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19 results for “Head direction”
Petrucco et al, Neural dynamics and architecture of the heading direction circuit in a vertebrate brain [Dataset]
<p>Data supporting the paper <a href="https://www.biorxiv.org/content/10.1101/2022.04.27.489672v1.full">Neural dynamics and architecture of the heading direction circuit in a vertebrate brain</a>. </p>
Visual objects refine head direction coding
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Electrophysiology and anatomy data for: Projection-specific integration of convergent thalamic and retrosplenial signals in the presubicular head direction cortex
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Data from: Resolving the heading-direction ambiguity in vertical-beam radar observations of migrating insects
1. Each year, massive numbers of insects fly across the continents at heights of hundreds of metres, carried by the wind, bringing both environmental benefits and serious economic and social costs. To investigate the insects' flight behaviour and their response to winds, entomological radar has proved to be a particularly valuable tool; however, its observations of insect orientation are ambiguous with regard to the head/tail direction and this greatly hinders interpretation of the migrants' flight behaviour. 2. We have developed two related methods of using wind data to resolve the head/tail ambiguity and we have compared their outputs with those from simply assigning the heading direction to be that which is closer to the track direction. We applied all three methods to observations of Australian Plague Locust migrations made with an Insect Monitoring Radar. 3. For the study dataset, some of the headings selected by the simpler method are shown to be clearly incorrect. The two new methods generally agree and reveal a significantly different, and presumably more accurate, relationship of heading direction to track direction. However, use of these methods leads to quite a large proportion of the sample being lost because the wind values, which derive from a regional-scale numerical model, are shown to be incompatible with the radar observations. This exploratory study has moreover demonstrated that locusts are frequently oriented at a large angle to their track, and that quite often their movement is at least slightly tail-first. 4. Both new methods appear to be a significant improvement on the simpler method. As well as providing an accurate representation of migratory flight behaviour, they allow occasions when the model wind values are unreliable to be eliminated from the data sample.
Data for "Multi-scale model of axonal and dendritic polarization by transcranial direct current stimulation in realistic head geometry"
<p>Neural and FEM E-field simulation data generated for Aberra AS, Wang R, Grill WM, Peterchev AV. (2023). "Multi-scale model of axonal and dendritic polarization by transcranial direct current stimulation in realistic head geometry". <i>Brain Stimulation</i>. Dataset includes:</p><ul><li><i>cell_data/ </i>- Coordinates and morphology information for all model neurons</li><li><i>nrn_sim_data/</i> - Polarization data from NEURON simulations for all 25 model neurons included in the study, either in response to uniform E-field or tDCS.</li><li><i>layer_data/ - </i>surface meshes used for placing and orienting neuron models and corresponding sampling grids for CNNs</li><li><i>simnibs/</i> - E-field simulation and head mesh data generated within SimNIBS simulation environment</li></ul><p>To generate figures using these data, use the matlab code stored in the tDCSsim_Aberra2023 repository (https://github.com/Aman-A/tDCSsim_Aberra2023) </p>
Dataset and code for "Tiltable objective microscope visualizes selectivity for head motion direction and dynamics in zebrafish vestibular system", Nat Commun 13, 7622 (2022). https://doi.org/10.1038/s41467-022-35190-9
<p>Dataset and code for "Tiltable objective microscope visualizes selectivity for head motion direction and dynamics in zebrafish vestibular system", Tanimoto, Watakabe, and Higashijima.</p> <p> </p> <p>The spreadsheet files contain source data for the figures.</p> <p>The file named "register_rotated_images_demo.zip" contains the MATLAB code, example image data, and instruction text data. To use the code, unzip the file and follow the instructions in the "readme.txt" file. The file named "register_rotated_images_demo_output.zip" contains expected output image data.</p> <p> </p>
Effect of Goal-directed Fluid Therapy Using Stroke Volume Variation in Patients Undergoing Free Flap Reconstruction After Head and Neck Cancer Resection
ClinicalTrials.gov study NCT02003066. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Resolving the heading-direction ambiguity in vertical-beam radar observations of migrating insects
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Head Motion in Pediatric Patients Endotracheally Intubated With Video Laryngoscopy Versus Direct Laryngoscopy
ClinicalTrials.gov study NCT02405390. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Nucleus reuniens of the thalamus contains head direction cells
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p63 Directs Subtype Specific Gene Expression in HPV+ Head and Neck Squamous Cell Carcinoma
GEO Series GSE182133. Homo sapiens. 25 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
DATA: A thalamic reticular circuit for head direction cell tuning and spatial navigation
