351</a> </p> <p>We thank all contributors, program staff and participants to the Rakai Community Cohort Study; all members of the PANGEA-HIV consortium, the <a href="https://www.rhsp.org/index.php">Rakai Health Sciences Program</a>, and CDC Uganda for comments on an earlier version of the manuscript.</p> <p>We also extend our gratitude to the <a href="https://doi.org/10.14469/hpc/2232">Imperial College Research Computing Service</a> and the <a href="https://www.bdi.ox.ac.uk/about/biomedical-research-computing">Biomedical Research Computing Cluster</a> at the University of Oxford for providing the computational resources to perform this study. Additionally, we thank the Office of Cyberinfrastructure and Computational Biology at the <a href="https://www.niaid.nih.gov/">National Institute for Allergy and Infectious Diseases</a> for data management support; and Zulip for sponsoring team communications through the Zulip Cloud Standard chat app. </p> <p>All analysis code is available from <a href="https://github.com/MLGlobalHealth/phyloSI-RakaiAgeGender">https://github.com/MLGlobalHealth/phyloSI-RakaiAgeGender</a>.</p>
Mixed methods systematic review and metasummary about barriers and facilitators for the implementation of cotrimoxazole and isoniazid - preventive therapies for people living with HIV.
<p>This is the minimal data set underlying the findings of our systematic review and metasummary:</p> <p>We uploaded the following data extracted from the studies included in our review:</p> <p>- Systematic Review protocol, also published in PROSPERO (CRD42019137778).</p> <p>- detailed description of studies included in our review.</p> <p>- barriers identified in the review (metasummary).</p> <p>- facilitators identified in the review.</p>
Minimal dataset for "Insights to HIV-1 coreceptor usage by estimating HLA adaptation with Bayesian generalized linear mixed models"
<p>This repository contains a minimal data set to reproduce all results that don't compromise the privacy concerns for the manuscript "Insights to HIV-1 coreceptor usage by estimating HLA adaptation with Bayesian generalized linear mixed models".<br> <br> The repository contains the following data:</p> <ul> <li>adaptscore_acute.csv <ul> <li>A csv file that contains the estimated adaptation scores for the acute data set with HLA I model.</li> </ul> </li> <li>adaptscore_leftout.csv <ul> <li>A csv file that contains the estimated adaptation scores for the leftout data set with the joint HLA I and HLA II model</li> </ul> </li> <li>adaptscore_training.csv <ul> <li>A csv file that contains the estimated adaptation scores for the traininig data set with the joint HLA I and HLA II model</li> </ul> </li> <li>adaptscore_training_hla1_without_clin.csv <ul> <li>A csv file that contains the estimated adaptation scores for the training data set with the HLA I model (via cross-validation)</li> </ul> </li> <li>adaptscore_training_seed2.csv <ul> <li>A csv file that contains the estimated adaptation scores for the training data set with the joint HLA I and HLA II model via cross-validation with another seed</li> </ul> </li> </ul>
Population size, HIV prevalence, and antiretroviral therapy coverage among key populations in sub-Saharan Africa: collation and synthesis of survey data 2010-2023
<p>This dataset contains surveillance study estimates for population size, HIV prevalence, and ART coverage among female sex workers (FSW), men who have sex with men (MSM), people who inject drugs (PWID), and transgender men and women (TGM/W) from 2010-2023. It was created to support the UNAIDS Estimates Key Population Workbook for use by HIV estimates teams in sub-Saharan Africa. Key population surveillance reports, including Ministry of Health-led biobehavioural surveys, mapping studies, and academic studies were used to populate the database.</p> <p>The dataset was populated using existing key population size estimate databases including:</p> <ul> <li>UNAIDS Key Population Atlas</li> <li>US Centers for Disease Control and Prevention surveillance database</li> <li>Global Fund against HIV/AIDS, TB, and Malaria surveillance database</li> <li>Global.HIV database</li> <li>Systematic review databases among MSM (<a href="https://pubmed.ncbi.nlm.nih.gov/31601542/" target="_blank" rel="noopener">Stannah et al, 2019</a> and <a href="https://pubmed.ncbi.nlm.nih.gov/37453439/" target="_blank" rel="noopener">Stannah et al., 2023</a>) and PWID (<a href="https://pubmed.ncbi.nlm.nih.gov/36996857/" target="_blank" rel="noopener">Degenhardt et al., 2023</a>)</li> </ul> <p><br>and was additionally supplemented by a literature review of peer-reviewed and grey literature sources.</p> <p>The data can be <a href="https://shiny.dide.ic.ac.uk/kp-data/" target="_blank" rel="noopener">explored in this web application</a> and the <a href="https://www.medrxiv.org/content/10.1101/2022.07.27.22278071v3" target="_blank" rel="noopener">accompanying manuscript can be found here</a></p>
