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76 results for “HIV Services”
Enhancing Partner Services Among Men Who Have Sex With Men Living With HIV
ClinicalTrials.gov study NCT04971967. IPD Sharing: YES. Countries: 1. Publications: 1.
Modeling to determine when to re-open HIV services during COVID-19 pandemic
<p><b>The Risks and Benefits of Providing HIV Services during the COVID-19 Pandemic</b></p> <p><b>Introduction</b></p> <p>The COVID-19 pandemic has caused widespread disruptions including to health services. In the early response to the pandemic many countries restricted population movements and some health services were suspended or limited. In late 2020 and early 2021 some countries re-imposed restrictions. Health authorities need to balance the potential harms of additional SARS-CoV-2 transmission due to contacts associated with health services against the benefits of those services, including fewer new HIV infections and deaths. This paper examines these trade-offs for select HIV services. </p> <p><b>Methods</b></p> <p>We used four HIV simulation models (Goals, HIV Synthesis, Optima HIV and EMOD) to estimate the benefits of continuing HIV services in terms of fewer new HIV infections and deaths. We used three COVID-19 transmission models (Covasim, Cooper/Smith and a simple contact model) to estimate the additional deaths due to SARS-CoV-2 transmission among health workers and clients. We examined four HIV services: voluntary medical male circumcision, HIV diagnostic testing, viral load testing and programs to prevent mother-to-child transmission. We compared COVID-19 deaths in 2020 and 2021 with HIV deaths occurring now and over the next 50 years discounted to present value. The models were applied to countries with a range of HIV and COVID-19 epidemics.</p> <p><b>Results</b></p> <p>Maintaining these HIV services could lead to additional COVID-19 deaths of 0.002 to 0.15 per 10,000 clients. HIV-related deaths averted are estimated to be much larger, 19 - 146 discounted deaths per 10,000 clients.</p> <p><b>Discussion</b></p> <p>While there is some additional short-term risk of SARS-CoV-2 transmission associated with providing HIV services, the risk of additional COVID-19 deaths is at least 100 times less than the HIV deaths averted by those services. Ministries of Health need to take into account many factors in deciding when and how to offer essential health services during the COVID-19 pandemic. This work shows that the benefits of continuing key HIV services are far larger than the risks of additional SARS-CoV-2 transmission.</p>
Data set for manuscript "Optimal utilization of PMTCT of HIV services among adolescents under group versus focused antenatal care"
<p>The derived variables in the data set are labeled "DER what variables they are derived from" except the variable "optimal utilization which is a composite outcome of other variables depending on HIV status as described in the manuscript.</p> <p>The variables "...cat" are categorized or recoded from an original numeric/ categorical variable</p> <p>The variables bin are used when a "cat" variable exists but further recoding is done to form a binary variable</p>
Patient preferences for HIV service delivery models: A discrete choice experiment in Kisumu, Kenya
<p><strong>Background</strong>: Novel "differentiated service delivery" models for HIV treatment that reduce clinic visit frequency, minimize waiting time, and deliver treatment in the community promise retention improvement for HIV treatment in Sub-Saharan Africa. Quantitative assessments of differentiated service delivery (DSD) feature most preferred by patient populations do not widely exist but could inform the selection and prioritization of different types of DSD models.</p> <p><strong>Methods</strong>: We used a discrete choice experiment (DCE) to elicit patient preferences for HIV treatment services and how they differ across DSD models. We surveyed adults aged >18 years, enrolled in HIV care for >6 months between February and March 2019 at four facilities in Kisumu County, Kenya. DCE offered patients a series of comparisons between three treatment models, each of which varied in seven attributes: ART refill location, the quantity of ART dispensed at each refill, medication pick-up hours, type of adherence support, clinical visit frequency, staff attitude, and professional cadre of the person providing ART refills. We used a hierarchical Bayesian model to estimate attribute importance and the relative desirability of care characteristics, latent class analysis (LCA) for groups of preferences, and mixed logit model for willingness to trade analysis.</p> <p><strong>Results</strong>: Of 242 patients, 128 (53.8%) were females and 150 (62.8%) lived in rural areas. Patients placed the greatest importance on ART refill location [19.5% (95%CI 18.4, 20.6)] and adherence support [19.5% (95%CI 18.7, 20.3)], followed by staff attitude [16.1% (95%CI 15.1, 17.2)]. In the mixed logit, patients preferred the nice attitude of the staff (coefficient=1.60), refill ART health center (Coeff=1.58), and individual adherence support (Coeff=1.54), 3 or 6 months for ART refill (Coeff=0.95 & 0.80, respectively) and pharmacists (instead of lay health workers) providing ART refill (Coeff=0.64). No differences were observed by gender or urbanicity. LCA revealed two distinct groups (59.5% vs.40.5%).</p> <p><strong>Conclusions</strong>: Participants preferred 3 to 6-month refill intervals or clinic visit spacing, which DSD provides for stable patients. While DSD has also encouraged community ART group options, our results suggest strong patient preferences for ART refills from health centers or by pharmacists over lay caregivers or community members. These preferences held across gender and urban/rural subpopulations. </p>
