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Dataset results
10 results for “Hippocampal connectivity”
Hippocampal hub neurons maintain distinct connectivity throughout their lifetime
<p>The temporal embryonic origins of cortical GABA neurons are critical for their specialization. In the neonatal hippocampus, GABA cells born the earliest (ebGABAs) operate as ‘hubs’ by orchestrating population synchrony. However, their adult fate remains largely unknown. To fill this gap, we have examined CA1 ebGABAs using a combination of electrophysiology, neurochemical analysis, optogenetic connectivity mapping as well as ex vivo and in vivo calcium imaging. We show that CA1 ebGABAs not only operate as hubs during development, but also maintain distinct morpho-physiological and connectivity profiles, including a bias for long-range targets and local excitatory inputs. In vivo, ebGABAs are activated during locomotion, correlate with CA1 cell assemblies and display high functional connectivity. Hence, ebGABAs are specified from birth to ensure unique functions throughout their lifetime. In the adult brain, this may take the form of a long-range hub role through the coordination of cell assemblies across distant regions.</p>
Impact of the entorhinal feed-forward connection to the CA3 on hippocampal coding
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Data from: Hippocampal-occipital connectivity reflects autobiographical memory deficits in aphantasia
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Stimulation of Parieto-hippocampal Connectivity in Patients With Major Depressive Disorder
ClinicalTrials.gov study NCT04081519. IPD Sharing: NO. Countries: 1. Publications: 5.
Data from: Algal toxin impairs sea lion memory and hippocampal connectivity, with implications for strandings
Domoic acid (DA) is a naturally occurring neurotoxin known to harm marine animals. DA-producing algal blooms are increasing in size and frequency. Although chronic exposure is known to produce brain lesions, the influence of DA toxicosis on behavior in wild animals is unknown. We showed, in a large sample of wild sea lions, that spatial memory deficits are predicted by the extent of right dorsal hippocampal lesions related to natural exposure to DA and that exposure also disrupts hippocampal-thalamic brain networks. Because sea lions are dynamic foragers that rely on flexible navigation, impaired spatial memory may affect survival in the wild.
Data from: Algal toxin impairs sea lion memory and hippocampal connectivity, with implications for strandings
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Efficient generation of human CA3 neurons and modeling hippocampal neuronal connectivity in vitro (single cells)
GEO Series GSE111978. Homo sapiens. 507 samples. Type: Expression profiling by high throughput sequencing.
Efficient generation of human CA3 neurons and modeling hippocampal neuronal connectivity in vitro (bulk)
GEO Series GSE111977. Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing.
A novel hippocampal long-range VIP-GABAergic projection to subiculum contributes to fear memory formation through region-specific connectivity
GEO Series GSE109755. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Efficient generation of human CA3 neurons and modeling hippocampal neuronal connectivity in vitro
GEO Series GSE111979. Homo sapiens. 528 samples. Type: Expression profiling by high throughput sequencing.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.