Dataset of "Single-Cell RNA-Seq Reveals Transcriptional Heterogeneity in Latent and Reactivated HIV-infected Cells"
<p><strong>Detailed quantitative analysis of GFP expression in SAHA and TCR-treated cells & Computational analysis of bulk and single-cell RNA-Seq data.</strong></p> <p> </p> <p><em><strong>Detailed quantitative analysis of GFP expression in SAHA and TCR-treated cells.</strong></em></p> <p>Cells were prepared for single cell analysis at the Genome Technology Facility (GTF) of the University of Lausanne. Cells were loaded on Fluidigm C1 IFC plates (5-10 μm), with run ID smart33, smart34 and smart35, corresponding to untreated, SAHA- and TCR-treated conditions respectively. After single cell capture on the Fluidigm C1 IFC plate, each chamber was inspected visually by microscopy and pictures were captured with a Zeiss Axiovert 200 M fluorescence microscope equipped with a Roper Scientific CoolSnap HQ camera using a Plan-Neofluar 10X lens (smart34 run) or 20X lens (for smart35 run). For each capture chamber, pictures in bright field and FITC channel were taken with the MetaMorph 6.3 software. Picture analysis was then performed using ImageJ 1.50b software (open access software: website). Brightness and contrast were adjusted for qualitative assessment of the pictures.</p> <p><em><strong>Computational analysis of bulk and single-cell RNA-Seq data.</strong></em></p> <p>Upon bulk or single cell isolation, RNA extraction and library preparation was performed according to Illumina protocols. Bulk and single-cell RNA-Seq data analysis are detailed here.</p> <p> </p> <p>Linked to the paper published in Cell Reports (doi:10.1016/j.celrep.2018.03.102): </p> <p><strong>Single-Cell RNA-Seq Reveals Transcriptional Heterogeneity in Latent and Reactivated HIV-infected Cells</strong></p> <p>Despite effective treatment, HIV can persist in latent reservoirs, which represent a major obstacle towards HIV eradication. Targeting and reactivating latent cells is challenging due to the heterogeneous nature of HIV infected cells. Here, we used a primary model of HIV latency and single-cell RNA sequencing to characterize transcriptional heterogeneity during HIV latency and reactivation. Our analysis identified transcriptional programs leading to successful reactivation of HIV expression.</p> <p> </p> <p> </p>
Sample data for analysis of sequence variation in HIV
<p>These are downsampled interleaved paired fastq datasets from Jair et. 2019 (<a href="https://doi.org/10.1371/journal.pone.0214820">https://doi.org/10.1371/journal.pone.0214820</a>). The datasets were prepared by:</p> <ol> <li>Downloading original data from NCBI SRA (https://www.ncbi.nlm.nih.gov/bioproject/PRJNA517147)</li> <li>Trimming contaminating Nextera adapters using trim-galore</li> <li>Mapping reads against nxb2 reference of HIV genome (K03455.1) with BWA MEM</li> <li>Restricting mapped reads to <em>pol</em> gene vicinity (K03455.1:2000-5100)</li> <li>Downsampling mapped data to ~10% of the original with Picard's DownsampleSam</li> <li>Converting BAM to Interleaved Fastq with Picard's SamToFastq</li> <li>Gzipping resultant interleaved paired fastq files</li> </ol>
X-ray structures of HIV-1 protease
<p>As of March 1, 2023, there were 233 X-ray structures of HIV-1 protease available in the RCSB PDB database (<a href="https://www.rcsb.org/">https://www.rcsb.org/</a>). Out of these structures, 219 had ligands bound in the active site while 14 did not have any ligands. To prepare the structures for analysis, we removed water, ions, and solvent molecules, extracted the ligands from the receptors, and aligned all the structures. Each HIV-1 protease structure is identified by its PDB ID (<pdbid>.pdb) while the corresponding ligand structures are named as ligs_<pdbdid>.pdb.</p>
Dataset: Knowledge, information needs and behavior regarding HIV and sexually transmitted infections among migrants from sub-Saharan Africa living in Germany: Results of a participatory health research survey.
