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368 results for “Hepatitis B virus”
Intra-host quasispecies reconstructions resemble inter-host variability in transmitted chronic Hepatitis B Virus strains (Dataset)
<p>Data used for publication "Intra-host quasispecies reconstructions resemble inter-host variability in transmitted chronic Hepatitis B Virus strains" submitted to the <em>Journal of Medical Virology</em>. Includes example code and selected sequence, tree, and data files.</p>
Figure 1 in Serological prevalence of hepatitis B virus (HBV) in Mardan district, Khyber Pakhtunkhwa, Pakistan
Figure 1. Map of the Khyber Pakhtunkhwa (KP), Pakistan. The district Mardan in encircled, where the present study was conducted for determining the prevalence of active HCV infection and genotypic distribution in the year from 2017-2020.
Supplementary Tables - Re-analysis of hepatitis B virus integration sites reveals potential new loci associated with oncogenesis in hepatocellular carcinoma
<p>------------------------------------------------------------</p> <p><strong>Supplementary Tables</strong></p> <p>supplementary_table.xlsx</p> <ul> <li>T2T-CHM13_human</li> <li>T2T-CHM13_hbv</li> <li>GRCh38_human</li> <li>GRCh38_hbv</li> <li>GRCh_human_annotation</li> <li>meta</li> </ul> <p>------------------------------------------------------------</p> <p><strong>Re-analysis of hepatitis B virus integration sites reveals potential new loci associated with oncogenesis in hepatocellular carcinoma</strong><br> <a href="https://doi.org/10.5501/wjv.v12.i3.209">https://doi.org/10.5501/wjv.v12.i3.209</a></p><br> <p><strong>BACKGROUND</strong></p> <p>Hepatitis B virus (HBV) is a major cause of hepatocellular carcinoma (HCC). HBV DNA can get integrated into the hepatocyte genome to promote carcinogenesis. However, the precise mechanism by which the integrated HBV genome promotes HCC has not been elucidated.</p> <p><strong>AIM</strong></p> <p>To analyze the features of HBV integration in HCC using a new reference database and integration detection method.</p> <p><strong>METHODS</strong></p> <p>Published data, consisting of 426 Liver tumor samples and 426 paired adjacent non-tumor samples, were re-analyzed to identify the integration sites. Genome Reference Consortium Human Build 38 (GRCh38) and Telomere-to-Telomere Consortium CHM13 (T2T-CHM13 (v2.0)) were used as the human reference genomes. In contrast, human genome 19 (hg19) was used in the original study. In addition, GRIDSS VIRUSBreakend was used to detect HBV integration sites, whereas high-throughput viral integration detection (HIVID) was applied in the original study (HIVID-hg19).</p> <p><strong>RESULTS</strong></p> <p>A total of 5361 integration sites were detected using T2T-CHM13. In the tumor samples, integration hotspots in the cancer driver genes, such as TERT and KMT2B, were consistent with those in the original study. GRIDSS VIRUSBreakend detected integrations in more samples than by HIVID-hg19. Enrichment of integration was observed at chromosome 11q13.3, including the CCND1 pro-moter, in tumor samples. Recurrent integration sites were observed in mitochondrial genes.</p> <p><strong>CONCLUSION</strong></p> <p>GRIDSS VIRUSBreakend using T2T-CHM13 is accurate and sensitive in detecting HBV integration. Re-analysis provides new insights into the regions of HBV integration and their potential roles in HCC development.</p>
Joint host-pathogen genomic analysis identifies hepatitis B virus mutations associated with human NTCP and HLA class I variation
<p>Summary statistics for "Joint host-pathogen genomic analysis identifies hepatitis B virus mutations associated with human NTCP and HLA class I variation" </p><p>Files are organized in the following directory structure:</p><p><strong>G2G/</strong> - Summary statistics of G2G associations (SNPs, HLA, and gene-level analysis). </p><p><strong>HLA/ </strong>- Peptide binding prediction results</p><p><strong>preS1_haplotypes/ - </strong>Resolved intra-host haplotypes of the preS1 binding region. </p><p><strong>DnDs/</strong> - Calculation of intra-host positive selection, within the preS1 binding region. </p><p> </p>
Hepatitis B Virus - Geneious BAM files
<p>BAM files for specimens assembled in Geneious including their genotype specific references.</p>
Efficacy and in vitro pharmacological assessment of novel N-hydroxypyridinediones as hepatitis B virus ribonuclease H inhibitors
<p>The data here is summarized in Efficacy and in vitro pharmacological assessment of novel N-hydroxypyridinediones as hepatitis B virus ribonuclease H inhibitors by Woodson, et al. </p>
Long-Term Survival and Curative-Intent Treatment in Hepatitis B or C Virus-Associated Hepatocellular Carcinoma Patients Diagnosed during Screening
<p>We uploaded the image of the mansucript <strong>Long-Term Survival and Curative-Intent Treatment in Hepatitis B or C Virus-Associated Hepatocellular Carcinoma Patients Diagnosed during Screening </strong>accepted on Biology.</p>
A Study of Different Combination Regimens Including JNJ-73763989 and/or JNJ-56136379 for the Treatment of Chronic Hepatitis B Virus Infection
ClinicalTrials.gov study NCT03982186. IPD Sharing: YES. Countries: 19. Publications: 2.
