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509 results for “Hepatitis C Virus”
MD simulation data: An Entropic Safety Catch Controls Hepatitis C Virus Entry and Antibody Resistance
<p><strong>Background</strong></p> <p>Equilibration, relaxation and production runs were performed on GPUs using the CUDA version of PMEMD in AMBER 16 and AMBER ff14SB force field. Minimisation steps were performed on a CPU using PMEMD in AMBER 16 and the AMBER ff14SB force field. All software is available from http://ambermd.org/. </p> <p><strong>Contents</strong></p> <p>There are three tarball (<strong>.tar.gz</strong>) files containing the <strong>core simulation data</strong>: one for wild type (WT), the second for the I438V A524T mutant and the third for the S449P mutant. Each contains:</p> <p>1. a source PDB (<strong>.pdb</strong>) file</p> <p>2. Five AMBER trajectory (<strong>.nc</strong>) files for five independent MD simulations, numbered 1 to 5. <strong>Note: </strong>each of these files is over 2GB.</p> <p>There is an additional tarball containing the <strong>control files</strong> <strong>and scripts</strong> used for running the MD simulations:</p> <p>1. Multiple control (<strong>.ctl</strong>) files numbered 1 to 10 that are used to minimize (<strong>min</strong> prefix), relax (<strong>rel</strong> prefix) and equilibrate (<strong>equ</strong> prefix) the model</p> <p>2. Executable <strong>do_md</strong> that performed all the minimisation, relaxation and equilibration steps</p> <p>3. control file <strong>prod.ctl</strong> used for the production run </p> <p>4. Executable <strong>run_prod</strong> that was used to perform the production run</p> <p>5. Two control files (<strong>prod_short.ctl </strong>and <strong>prod_short_2.ctl</strong>) for the short runs used to de-correlate the simulation for the independent runs</p> <p>6. Executable <strong>run_short</strong> and <strong>run_short_2</strong> used to carry out the de-correlated production runs.</p>
Raw NGS data for the study 'Spouse-to-spouse Transmission and Evolution of Hypervariable Region 1 and 5’ Untraslated Region of Hepatitis C Virus Analyzed by Next-generation Sequencing'
<p>This file contains the original next-generation sequencing data (raw sequences in fastq format) which were analyzed in the study titled: "Spouse-to-spouse Transmission and Evolution of Hypervariable Region 1 and 5’ Untraslated Region of Hepatitis C Virus Analyzed by Next-generation Sequencing".</p> <p> </p> <p> </p>
Efficacy and Safety of Glecaprevir (ABT-493)/Pibrentasvir (ABT 530) (GLE/PIB) in Combination With Sofosbuvir and Ribavirin in Participants With Hepatitis C Virus Who Did Not Respond to Treatment in a
ClinicalTrials.gov study NCT02939989. IPD Sharing: YES. Countries: 12. Publications: 1.
Glecaprevir/Pibrentasvir Fixed-dose Combination Treatment for Acute Hepatitis C Virus Infection
ClinicalTrials.gov study NCT04042740. IPD Sharing: YES. Countries: 2. Publications: 1.
Original NGS dataset from publication "Next-generation sequencing analysis of a cluster of hepatitis C virus infections in a haematology and oncology center".
<p>Original hepatitis C virus hypervariable region 1 NGS sequences in fastq format from patients analyzed in the study "Next-generation sequencing analysis of a cluster of hepatitis C virus infections in a haematology and oncology center". </p> <p> </p>
MD simulation data: Intrinsic disorder is a conserved feature of hepatitis C virus E2 glycoprotein
<p><strong>Background</strong></p> <p>Equilibration, relaxation and production runs were performed on GPUs using the CUDA version of PMEMD in AMBER 16 and AMBER ff14SB force field. Minimisation steps were performed on a CPU using PMEMD in AMBER 16 and the AMBER ff14SB force field. The GLYCAM_06j-1 force field was used for the simulations of the glycosylated E2. All software is available from http://ambermd.org/. </p> <p><strong>Contents</strong></p> <p>There are three tarball (<strong>.tar.gz</strong>) files, one for each of the HCV strain investigated. </p> <p>The contents of each tarball is as follows:</p> <p>1. a source PDB (<strong>.pdb</strong>) file</p> <p>2. <strong>leap.scr</strong> - a script used to create the .prmtop and .inpcrd files</p> <p>3. Two AMBER parameter/topology (<strong>.prmtop</strong>) (one with hydrogen mass repartitioning) and an AMBER coordinate (<strong>.inpcrd</strong>) file </p> <p>4. Multiple control (<strong>.ctl</strong>) files numbered 1 to 10 that are used to minimize (<strong>min</strong> prefix), relax (<strong>rel</strong> prefix) and equilibrate (<strong>equ</strong> prefix) the model</p> <p>5. Executable <strong>do_md</strong> that performed all the minimisation, relaxation and equilibration steps</p> <p>6. File <strong>parmed.txt</strong> used to repartition the hydrogen atom mass (for the unglycosylated simulations)</p> <p>7. control file <strong>prod.ctl</strong> used for the production run </p> <p>8. Executable <strong>run_prod</strong> that was used to perform the production run</p> <p>9. Two control files (<strong>prod_short.ctl </strong>and <strong>prod_short_2.ctl</strong>) for the short runs used to de-correlate the simulation for the independent runs</p> <p>10. Executable <strong>run_short</strong> and <strong>run_short_2</strong> used to carry out the de-correlated production runs.</p> <p>10. Five AMBER trajectory (<strong>.nc</strong>) files for five independent MD simulations, numbered 1 to 5. <strong>Note: </strong>each of these files is over 2GB.</p>
Long-Term Survival and Curative-Intent Treatment in Hepatitis B or C Virus-Associated Hepatocellular Carcinoma Patients Diagnosed during Screening
<p>We uploaded the image of the mansucript <strong>Long-Term Survival and Curative-Intent Treatment in Hepatitis B or C Virus-Associated Hepatocellular Carcinoma Patients Diagnosed during Screening </strong>accepted on Biology.</p>
Sofosbuvir With Pegylated Interferon and Ribavirin Hepatitis C Virus (HCV) Genotypes 1,4,5,6
ClinicalTrials.gov study NCT01329978. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Study to Determine the Safety and Effectiveness of Antiviral Combination Therapy to Treat Hepatitis C Virus (HCV) in Patients Who Have Previously Not Received the Standard of Care
ClinicalTrials.gov study NCT01359644. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Association of Hepatitis C Virus With Breast Cancer
ClinicalTrials.gov study NCT04090164. IPD Sharing: NO. Countries: 1. Publications: 3.
Efficacy and Safety of Sofosbuvir/Velpatasvir Fixed Dose Combination for 12 Weeks in Adults With Chronic Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV)-1 Coinfection
ClinicalTrials.gov study NCT02480712. IPD Sharing: YES. Countries: 1. Publications: 1.
Pegylated Interferon Alfa-2a Maintenance Therapy and Liver Disease Progression in People Infected With Both HIV and Hepatitis C Virus (HCV)
ClinicalTrials.gov study NCT00078403. IPD Sharing: Not stated. Countries: 2. Publications: 12.
Ledipasvir/Sofosbuvir in Adults With Chronic Hepatitis C Virus (HCV) Infection Who Are on Dialysis for End Stage Renal Disease
ClinicalTrials.gov study NCT03036839. IPD Sharing: YES. Countries: 5. Publications: 1.
PROPHESYS 1: An Observational Study on Predictors of Response in Treatment-naïve Patients With Chronic Hepatitis C Virus (HCV)Treated With Pegasys (Peginterferon Alfa-2a)
ClinicalTrials.gov study NCT01070550. IPD Sharing: Not stated. Countries: 14. Publications: 2.
Study of Sirolimus Versus Mycophenolate Liver Transplant Recipients With Recurrent Hepatitis C Virus (HCV)
ClinicalTrials.gov study NCT01134952. IPD Sharing: Not stated. Countries: 1. Publications: 14.
Quality of Life Measurement in Treatment Naïve Patients With Hepatitis C Virus (HCV) Genotype 1 (GT1) Suffering From Fatigue and Receiving Ombitasvir, Paritaprevir, and Ritonavir and Dasabuvir (Viekir
ClinicalTrials.gov study NCT03002818. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Study of Daclatasvir (BMS-790052) and Simeprevir (TMC435) in Patients With Genotype 1 Chronic Hepatitis C Virus
ClinicalTrials.gov study NCT01628692. IPD Sharing: Not stated. Countries: 6. Publications: 1.
Evaluating the Effectiveness of Boceprevir, Pegylated-Interferon Alfa 2b and Ribavirin in Treating Hepatitis C Virus (HCV) Infection in Adults With HIV and HCV Infection
ClinicalTrials.gov study NCT01482767. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Short Term Treatment With BI 201335, Peginterferon-alpha 2a and Ribavirin in Hepatitis c Virus Genotype-1 Treatment-naïve Patients (SILEN-C3)
ClinicalTrials.gov study NCT00984620. IPD Sharing: Not stated. Countries: 6. Publications: 1.
Safety and Efficacy of Ledipasvir/Sofosbuvir (LDV/SOF) Fixed-Dose Combination (FDC) for 6 Weeks in Adults With Acute Genotype 1 or 4 Hepatitis C Virus (HCV) and Chronic Human Immunodeficiency Virus (H
ClinicalTrials.gov study NCT02457611. IPD Sharing: YES. Countries: 2. Publications: 1.
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International Brain Laboratory public data
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OpenNeuro
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