<p>Dataset for: Koschollek C, Kuehne A, Müllerschön J, Amoah S, Batemona-Abeke H, Dela Bursi T, Mayamba P, Thorlie A, Mputu Tshibadi C, Wangare Greiner V, Bremer V, Santos-Hövener C: Knowledge, information needs and behavior regarding HIV and sexually transmitted infections among migrants from sub-Saharan Africa living in Germany: Results of a participatory health research survey.</p> <p>This dataset has been described in a PLoS One paper and contains all data necessary to replicate the results presented within this paper (10.1371/journal.pone.0227178). Please cite both the paper as well as the DOI of this dataset if you make use of the data.</p>
Molecular dynamics trajectories for SARS-CoV-2 Mpro with 7 HIV inhibitors
<p>Raw trajectory data (GROMACS format) of all atom molecular dynamics simulation of COVID-19 related SARS-CoV-2 dimeric main protease (based on PDB 6LU7) with 7 kinds of HIV inhibitors (darunavir, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir, and tipranavir) were calculated on massively parallel supercomputer HOKUSAI Big Waterfall at RIKEN ISC, and a special-purpose computer, MDGRAPE-4A, at RIKEN BDR, JAPAN. For each ligand, 200ns length 28 trajectories were calculated. Some of these trajectories were calculated further longer. We can observe formation of encounter complex and investigate potential binding sites on the surface of the dimeric protease. We hope that these raw data are valuable for further drug repurposing/development research targeting the SARS-CoV-2 main protease. We will submit analysis of these data to refereed journal.</p> <p>Molecular dynamics simulations were performed under NVT at 310K, with the time step 2.5fs. The starting structure was prepared based on PDB 6LU7, with amber14sb force field in about 10nm cubic box with periodic boundary conditions. The ligands were initially placed apart from the active sites of the dimeric main protease.</p> <p>We have also already deposited 10 microseconds trajectories of the dimeric protease without ligand (with amber99sb-ildn force field) in the repository https://data.mendeley.com/datasets/vpps4vhryg/1 (DOI:10.17632/vpps4vhryg.1).</p> <p>Files:</p> <ul> <li><strong><em>LIG</em></strong>_28traj200ns_every200ps.zip (28trajectories for each ligand) <ul> <li>traj200ns_every200ps/<strong><em>LIG</em></strong>/<strong><em>a</em></strong>/traj200ns_every200ps_<em><strong>LIG</strong>-<strong>a</strong>-<strong>n</strong></em>.xtc <ul> <li>(trajectory in GROMACS XTC)</li> </ul> </li> <li>traj200ns_every200ps/<strong><em>LIG</em></strong>/<strong><em>a</em></strong>/conf.gro <ul> <li>(initial condition in GROMACS GRO)</li> </ul> </li> <li>traj200ns_every200ps/<em><strong>LIG</strong></em>/topology/ <ul> <li>(contains topology files)</li> </ul> </li> <li>traj200ns_every200ps/<strong><em>LIG</em></strong>/mdp/ <ul> <li>(contains run paramter files)</li> </ul> </li> </ul> </li> <li>ZZZ_20traj1us_every200ps.zip (20trajectories extended to 1microsecond) <ul> <li>traj1us_every200ps/traj1us_every200ps_<em><strong>LIG</strong>-<strong>a</strong>-<strong>n</strong></em>.xtc <ul> <li>DAR-C-06, DAR-D-07</li> <li>IND-C-05, IND-C-06, IND-D-06</li> <li>LOP-A-02, LOP-D-03</li> <li>NEL-B-01, NEL-C-07, NEL-D-02</li> <li>RIT-B-07, RIT-C-07</li> <li>SAQ-B-01, SAQ-C-04, SAQ-D-03</li> <li>TPR-A-07, TPR-B-04, TPR-B-06, TPR-C-05, TPR-D-02</li> </ul> </li> </ul> </li> <li>ZZZ_3traj6us_every1ns.zip (3trajectories extended to 6microseconds or more) <ul> <li>traj6us_every1ns/traj6us_every1ns_<em><strong>LIG</strong>-<strong>a</strong>-<strong>n</strong></em>.xtc <ul> <li>IND-D-06, NEL-B-01, TPR-B-04</li> </ul> </li> </ul> </li> </ul> <p> </p> <ul> <li>ZZZ_LigandBindingPosePDBs.zip (pickup 3 snapshots for each