Risky sexual behaviours and utilization of HIV testing services among the adolescent girls and young women aged between 15-24 years in Kibra Sub County, Nairobi County, Kenya
<p><strong>Introduction: </strong>HIV remains a significant global health challenge, disproportionately affecting adolescent girls and young women (AGYW). HIV testing is crucial in controlling the infection and reducing its prevalence. Understanding risky sexual behaviors among AGYW is pivotal in aligning prevention interventions. Despite global prevention efforts, testing gaps persist among AGYW, linked to risky sexual behavior (RSB). This study explores the association between these behaviors and HIV testing utilization among AGYW (aged 15-24) in Kibra Sub County, Nairobi.</p> <p><strong>Methods: </strong>A cross-sectional study sampled 379 AGYW from three wards in Kibra Sub County in Nairobi County. To be an eligible participant, one must have been a resident for at least one year before the time of the study and aged between 15-24 years, employing standardized structured interviewer-administered questionnaires and statistical analyses. Results were analyzed using Chi-square tests and logistic regression. Data was collected between June to July 2023.</p> <p><strong>Results: </strong>Overall, HIV testing prevalence was 60.7% (n=230). Those aged 20-24 were 71.3% (n=164), with secondary education were 63.5% (n=146) and married 28.7% (66) were more likely to undergo testing. Participants engaging in risky behaviors such as lack of condom use (3.96 times more likely), experiencing gender-based violence (4.65 times more likely), or contracting STIs (2.85 times more likely) had higher odds of seeking HIV testing services.</p> <p><strong>Conclusion: </strong>This study establishes a clear link between risky sexual behaviors and HIV testing among AGYW, with a 60.7% testing prevalence; however, gaps still exist. Efforts to enhance testing rates are vital. Interventions should align with acceptable methods, focusing on this high-risk group to ensure effective HIV care and prevention.</p>
Country uptake of WHO recommendations on differentiated HIV testing services approaches: A global policy review
<p><strong>Objectives </strong></p> <p>In 2015 and 2016, the World Health Organization (WHO) issued guidelines on HIV testing services (HTS) highlighting recommendations for a strategic mix of differentiated HTS approaches. The Policy review examines the uptake of differentiated HIV Testing service (HTS) approaches recommendations.</p> <p><strong>Methods </strong></p> <p>Data were extracted from all available national policies published between January 2015 and June 2019 and stored in WHO's national policy repository. WHO recommended as HTS approaches facility-based testing, community-based testing, HIV self-testing and provider-assisted referral (or assisted partner notification); in terms of testing components: pre-test information, lay provider testing and rapid testing. Descriptive analyses were conducted to examine availability of policies and adherence to WHO-differentiated HTS recommendations.</p> <p><strong>Results</strong></p> <p>Of 194 countries worldwide, 65 published policies were identified in the review period. 24 were from the African region (51% of African countries, 24/47), six from the Eastern Mediterranean region (29%, 6/21), 21 from the European region (40%, 21/53), five from the American region (14%, 5/35), four from the South East Asia region (36%, 4/11) and five from the Western Pacific Region (19%, 5/27). Only five countries were compliant with recommendations and 63 included at least one. 85% (n=55) included facility-based testing for pregnant women, 75% (n=49) facility-based testing for key populations, 74% (n=48) community-based testing for key populations, 38% (n=25) HIV self-testing, 25% (n=16) provider-assisted referral, 69% (n=45) rapid testing, 57% (n=37) post-test counselling, 45% (n=29) lay provider testing and 29% (n=19) pre-test information. The highest uptake of WHO recommendations was seen in countries from the African and Eastern Mediterranean region.</p> <p><strong>Conclusions</strong></p> <p>There was substantial variability in the uptake of WHO HTS recommendations, ranging from 25% to 85%. Uptake was above 50% for facility-based testing for pregnant women and key populations, community-based testing, rapid diagnostic testing and post-test counselling; uptake was between 25% and 45% for all the other recommendations.</p>
Using Social Media to Deliver HIV Self-Testing Kits and Link to Online PrEP Services
ClinicalTrials.gov study NCT04155502. IPD Sharing: YES. Countries: 1. Publications: 2.
