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15 results for “Herbal Products”
Complementary authentication of Chinese herbal products to treat endometriosis using DNA metabarcoding and HPTLC shows a high level of variability
<p>Traditional Chinese Medicine (TCM) is popular for the treatment of endometriosis, a complex gynecological disease that affects 10% of women globally. The growing market for TCMs has yielded a significant incentive for product adulteration, and although emerging technologies show promise to improve their quality control, many challenges remain. We tested the authenticity of two traditional Chinese herbal formulae used in women’s healthcare for the treatment of endometriosis, known as <em>Gui Zhi Fu Ling Wan</em> (FL) and <em>Ge Xia Zhu Yu Tang</em> (GX). Dual-locus DNA metabarcoding analysis coupled with high-performance thin-layer chromatography (HPTLC) were used to authenticate 19 FL and six GX commercial herbal products, as well as three ad hoc prepared artificial mixtures. HPTLC was able to detect most of the expected ingredients via comparative component analysis. DNA metabarcoding was able to detect an unexpected species diversity in the products, including 38 unexpected taxa. Chromatography has resolution for all species indirectly through identification of marker compounds for the different species ingredients. Metabarcoding on the other hand yields an overview of species diversity in each sample, but interpretation of the results can be challenging. Detected species might not be present in quantities that matter, and without validated quantification some detected species can be hard to interpret. Comparative analysis of the two analytical approaches also reveals that DNA for species might be absent or too fragmented to amplify as the relevant chemical marker compounds can be detected but no amplicons assigned to the same species. Our study emphasizes that integrating DNA metabarcoding with phytochemical analysis brings valuable data for comprehensive authentication of Traditional Chinese Medicines ensuring their quality and safe use.</p>
Efficacy and Safety of a Herbal Medicinal Product (Dry Extract BNO 1016) in Patients With Acute Rhinosinusitis
ClinicalTrials.gov study NCT01146860. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data for "Rotational grazing and multispecies herbal leys increase productivity in temperate pastoral systems – a meta-analysis"
<p>Supplementary files for systematic review and meta-analysis: "Rotational grazing and multispecies herbal leys increase productivity in temperate pastoral systems – a meta-analysis"</p>
DNA metabarcoding authentication of Ayurvedic herbal products on the European market raises concerns of quality and fidelity
<p>Ayurveda is one of the oldest systems of medicine in the world, but the growing commercial interest in Ayurveda based products has increased the incentive for adulteration and substitution within this herbal market. Fraudulent practices such as the use of undeclared fillers and use of other species of inferior quality is driven both by the increased as well as insufficient supply capacity of especially wild plant species. Developing novel strategies to exhaustively assess and monitor both the quality of raw materials and final marketed herbal products is a challenge in herbal pharmacovigilance. Seventy-nine Ayurvedic herbal products sold as tablets, capsules, powders and extracts were randomly purchased via e-commerce and pharmacies across Europe, and DNA metabarcoding was used to assess the ability of this method to authenticate these products. Our analysis reveals that only two out of 12 single ingredient products contained only one species as labelled, eight out of 27 multiple ingredient products contained none of the species listed on the label, and the remaining 19 products contained 1 to 5 of the species listed on the label along with many other species not specified on the label. The fidelity for single ingredient products was 67 %, the overall ingredient fidelity for multi ingredient products was 21 %, and for all products 24 %. The low level of fidelity raises concerns about the reliability of the products, and detection of threatened species raises further concerns about illegal plant trade. The study highlights the necessity for quality control of the marketed herbal products and shows that DNA metabarcoding is an effective analytical approach to authenticate complex multi ingredient herbal products. However, effort needs to be done to standardize the protocols for DNA metabarcoding before this approach can be implemented as routine analytical approaches for plant identification, and approved for use in regulated procedures.</p>
Effect of Qi-tonifying Chinese Herbal Products for Treatment of Allergic Rhinitis
ClinicalTrials.gov study NCT01631032. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Effects of Herbal Products on Reduction of Radiation-induced Dermatitis in Breast Cancer Patients
ClinicalTrials.gov study NCT02922244. IPD Sharing: YES. Countries: 1. Publications: 8.
Data from: Comparative authentication of Hypericum perforatum herbal products using DNA metabarcoding, TLC and HPLC-MS
Many herbal products have a long history of use, but there are increasing concerns over product efficacy, safety and quality in the wake of recent cases exposing discrepancies between labeling and constituents. When it comes to St. John's wort (Hypericum perforatum L.) herbal products, there is limited oversight, frequent off-label use and insufficient monitoring of adverse drug reactions. In this study, we use amplicon metabarcoding (AMB) to authenticate 78 H. perforatum herbal products and evaluate its ability to detect substitution compared to standard methods using thin-layer chromatography (TLC) and high performance liquid chromatography coupled with mass spectrometry (HPLC-MS). Hypericum perforatum was detected in 68% of the products using AMB. Furthermore, AMB detected incongruence between constituent species and those listed on the label in all products. Neither TLC nor HPLC-MS could be used to unambiguously identify H. perforatum. They are accurate methods for authenticating presence of the target compounds, but have limited efficiency in detecting infrageneric substitution and do not yield any information on other plant ingredients in the products. Random post-marketing AMB of herbal products by regulatory agencies could raise awareness among consumers of substitution and would provide an incentive to manufacturers to increase quality control from raw ingredients to commercialized products.
Nicotine Pharmacokinetic Study of Heated Tobacco and Heated Herbal Products
ClinicalTrials.gov study NCT06093659. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Comparative authentication of Hypericum perforatum herbal products using DNA metabarcoding, TLC and HPLC-MS
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Effects of Herbal Products on Metabolism and Hunger
ClinicalTrials.gov study NCT00198952. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaulation of Interaction Between Herbal Products and Anticoagulants
ClinicalTrials.gov study NCT00071682. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Clinical Trial on the Efficacy of a Combination Herbal Product, Biotropics' Nu Femme, on Menopausal Symptoms and Quality of Life in Women
ClinicalTrials.gov study NCT02269891. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Efficacy and Safety of Two Dosages of a Herbal Medicinal Product (Dry Extract BNO 1016) in Chronic Rhinosinusitis
ClinicalTrials.gov study NCT01706484. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of Herbal Products on Platelet Function and Clotting
ClinicalTrials.gov study NCT02008981. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Clinical Trial on a Food Supplement With Melatonin and Herbal Products to Improve Sleep Quality
ClinicalTrials.gov study NCT05459272. IPD Sharing: NO. Countries: 1. Publications: 0.
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