ligand) <ul> <li>LigandBindingPosePDBs/<em><strong>LIG</strong>-<strong>a</strong>-<strong>n</strong></em>_frame.pdb</li> </ul> </li> </ul> <p> </p> <ul> <li>movies_overlooking_28traj200ns.zip (7x2movies) <ul> <li>movies_28traj200ns/movie_overlooking_<strong><em>LIG</em></strong>_28traj200ns-viewA.mp4 <ul> <li>inspecting 28traj at once</li> </ul> </li> <li>movies_28traj200ns/movie_overlooking_<strong><em>LIG</em></strong>_28traj200ns-viewB.mp4 <ul> <li>from the opposite angle</li> </ul> </li> </ul> </li> <li>movies_1us.zip (17movies) <ul> <li>movies_1us/movie_<em><strong>LIG</strong>-<strong>a</strong>-<strong>n</strong></em>_1us.mp4</li> </ul> </li> <li>movies_6us.zip (3movies) <ul> <li>movies_6us/movie_<em><strong>LIG</strong>-<strong>a</strong>-<strong>n</strong></em>_6us.mp4</li> </ul> </li> </ul> <p> where</p> <p> <em><strong>LIG</strong></em>={DAR,IND,LOP,NEL,RIT,SAQ,TPR}<br> DAR:darunavir<br> IND:indinavir<br> NEL:nelfinavir<br> RIT:ritonavir<br> SAQ:saquinavir<br> TPR:tipranavir<br> <em><strong>a</strong></em>={A,B,C,D}<br> <em><strong>n</strong></em>={01,02,03,04,05,06,07}</p> <p> </p> <ul> <li>ZZZz_3traj1us_every200ps_unbinding.zip (3trajectories extended to 1microsecond exhibiting unbinding)</li> <li>ZZZz_56traj200ns_every200ps_negative_control.zip (56trajectories as a negative control)</li> <li>ZZZz_LigandBindingPosePDBsRevised.zip (pickuped 3 snapshots for each ligand)</li> </ul> <p> </p>
Data and analysis scripts associated with the paper 'Long-term experimental evolution of HIV-1 reveals effects of environment and mutational history''
<p><em>Eva Bons, Christine Leemann, Karin J. Metzner, Roland R. Regoes</em></p> <p>This repository contains all the data and analysis scripts associated with the paper 'Long-term experimental evolution of HIV-1 reveals effects of environment and mutational history'</p> <p>See the readme after unpacking the .zip for a description of the files</p>
Sex and Age Impact CD4+ T Cell Susceptibility to HIV In Vitro Through Cell Activation Dynamics
<p>Cellular composition and the responsiveness of the immune system evolve upon aging and are influenced by biological sex. CD4+ T cells from women living with HIV exhibit a decreased viral replication ex vivo compared to men's. We, thus, hypothesized that these findings could be recapitulated in vitro and infected primary CD4+ T cells with HIV-based vectors pseudotyped with VSV-G or HIV envelopes. We used cells isolated from twenty donors to interrogate the effect of sex and age on permissiveness over a six-day activation kinetics. Our data identified an increased permissiveness to HIV between 24 and 72 h post-stimulation. Sex- and age-based analyses at these time points showed an increased susceptibility to HIV of the cells isolated from males and from donors over 50 years of age, respectively. A parallel assessment of surface markers' expression revealed higher frequencies of activation marker CD69 and of immune checkpoint inhibitors (PD-1 and CTLA-4) in the cells from highly permissive donors. Furthermore, positive correlations were identified between the expression kinetics of CD69, PD-1 and CTLA-4 and HIV expression kinetics. The cell population heterogeneity was assessed using a single-cell RNA-Seq analysis and no cell subtype enrichment was identified according to sex. Finally, transcriptomic analyses further highlighted the role of activation in those differences with enriched activation and cell cycle gene sets in male and older female cells. Altogether, this study brought further evidence about the individual features affecting HIV replication at the cellular level and should be considered in latency reactivation studies for an HIV cure.</p>
Optimized SMRT-UMI protocol produces highly accurate sequence datasets from diverse populations – application to HIV-1 quasispecies
