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5 results for “Hippoglossus”
Raw data and correlation analysis of physiological data sampled from Atlantic halibut (Hippoglossus hippoglossus) for the development of a PBPK model
<p>Raw data sampled from Atlantic halibut <em>(Hippoglossus hippoglossus)</em> for the characterization of physiological parameters for the development of a species-specific physiology-based pharmacokinetic (PBPK) model. Additionally, the document containes imputed data for a PCA analysis and correlation coefficients and the related p-values from a correlation analysis. </p>
Hippoglossus hippoglossus SNP data for coverage-based sex association
<p>Changes in the genetic mechanisms that control sexual determination have occurred independently across the tree of life, and with exceptional frequency in teleost fishes. To investigate the genomic changes underlying the evolution of sexual determination, we sequenced a chromosome-level genome, multi-tissue transcriptomes, and population genomic data for the Atlantic Halibut (<i>Hippoglossus hippoglossus</i>), which<i> </i>has an XY/XX sex determination mechanism and has recently diverged from the Pacific Halibut (<i>Hippoglossus stenolepis</i>), which has a ZZ/ZW system. We used frequency and coverage-based population genomic approaches to identify a putative sex-determining factor, <i>GSDF</i>. We characterized regions with elevated heterozygosity and linkage disequilibrium indicating suppression of recombination across a recently formed sex chromosome. We detected testis-specific expression of <i>GSDF</i>, the sequence for which was highly conserved across flatfish. Based on evidence from genome-wide association, coverage, linkage disequilibrium, testis and brain transcriptomes, and sequence conservation with other flatfish, we propose a mechanism for the recent evolution of an XY sex-determination mechanism in Atlantic Halibut. A loss of function of the ancestral sex-determining gene <i>DMRT1</i> in regulating the downstream gene <i>GSDF</i> likely enabled <i>GSDF, </i>or a proximal regulatory element, to become the primary sex-determining factor. Our results suggest changes to a small number of elements can have drastic repercussions for the genomic substrate available to sex-specific evolutionary forces, providing insight into how certain elements repeatedly evolve to control sex across taxa. Our chromosome-level assembly, multi-tissue transcriptomes, and population genomic data provide a valuable resource and understanding of the evolution of sexual systems in fishes.</p>
FIGURE 12. Hippoglossus grigorjewi. Holotype ZIN 8732 in Annotated catalogue of type specimens of flatfishes (Osteichthyes: Pleuronectiformes) in the Zoological Institute, St. Petersburg, Russia
FIGURE 12. Hippoglossus grigorjewi. Holotype ZIN 8732, photo—(A) and radiograph (B).
Hippoglossus hippoglossus SNP data for coverage-based sex association
Open the record for dataset details and reuse information.
Profiling of the embryonic Atlantic halibut (Hippoglossus hippoglossus L.) transcriptome reveals maternal transcripts as potential markers of embryo quality
GEO Series GSE61051. Hippoglossus hippoglossus. 15 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.