Patient Actor Training to Improve HIV Services for Adolescents in Kenya
ClinicalTrials.gov study NCT02928900. IPD Sharing: YES. Countries: 1. Publications: 3.
Integrating Safer Conception Counseling to Transform HIV Family Planning Services
ClinicalTrials.gov study NCT03167879. IPD Sharing: YES. Countries: 1. Publications: 3.
Data from: Health services intervention integrating HTN and HIV care improves long-term blood pressure control among people living with HIV in Uganda
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Patient preferences for HIV service delivery models: A discrete choice experiment in Kisumu, Kenya
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Country uptake of WHO recommendations on differentiated HIV testing services approaches: A global policy review
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Risky sexual behaviours and utilization of HIV testing services among the adolescent girls and young women aged between 15-24 years in Kibra Sub County, Nairobi County, Kenya
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Modeling to determine when to re-open HIV services during COVID-19 pandemic
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Quality of care in a differentiated HIV service delivery intervention in Tanzania: A mixed methods study
<p><b>Background:</b> Differentiated service delivery (DSD) offers benefits to people living with HIV (improved access, peer support), and the health system (clinic decongestion, efficient service delivery). ART clubs, 15-30 clients who usually meet within the community, are one of the most common DSD options. However, evidence about the quality of care (QoC) delivered in DSD is still limited.</p> <p><b>Materials and Methods:</b> We conducted a concurrent triangulation mixed methods study as part of the Test & Treat project in northwest Tanzania. We surveyed QoC among stable clients and health care workers (HCW) comparing between clinics and clubs. The Donabedian framework structured the analysis into three levels of assessment: structure (staff, equipment, supplies, venue), processes (time-spent, screenings, information, HCW-attitude), and outcomes (viral load, CD4 count, self-worth, health-status).</p> <p><b>Results: </b>We surveyed 629 clients (40% in club) and conducted eight focus group discussions, while 24 HCW (25% in club) were surveyed and 22 individual interviews were conducted. Quantitative results revealed that in terms of structure, clubs fared better than clinics except for perceived adequacy of service delivery venue (94.4% vs 50.0%, p=0.013). For processes, time spent receiving care was significantly more in clinics than clubs (119.9 vs 49.9 minutes, p=<0.001). Regarding outcomes, the proportion of clients with recent viral load <50 copies/ml was higher in clinics than clubs (100% vs 94.4%, p=<0.001). Qualitative results indicated that quality care was perceived similarly among clients in clinics and clubs but for different reasons. Clinics were generally perceived as places with expertise and clubs as efficient places with peer-support and empathy. In describing QoC, HCW emphasized structure-related attributes while clients focused on processes. Outcomes-related themes such as improved client health status, self-worth, and confidentiality were similarly perceived across clients and HCW.</p> <p><b>Conclusion:</b> We found better structure and process of care in clubs than clinics with comparable outcomes. While QoC was perceived similarly in clinics and clubs, its meaning was understood differently between clients. DSD catered to individual needs of clients, either technical care in the clinic or proximate and social care in the club. Our findings highlight that both clinic and DSD care are required as many elements of QoC were individually perceived.</p>
Integrating Hypertension and Cardiovascular Diseases Care Into Existing HIV Services Package in Botswana (InterCARE)
ClinicalTrials.gov study NCT05414526. IPD Sharing: NO. Countries: 1. Publications: 3.
Comparison of Door-to-door Versus Community Gathering to Provide HIV Counseling and Testing Services in Rural Lesotho
ClinicalTrials.gov study NCT01459120. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluation of the Integration of Ag-RDTs for COVID-19 in MNCH, HIV and TB Services in Cameroon and Kenya
ClinicalTrials.gov study NCT05498727. IPD Sharing: YES. Countries: 2. Publications: 1.
User-friendly HIV Testing and Counseling Services
ClinicalTrials.gov study NCT04585165. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Trial to Improve Access to PMTCT Services and Reduce HIV Transmission From Mother to Child
ClinicalTrials.gov study NCT01932138. IPD Sharing: Not stated. Countries: 1. Publications: 2.
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.