<p>Pathogen diversity resulting in quasispecies can enable persistence and adaptation to host defenses and therapies. However, accurate quasispecies characterization can be impeded by errors introduced during sample handling and sequencing which can require extensive optimizations to overcome. We present complete laboratory and bioinformatics workflows to overcome many of these hurdles. The Pacific Biosciences single molecule real-time platform was used to sequence PCR amplicons derived from cDNA templates tagged with universal molecular identifiers (SMRT-UMI). Optimized laboratory protocols were developed through extensive testing of different sample preparation conditions to minimize between-template recombination during PCR and the use of UMI allowed accurate template quantitation as well as removal of point mutations introduced during PCR and sequencing to produce a highly accurate consensus sequence from each template. Handling of the large datasets produced from SMRT-UMI sequencing was facilitated by a novel bioinformatic pipeline, Probabilistic Offspring Resolver for Primer IDs (PORPIDpipeline), that automatically filters and parses reads by sample, identifies and discards reads with UMIs likely created from PCR and sequencing errors, generates consensus sequences, checks for contamination within the dataset, and removes any sequence with evidence of PCR recombination or early cycle PCR errors, resulting in highly accurate sequence datasets. The optimized SMRT-UMI sequencing method presented here represents a highly adaptable and established starting point for accurate sequencing of diverse pathogens. These methods are illustrated through characterization of human immunodeficiency virus (HIV) quasispecies.</p>
Data from: The impact of long-term azithromycin on antibiotic resistance in HIV-associated chronic lung disease
<p><b>Background</b>: Selection for resistance to azithromycin (AZM) and other antibiotics such as tetracyclines and lincosamides remains a concern with long-term AZM use for treatment of chronic lung diseases (CLD). We investigated the impact of 48 weeks of AZM on the carriage and antibiotic resistance of common respiratory bacteria among children with HIV-associated CLD.</p> <p><b>Methods</b>: Nasopharyngeal (NP) swabs and sputa were collected at baseline, 48 and 72 weeks from participants with HIV-associated CLD randomised to receive weekly AZM or placebo for 48 weeks and followed post-intervention until 72 weeks. The primary outcomes were prevalence and antibiotic resistance of <i>Streptococcus pneumoniae</i> (SP), <i>Staphylococcus aureus </i>(SA), <i>Haemophilus influenzae </i>(HI), and <i>Moraxella catarrhalis </i>(MC) at these timepoints. Mixed-effects logistic regression and Fisher's exact test were used to compare carriage and resistance respectively.</p> <p><b>Results</b>: Of 347 (174 AZM, 173 placebo) participants (median age 15 years [IQR =13–18], females 49%),NP carriage was significantly lower in the AZM (n=159) compared to placebo (n=153) arm for SP (18% vs 41%, <i>p</i><0.001)<i>, </i>HI (7% vs 16%, p=0.01)<i>, </i>and MC (4% vs 11%, <i>p</i>=0.02); SP resistance to AZM (62% [18/29] vs 13%[8/63], <i>p</i><0.0001) or tetracycline (60%[18/29] vs 21%[13/63], <i>p</i><0.0001) were higher in the AZM arm. Carriage of SA resistant to AZM (91% [31/34] vs 3% [1/31],<i> p</i><0.0001), tetracycline (35% [12/34] vs 13% [4/31],<i> p</i>= 0.05) and clindamycin (79% [27/34] vs 3% [1/31],<i> p</i><0.0001) was also significantly higher in the AZM arm and persisted at 72 weeks. Similar findings were observed for sputa.</p> <p><b>Conclusions</b>: The persistence of antibiotic resistance and its clinical relevance for future infectious episodes requiring treatment needs further investigation.</p>
