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116
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Dataset results
116 results for “HIV reservoir”
Safety and Efficacy of Romidepsin and the Therapeutic Vaccine Vacc-4x for Reduction of the Latent HIV-1 Reservoir
ClinicalTrials.gov study NCT02092116. IPD Sharing: NO. Countries: 1. Publications: 2.
Rapid biphasic decay of intact and defective HIV DNA reservoir during acute treated HIV disease
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A cohort-based study of host gene expression: tumor suppressor and innate immune/inflammatory pathways associated with the HIV reservoir size
<p>The major barrier to an HIV cure is the HIV reservoir: latently-infected cells that persist despite effective antiretroviral therapy (ART). Most prior studies of host genetic predictors of HIV control have focused on "elite controllers," rare individuals able to control virus in the absence of ART. However, there have been few genetic studies among ART-suppressed non-controllers, who make up the majority of people living with HIV (PLWH). We performed host RNA sequencing and HIV reservoir quantification (total DNA [tDNA], unspliced RNA [usRNA], intact DNA) from peripheral CD4+ T cells from 191 HIV+ ART-suppressed non-controllers. After adjusting for nadir CD4+ count, timing of ART initiation, and genetic ancestry, we identified two host genes for which higher expression was significantly associated with smaller total DNA viral reservoir size, <em>P3H3</em> and <em>NBL1</em>, both known tumor suppressor genes. We then identified 17 host genes for which lower expression was associated with higher residual transcription (HIV usRNA). These included novel associations with membrane channel (<em>KCNJ2</em>, <em>GJB2</em>), inflammasome (<em>IL1A, CSF3, TNFAIP5, TNFAIP6, TNFAIP9, CXCL3, CXCL10</em>), and innate immunity (TLR7) genes (FDR-adjusted q<0.05). Gene set enrichment analyses further identified significant associations of HIV usRNA with TLR4/microbial translocation (q=0.006), IL-1/NRLP3 inflammasome (q=0.008), and IL-10 (q=0.037) signaling. Protein validation assays using ELISA and multiplex cytokine assays supported these observed inverse host gene correlations, with P3H3, IL-10, and TNF-a protein associations achieving statistical significance (p<0.05). Of note, plasma IL-10 was also significantly inversely associated with HIV DNA (p=0.016). HIV intact DNA was not associated with differential host gene expression, although this may have been due to a large number of undetectable values in our study. Further data are needed to validate these findings, including functional genomic studies, larger cohorts including underrepresented PLWH in research, and those including dedicated assays to measure the replication-competent HIV reservoir.</p>
HIV Persistence and Viral Reservoirs
ClinicalTrials.gov study NCT01025427. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Therapeutic Intensification Plus Immunomodulation to Decrease the HIV-1 Viral Reservoir
ClinicalTrials.gov study NCT00976404. IPD Sharing: Not stated. Countries: 1. Publications: 1.
MMF for HIV Reservoir Reduction
ClinicalTrials.gov study NCT03262441. IPD Sharing: NO. Countries: 1. Publications: 2.
Reducing the Residual Reservoir of HIV-1 Infected Cells in Patients Receiving Antiretroviral Therapy
ClinicalTrials.gov study NCT02471430. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Combining TLR9 Agonist With bNAbs for Reservoir Reduction and Immunological Control of HIV
ClinicalTrials.gov study NCT03837756. IPD Sharing: YES. Countries: 4. Publications: 1.
PD-1 Inhibition to Determine CNS Reservoir of HIV-Infection
ClinicalTrials.gov study NCT03239899. IPD Sharing: YES. Countries: 1. Publications: 1.
Research In Viral Eradication of HIV Reservoirs
ClinicalTrials.gov study NCT02336074. IPD Sharing: Not stated. Countries: 1. Publications: 42.
Perturbing of HIV Reservoir With Immune Stimulation
ClinicalTrials.gov study NCT02707692. IPD Sharing: NO. Countries: 1. Publications: 1.
A cohort-based study of host gene expression: tumor suppressor and innate immune/inflammatory pathways associated with the HIV reservoir size
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Effect of an Enfuvirtide-based Anti-HIV Drug Regimen on Latent HIV Reservoirs in Treatment Naive Adults
ClinicalTrials.gov study NCT00051831. IPD Sharing: Not stated. Countries: 2. Publications: 5.
A Study to Evaluate the Safety and Effects of Repeated Doses of 3BNC117-LS and 10-1074-LS on Persistent Viral Reservoirs in People Living With HIV and on Suppressive Antiretroviral Therapy
ClinicalTrials.gov study NCT05612178. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Effects of Dolutegravir Based Regimen on HIV-1 Reservoir and Immune Activation
ClinicalTrials.gov study NCT02557997. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Valproic Acid and Its Effects on HIV Latent Reservoirs
ClinicalTrials.gov study NCT00289952. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Peripheral Reservoir of HIV DNA in Monocytes Pivotal to Cognition in HIV
ClinicalTrials.gov study NCT00782808. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Bryostatin-1 Effect on HIV-1 Latency and Reservoir in HIV-1 Infected Patients Receiving Antiretroviral Treatment
ClinicalTrials.gov study NCT02269605. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Observational Study for the Evaluation of the Role of HIV-1 Tat Protein and Anti-Tat Immune Response In HIV Reservoir
ClinicalTrials.gov study NCT04263207. IPD Sharing: NO. Countries: 1. Publications: 33.
The Effect of Arsenic Trioxide on Eliminating HIV-1 Reservoir Combined With cART
ClinicalTrials.gov study NCT03980665. IPD Sharing: NO. Countries: 1. Publications: 18.
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.