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11 results for “Histoplasma capsulatum”
Data from: Genome sequences reveal cryptic speciation in the human pathogen Histoplasma capsulatum
Histoplasma capsulatum is a pathogenic fungus that causes life-threatening lung infections. About 500,000 people are exposed to H. capsulatum each year in the United States, and over 60% of the U.S. population has been exposed to the fungus at some point in their life. We performed genome-wide population genetics and phylogenetic analyses with 30 Histoplasma isolates representing four recognized areas where histoplasmosis is endemic and show that the Histoplasma genus is composed of at least four species that are genetically isolated and rarely interbreed. Therefore, we propose a taxonomic rearrangement of the genus. IMPORTANCE: The evolutionary processes that give rise to new pathogen lineages are critical to our understanding of how they adapt to new environments and how frequently they exchange genes with each other. The fungal pathogen Histoplasma capsulatum provides opportunities to precisely test hypotheses about the origin of new genetic variation. We find that H. capsulatum is composed of at least four different cryptic species that differ genetically and also in virulence. These results have implications for the epidemiology of histoplasmosis because not all Histoplasma species are equivalent in their geographic range and ability to cause disease.
Data from: Genome sequences reveal cryptic speciation in the human pathogen Histoplasma capsulatum
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Expression profiling of Histoplasma capsulatum G217B yeast to filament transition in GlcNAc or glucose for wild type, msb2, and complemented strains
GEO Series GSE124292. Histoplasma ohiense. 87 samples. Type: Expression profiling by high throughput sequencing.
Comparative transcriptomics of infectious spores from the fungal pathogen Histoplasma capsulatum
GEO Series GSE45432. Histoplasma capsulatum. 15 samples. Type: Expression profiling by array.
Experimental annotation of Histoplasma capsulatum transcribed regions using high-resolution tiling arrays
GEO Series GSE31155. Histoplasma capsulatum. 93 samples. Type: Expression profiling by genome tiling array.
SRE1 Regulates Iron-Dependent Gene Expression in the Fungal Pathogen Histoplasma capsulatum
GEO Series GSE33792. Histoplasma capsulatum. 20 samples. Type: Expression profiling by array.
The Histoplasma capsulatum virulence factor CBP1 mediates a unique transcriptional signature associated with host-cell lysis
GEO Series GSE23378. Mus musculus. 64 samples. Type: Expression profiling by array.
Comparative transcriptomics of infectious spores from the fungal pathogen Histoplasma capsulatum G217B
GEO Series GSE45415. Histoplasma capsulatum. 8 samples. Type: Expression profiling by array.
Conidia but not yeast cells of the fungal pathogen Histoplasma capsulatum trigger a type I interferon innate immune response in murine macrophages
GEO Series GSE20022. Mus musculus. 24 samples. Type: Expression profiling by array.
Apoptosis pathway analysis of genes from macropahges infected with Histoplasma capsulatum
GEO Series GSE32965. Mus musculus. 15 samples. Type: Expression profiling by RT-PCR.
Comparative transcriptomics of infectious spores from the fungal pathogen Histoplasma capsulatum G186AR
GEO Series GSE45416. Histoplasma capsulatum. 7 samples. Type: Expression profiling by array.
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.