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32 results for “HNF1B”
Ovarian Function and Gynecological Profile of Patients Carrying a Pathogenic Variant of the HNF1B Gene (GYN-HNF1)
ClinicalTrials.gov study NCT04746053. IPD Sharing: NO. Countries: 1. Publications: 3.
Data from: Frequency and characteristics of MODY 1 (HNF4A mutation) and MODY 5 (HNF1B mutation) - Analysis from the DPV database
Objective. To characterize initial presentation and clinical course of patients with hepatocyte nuclear factor (HNF) 4A- and HNF1B-MODY in a multinational registry. Design, setting and participants. Within the Diabetes Patienten Verlaufsdokumentation (DPV) registry, 44 patients with HNF4A- and 35 patients with HNF1B-MODY were characterized and compared with patients < 20years old with type 1 diabetes (T1D)/type 2 diabetes (T2D). Main outcome measure. Clinical and laboratory parameters, therapy, metabolic control, and extrapancreatic symptoms in patients with HNF1B-MODY. Results. Patients with both MODY types were significantly older than T1D patients at diagnosis (HNF4A, 13.8 years and HNF1B, 13.5 years, vs. T1D, 8.8 years, P<0.0001). Mean C-peptide at diagnosis was higher for HNF4A-MODY than for T1D (1.8 vs. 0.9 ng/ml, P <0.01). 36.4% of patients with HNF4A-MODY and 65.7% of patients with HNF1B-MODY were treated with insulin, 20.5% and 8.6% received oral antidiabetics only (p<0.05 and p<0.01 vs. T2D). At the most recent visit, glycated hemoglobin levels were lower in HNF4A- and HNF1B-MODY compared to T1D (mean, 6.5% and 6.1%) than in T1D. In 40% of patients with HNF1B-MODY, extrapancreatic symptoms were reported. Several clinical predictors previously described to differentiate between MODY and T1D or T2D could be revalidated by logistic regression analyses in this cohort.Conclusion The DPV registry enabled us to precisely characterize phenotype and treatment in these two rare MODY types. Although phenotype of HNF4A-and HNF1B-MODY shows distinct differences to T1D and T2D, 38% of patients were initially misclassified as having T1D or T2D.
Data from: Frequency and characteristics of MODY 1 (HNF4A mutation) and MODY 5 (HNF1B mutation) - Analysis from the DPV database
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ChIP-seq of HNF1B in prostate cancer cell line DU145
GEO Series GSE183566. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The effects of HNF1b over-expression in PC3 cells
GEO Series GSE63134. Homo sapiens. 14 samples. Type: Expression profiling by array.
HNF1B induced three-dimensional genome analysis of patient-derived pancreas neoplasm organoids [ChIP-seq]
GEO Series GSE202020. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
An HNF1A truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonising HNF1B function
GEO Series GSE166822. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Topoisomerase I (TOP1) is a functional mitotic interactor of the bookmarking factor HNF1B [RNAseq_786O]
GEO Series GSE245071. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide screening of HNF1b binding sites identifies transcriptional regulation of the Kir4.1/Kir5.1 potassium channel
GEO Series GSE77397. Mus musculus. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
HNF1B induced three-dimensional genome analysis of patient-derived pancreas neoplasm organoids
GEO Series GSE202023. Homo sapiens. 15 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other; Expression profiling by high throughput sequencing.
HNF1B controls epithelial organization and cell polarity during ureteric bud branching and collecting duct morphogenesis
GEO Series GSE106085. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
HNF1B induced three-dimensional genome analysis of patient-derived pancreas neoplasm organoids [RNA-seq]
GEO Series GSE202022. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
mRNA sequencing of embryonic kidney at different stages from wild-type and heterozygous mutants of a novel mouse model carrying a human splicing point-mutation in the Hnf1b-gene
GEO Series GSE159566. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Identification of GLIS3 and HNF1b target genes in kidney
GEO Series GSE240072. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
METTL3-dependent m6A RNA Modifications Orchestrate the HNF1B-associated Redox and the Metabolic Vulnerability in Cancer [RNA-seq]
GEO Series GSE286384. Homo sapiens; Mus musculus. 40 samples. Type: Expression profiling by high throughput sequencing.
Targets of HNF1b mutants in INS-1
GEO Series GSE1590. Rattus norvegicus. 12 samples. Type: Expression profiling by array.
HNF1B induced three-dimensional genome analysis of patient-derived pancreas neoplasm organoids [HiC]
GEO Series GSE202021. Homo sapiens. 5 samples. Type: Other.
METTL3-dependent m6A RNA Modifications Orchestrate the HNF1B-associated Redox and the Metabolic Vulnerability in Cancer [MeRIP-seq]
GEO Series GSE286385. Homo sapiens; Mus musculus. 9 samples. Type: Other.
Bulk ATAC-seq of RPTEC with HNF1B CRISPRi
GEO Series GSE227061. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Topoisomerase I (TOP1) is a functional mitotic interactor of the bookmarking factor HNF1B [RNAseq_KEC]
GEO Series GSE245072. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.