Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
26
datasets available to search
ShareScore release 0.9.0
Dataset results
26 results for “Histoplasma”
Phenotypic characterization of Histoplasma species
<p>Histoplasmosis is an endemic mycosis that often presents as a respiratory infection in immunocompromised patients. Hundreds of thousands of new infections are reported annually around the world. The etiological agent of the disease, <em>Histoplasma, </em>is a dimorphic fungus commonly found in the soil where it grows as mycelia. Humans can become infected by <em>Histoplasma</em> through inhalation of its spores (conidia) or mycelial particles. The fungi transitions into the yeast phase in the lungs at 37°C. Once in the lungs, yeast cells reside and proliferate inside alveolar macrophages. Genomic work has revealed that <em>Histoplasma</em> is composed of at least five cryptic phylogenetic species that differ genetically. Three of those lineages have received new names. Here we evaluated multiple phenotypic characteristics (colony morphology, secreted proteolytic activity, yeast size and growth rate) of strains from five of the phylogenetic species of <em>Histoplasma</em> to identify phenotypic traits that differentiate between these species: <em>H. capsulatum</em> <em>sensu stricto</em>, <em>H. ohiense</em>, <em>H. mississippiense</em>, <em>H. suramericanum</em>, and an African lineage. We report diagnostic traits for three species. The other two species can be identified by a combination of traits. Our results suggest that 1) there are significant phenotypic differences among the cryptic species of <em>Histoplasma</em>, and 2) that those differences can be used to positively distinguish those species in a clinical setting and for further study of the evolution of this fungal pathogen.</p>
Phenotypic characterization of Histoplasma species
Open the record for dataset details and reuse information.
Data from: Genome sequences reveal cryptic speciation in the human pathogen Histoplasma capsulatum
Histoplasma capsulatum is a pathogenic fungus that causes life-threatening lung infections. About 500,000 people are exposed to H. capsulatum each year in the United States, and over 60% of the U.S. population has been exposed to the fungus at some point in their life. We performed genome-wide population genetics and phylogenetic analyses with 30 Histoplasma isolates representing four recognized areas where histoplasmosis is endemic and show that the Histoplasma genus is composed of at least four species that are genetically isolated and rarely interbreed. Therefore, we propose a taxonomic rearrangement of the genus. IMPORTANCE: The evolutionary processes that give rise to new pathogen lineages are critical to our understanding of how they adapt to new environments and how frequently they exchange genes with each other. The fungal pathogen Histoplasma capsulatum provides opportunities to precisely test hypotheses about the origin of new genetic variation. We find that H. capsulatum is composed of at least four different cryptic species that differ genetically and also in virulence. These results have implications for the epidemiology of histoplasmosis because not all Histoplasma species are equivalent in their geographic range and ability to cause disease.
Data from: Genome sequences reveal cryptic speciation in the human pathogen Histoplasma capsulatum
Open the record for dataset details and reuse information.
Genome-wide reprogramming of transcript architecture by temperature specifies the developmental states of the human pathogen Histoplasma [transcriptional profiling]
GEO Series GSE68706. Histoplasma capsulatum. 16 samples. Type: Expression profiling by high throughput sequencing.
Rapid gain and loss of a chromosome drives key morphology and virulence phenotypes in Histoplasma, a fungal pathogen of humans
GEO Series GSE296938. Histoplasma ohiense. 57 samples. Type: Expression profiling by high throughput sequencing.
The Rpd3 histone deacetylase is critical for temperature-mediated morphogenesis and virulence in the human fungal pathogen Histoplasma -- HDACi RNA-seq
GEO Series GSE315800. Histoplasma ohiense. 24 samples. Type: Expression profiling by high throughput sequencing.
The Rpd3 histone deacetylase is critical for temperature-mediated morphogenesis and virulence in the human fungal pathogen Histoplasma – HDACi histone acetyl ChIP-seq (SE)
GEO Series GSE316185. Histoplasma ohiense. 18 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The Rpd3 histone deacetylase is critical for temperature-mediated morphogenesis and virulence in the human fungal pathogen Histoplasma – HDACi histone acetyl ChIP-seq (PE)
GEO Series GSE316386. Histoplasma ohiense. 36 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The Rpd3 histone deacetylase is critical for temperature-mediated morphogenesis and virulence in the human fungal pathogen Histoplasma – HDAC mutant histone acetyl ChIP-seq
GEO Series GSE316355. Histoplasma ohiense. 24 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Transcriptional profiling of yeast to hyphae and hyphae to yeast transitions for Histoplasma strains differing in chromosome copy number.
GEO Series GSE296936. Histoplasma ohiense. 36 samples. Type: Expression profiling by high throughput sequencing.
The Rpd3 histone deacetylase is critical for temperature-mediated morphogenesis and virulence in the human fungal pathogen Histoplasma – HDAC mutant RNA-seq
GEO Series GSE315932. Histoplasma ohiense. 18 samples. Type: Expression profiling by high throughput sequencing.
The Rpd3 histone deacetylase is critical for temperature-mediated morphogenesis and virulence in the human fungal pathogen Histoplasma – HDAC mutant TF ChIP-seq
GEO Series GSE316184. Histoplasma ohiense. 24 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The Rpd3 histone deacetylase is critical for temperature-mediated morphogenesis and virulence in the human fungal pathogen Histoplasma – HDACi TF ChIP-seq
GEO Series GSE316014. Histoplasma ohiense. 24 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The Rpd3 histone deacetylase is critical for temperature-mediated morphogenesis and virulence in the human fungal pathogen Histoplasma
GEO Series GSE316691. Histoplasma ohiense. 150 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Genome-wide reprogramming of transcript architecture by temperature specifies the developmental states of the human pathogen Histoplasma [ribosome profiling]
GEO Series GSE68705. Histoplasma capsulatum. 8 samples. Type: Expression profiling by high throughput sequencing; Other.
Expression profiling of Histoplasma capsulatum G217B yeast to filament transition in GlcNAc or glucose for wild type, msb2, and complemented strains
GEO Series GSE124292. Histoplasma ohiense. 87 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide reprogramming of transcript architecture by temperature specifies the developmental states of the human pathogen Histoplasma
GEO Series GSE68707. Histoplasma capsulatum. 24 samples. Type: Expression profiling by high throughput sequencing; Other.
Comparative transcriptomics of infectious spores from the fungal pathogen Histoplasma capsulatum
GEO Series GSE45432. Histoplasma capsulatum. 15 samples. Type: Expression profiling by array.
Experimental annotation of Histoplasma capsulatum transcribed regions using high-resolution tiling arrays
GEO Series GSE31155. Histoplasma capsulatum. 93 samples. Type: Expression profiling by genome tiling array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.