<p>As we navigate in space, external landmarks and internal information guide our movement. Circuit and synaptic mechanisms that integrate these cues with head-direction (HD) signals remain, however, unclear. We identify an excitatory synaptic projection from the presubiculum (PreS) and the multisensory-associative retrosplenial cortex (RSC) to the anterodorsal thalamic reticular nucleus (TRN), so far classically implied in gating sensory information flow. <em>In vitro</em>, projections to TRN involve AMPA/NMDA-type glutamate receptors that initiate TRN cell burst discharge and feedforward inhibition of anterior thalamic nuclei. <em>In vivo</em>, chemogenetic anterodorsal TRN inhibition modulates PreS/RSC-induced anterior thalamic firing dynamics, broadens the tuning of thalamic HD cells, and lead to preferential use of allo- over egocentric search strategies in the Morris water maze. TRN-dependent thalamic inhibition is thus an integral part of limbic navigational circuits wherein it coordinates external sensory and internal HD signals to regulate the choice of search strategies during spatial navigation.</p>
Data from: Non-rhythmic head-direction cells in the parahippocampal region are not constrained by attractor network dynamics
Computational models postulate that HD cells are part of an attractor network integrating angular head turns. This network requires inputs from visual landmarks to anchor the HD signal to the external world. We investigated whether information about HD and visual landmarks is integrated in the medial entorhinal cortex and parasubiculum, resulting in neurons expressing a conjunctive code for HD and visual landmarks. We found that parahippocampal HD cells could be divided into two classes based on their theta-rhythmic activity: non-rhythmic and theta-rhythmic HD cells. Manipulations of the visual landmarks caused tuning curve alterations in most HD cells, with the largest visually driven changes observed in non-rhythmic HD cells. Importantly, the tuning modifications of non-rhythmic HD cells were often non-coherent across cells, refuting the notion that attractor-like dynamics control non-rhythmic HD cells. These findings reveal a new population of non-rhythmic HD cells whose malleable organization is controlled by visual landmarks.
A Clinical Study to Investigate the Efficacy of Tigilanol Tiglate Directly in Head and Neck Cancer
ClinicalTrials.gov study NCT05608876. IPD Sharing: NO. Countries: 2. Publications: 0.
A Direct Head-to-head Comparison of Ustekinumab with Infliximab for the Treatment of Ulcerative Colitis
ClinicalTrials.gov study NCT06786507. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Intensive Symptom Surveillance Guided by Machine Learning-Directed Risk Stratification in Patients With Non-Metastatic Head and Neck Cancer, The INSIGHT Trial
ClinicalTrials.gov study NCT05338905. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Non-rhythmic head-direction cells in the parahippocampal region are not constrained by attractor network dynamics
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The dual pathway inhibitor rigosertib is effective in direct-patient tumor xenografts of head and neck squamous cell carcinomas
GEO Series GSE47864. Homo sapiens. 16 samples. Type: Expression profiling by array.
Dataset related to article "Metastasis-directed stereotactic body radiation therapy in the management of oligometastatic head and neck cancer"
<p>This record contains raw data related to article "Metastasis-directed stereotactic body radiation therapy in the management of oligometastatic head and neck cancer"</p> <p><strong>Introduction: </strong>Recently major efforts have been made to define the oligometastatic setting, but for head and neck cancer (HNC) limited data are available. We aimed to evaluate outcome of oligometastatic HNC treated with Stereotactic body radiotherapy (SBRT) as metastasis-directed therapy.</p> <p><strong>Materials and methods: </strong>We analyzed patients treated with SBRT on a maximum of five oligometastases from HNC, in up to two organs. Concomitant treatment was allowed. End points were toxicity, local control of treated metastases (LC), progression-free survival (PFS) and overall survival (OS).</p> <p><strong>Results: </strong>48 consecutive patients and 71 lesions were treated. With a follow-up of 20.2 months, most common primary tumors were larynx (29.2%) and salivary glands (29.2%), while common site of metastases was lung (59.1%). Median dose was 48 Gy (21-75) in 3-8 fractions. Treatment was well tolerated, with two patients reporting mild pain and nausea. LC rates at 1 and 2 years were 83.1% and 70.2%. Previous local therapy (HR 4.97; p = 0.002), oligoprogression (HR 4.07; p = 0.031) and untreated metastases (HR 4.19; p = 0.027) were associated with worse LC. PFS at 1 and 2 years were 42.2% and 20.0%. Increasing age (HR 1.03; p = 0.010), non-adenoid cystic carcinoma (HR 2.57; p = 0.034) and non-lung metastases (HR 2.20; p = 0.025) were associated with worse PFS. One- and 2-years OS were 81.0% and 67.1%. Worse performance status (HR 2.91; p = 0.049), non-salivary primary (HR 19.9; p = 0.005), non-lung metastases (HR 2.96; p = 0.040) were correlated with inferior OS.</p> <p><strong>Conclusions: </strong>SBRT can be considered a safe metastasis-directed therapy in oligometastatic HNC. Efficacy of the treatment seems to be higher when administered upfront in the management of metastatic disease; however, selection of patients need to be improved due to the relevant risk of appearance of new metastatic site after SBRT.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.