Data for the "Discovery of Dehydroamino Acid Residues in the Capsid and Matrix Structural Proteins of HIV-1"
<p>Bottom-up mass spectrometry-based proteomic analysis (trypsin) was performed on four biological replicates of HIV-1 virions. These virions were isolated from HEK293T cells transfected with a HIV-1 proviral plasmid derived from the pNL4-3 molecular clone, rendered biosafe due to inactivating point mutations in both the env and vpr reading frames. There are 8 total spectra, 4 are from unlabeled aliquots of sample, and 4 are from aliquots of sample treated with glutathione to label dehydroamino acids (Spectra can be accessed on MassIVE (MSV000088220). All data was analyzed using MetaMorpheus version 0.0.319 (https://github.com/smith-chem-wisc/MetaMorpheus). Provided here are the results of this analysis.</p>
RNAseq sequences of the study "Transactive response DNA-binding Protein (TARDBP/TDP-43) regulates early HIV-1 entry and infection" (1/2)
<p>Each pair of FASTQ files corresponds to a specific sample condition:</p> <table> <thead> <tr> <th scope="col">Condition</th> <th scope="col">Sample</th> <th scope="col">FASTQ name R1</th> <th scope="col">FASTQ name R2</th> </tr> </thead> <tbody> <tr> <td>Cneg</td> <td>RNASEQ-AVF1</td> <td>RNASEQ-AVF1_S1_R1_001.fastq.gz</td> <td>RNASEQ-AVF1_S1_R2_001.fastq.gz</td> </tr> <tr> <td>Flag-wt-TDP-43</td> <td>RNASEQ-AVF2</td> <td>RNASEQ-AVF2_S2_R1_001.fastq.gz</td> <td>RNASEQ-AVF2_S2_R2_001.fastq.gz</td> </tr> <tr> <td>Flag-NLS-mut-TDP-43</td> <td>RNASEQ-AVF3</td> <td>RNASEQ-AVF3_S3_R1_001.fastq.gz</td> <td>RNASEQ-AVF3_S3_R2_001.fastq.gz</td> </tr> <tr> <td>Cneg</td> <td>RNASEQ-AVF4</td> <td>RNASEQ-AVF4_S4_R1_001.fastq.gz</td> <td>RNASEQ-AVF4_S4_R2_001.fastq.gz</td> </tr> <tr> <td>Scramble</td> <td>RNASEQ-AVF5</td> <td>RNASEQ-AVF5_S5_R1_001.fastq.gz</td> <td>RNASEQ-AVF5_S5_R2_001.fastq.gz</td> </tr> <tr> <td>TDP-43 siRNA A</td> <td>RNASEQ-AVF6</td> <td>RNASEQ-AVF6_S6_R1_001.fastq.gz</td> <td>RNASEQ-AVF6_S6_R2_001.fastq.gz</td> </tr> <tr> <td>TDP-43 siRNA B</td> <td>RNASEQ-AVF7</td> <td>RNASEQ-AVF7_S7_R1_001.fastq.gz</td> <td>RNASEQ-AVF7_S7_R2_001.fastq.gz</td> </tr> <tr> <td>TDP-43 siRNA C</td> <td>RNASEQ-AVF8</td> <td>RNASEQ-AVF8_S8_R1_001.fastq.gz</td> <td>RNASEQ-AVF8_S8_R2_001.fastq.gz</td> </tr> </tbody> </table> <p> </p>
RNAseq sequences of the study "Transactive response DNA-binding Protein (TARDBP/TDP-43) regulates early HIV-1 entry and infection" (2/2)
<p>Each pair of FASTQ files corresponds to a specific sample condition:</p> <table> <thead> <tr> <th scope="col">Condition</th> <th scope="col">Sample</th> <th scope="col">FASTQ name R1</th> <th scope="col">FASTQ name R2</th> </tr> </thead> <tbody> <tr> <td>TDP-43 siRNA D</td> <td>RNASEQ-AVF9</td> <td>RNASEQ-AVF9_S1_R1_001.fastq.gz</td> <td>RNASEQ-AVF9_S1_R2_001.fastq.gz</td> </tr> <tr> <td>Cneg</td> <td>RNASEQ-AVF10</td> <td>RNASEQ-AVF10_S2_R1_001.fastq.gz</td> <td>RNASEQ-AVF10_S2_R2_001.fastq.gz</td> </tr> <tr> <td>Flag-wt-TDP-43</td> <td>RNASEQ-AVF11</td> <td>RNASEQ-AVF11_S3_R1_001.fastq.gz</td> <td>RNASEQ-AVF11_S3_R2_001.fastq.gz</td> </tr> <tr> <td>Flag-NLS-mut-TDP-43</td> <td>RNASEQ-AVF12</td> <td>RNASEQ-AVF12_S4_R1_001.fastq.gz</td> <td>RNASEQ-AVF12_S4_R2_001.fastq.gz</td> </tr> <tr> <td>Cneg</td> <td>RNASEQ-AVF13</td> <td>RNASEQ-AVF13_S5_R1_001.fastq.gz</td> <td>RNASEQ-AVF13_S5_R2_001.fastq.gz</td> </tr> <tr> <td>Scramble</td> <td>RNASEQ-AVF14</td> <td>RNASEQ-AVF14_S6_R1_001.fastq.gz</td> <td>RNASEQ-AVF14_S6_R2_001.fastq.gz</td> </tr> <tr> <td>Oligos B+C</td> <td>RNASEQ-AVF15</td> <td>RNASEQ-AVF15_S7_R1_001.fastq.gz</td> <td>RNASEQ-AVF15_S7_R2_001.fastq.gz</td> </tr> <tr> <td>Oligos A+B+C</td> <td>RNASEQ-AVF16</td> <td>RNASEQ-AVF16_S8_R1_001.fastq.gz</td> <td>RNASEQ-AVF16_S8_R2_001.fastq.gz</td> </tr> </tbody> </table> <p> </p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.