A Study of JNJ-73763989, JNJ-56136379, Nucleos(t)Ide Analogs, and Pegylated Interferon Alpha-2a in Virologically Suppressed Participants With Chronic Hepatitis B Virus Infection
ClinicalTrials.gov study NCT04667104. IPD Sharing: YES. Countries: 4. Publications: 1.
Entecavir/Pegylated Interferon in Immune Tolerant Children With Chronic Hepatitis B Virus (HBV) Infection
ClinicalTrials.gov study NCT01368497. IPD Sharing: YES. Countries: 2. Publications: 1.
An Efficacy, Safety, and Pharmacokinetics Study of JNJ-56136379 in Participants With Chronic Hepatitis B Virus Infection
ClinicalTrials.gov study NCT03361956. IPD Sharing: Not stated. Countries: 19. Publications: 3.
A Study Evaluating ABI-H0731+ Entecavir vs Entecavir Alone for the Treatment of Viremic HBeAg-positive Participants With Chronic Hepatitis B Virus Infection (cHBV)
ClinicalTrials.gov study NCT03577171. IPD Sharing: Not stated. Countries: 5. Publications: 1.
The Effect of Viral Load on Intrahepatic Recurrence in Hepatitis B Virus (HBV)-Related Hepatocellular Carcinoma (HCC)
ClinicalTrials.gov study NCT00397540. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Study of Pegasys (Peginterferon Alfa-2a) Added to Nucleos(t)Ide Analogue Treatment in Participants With HBeAg-Negative Chronic Hepatitis B Genotype D Showing Stable Hepatitis B Virus (HBV) Deoxyribo
ClinicalTrials.gov study NCT01706575. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study of VIR-3434 in Healthy Volunteers and Patients With Chronic Hepatitis B Virus Infection
ClinicalTrials.gov study NCT04423393. IPD Sharing: NO. Countries: 7. Publications: 1.
A Phase III Study of the Safety and Efficacy of Entecavir in Pediatric Patients With Chronic Hepatitis B Virus Infection
ClinicalTrials.gov study NCT01079806. IPD Sharing: Not stated. Countries: 14. Publications: 1.
Safety and Immunogenicity Study of the Hepatitis B Virus (HBV) Vaccine, HEPLISAV Compared to Engerix-B Vaccine
ClinicalTrials.gov study NCT01005407. IPD Sharing: NO. Countries: 2. Publications: 1.
Study of Entecavir in Patients With Chronic Hepatitis B Virus (HBV) Infection
ClinicalTrials.gov study NCT00388674. IPD Sharing: Not stated. Countries: 24. Publications: 3.
Part A: Drug Interaction Study of Sofosbuvir and Antiretroviral Therapy (ART) Combinations in HIV and Hepatitis C Virus (HCV) Co-infected Patients. Part B: Efficacy and Safety of Sofosbuvir for 12 Wee
ClinicalTrials.gov study NCT01565889. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of Pegylated Interferon Alfa-2a and Lamivudine in Patients With HBeAg-Negative Chronic Hepatitis B Virus (HBV)
ClinicalTrials.gov study NCT01095835. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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Allen Brain Atlas
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.