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56 results for “Homeodomain”
Data from: Ancient mechanisms for the evolution of the bicoid homeodomain's function in fly development
The ancient mechanisms that caused developmental gene regulatory networks to diversify among distantly related taxa are not well understood. Here we use ancestral protein reconstruction, biochemical experiments, and developmental assays of transgenic animals carrying reconstructed ancestral genes to investigate how the transcription factor Bicoid (Bcd) evolved its central role in anterior-posterior patterning in flies. We show that most of Bcd's derived functions are attributable to evolutionary changes within its homeodomain (HD) during a phylogenetic interval >140 million years ago. A single substitution from this period (Q50K) accounts almost entirely for the evolution of Bcd's derived DNA specificity in vitro. In transgenic embryos expressing the reconstructed ancestral HD, however, Q50K confers activation of only a few of Bcd's transcriptional targets and yields a very partial rescue of anterior development Adding a second historical substitution (M54R) confers regulation of additional Bcd targets and further rescues anterior development. These results suggest that two epistatically interacting mutations played a major role in the evolution of Bcd's controlling regulatory role in early development.
The underground life of homeodomain-leucine zipper transcription factors
<p class="western"><span>Roots are the anchorage organs of plants, responsible for water and nutrient uptake, exhibiting high plasticity. Root architecture is driven by the interactions of biomolecules, including transcription factors (TFs) and hormones that are crucial players regulating root plasticity. Multiple TF families are involved in root development; some, such as ARFs and LBDs, have been well characterized, whereas others remain less investigated. In this review, we synthesize the current knowledge about the involvement of the large family of homeodomain-leucine zipper (HD-Zip) TFs in root development. This family is divided into four subfamilies (I to IV), mainly according to structural features, such as additional motifs aside from HD-Zip, as well as their size, gene structure, and expression patterns. We explored and analyzed public databases and the scientific literature regarding HD-Zip TFs in Arabidopsis and other species. Most members of the four HD-Zip subfamilies are expressed in specific cell types and several ones from each group have assigned functions in root development. Notably, a high proportion of the studied proteins are part of intricate regulation pathways involved in primary and lateral root growth and development.</span></p>
The underground life of homeodomain-leucine zipper transcription factors
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Data from: Ancient mechanisms for the evolution of the bicoid homeodomain's function in fly development
Open the record for dataset details and reuse information.
Aberrant homeodomain-DNA cooperative dimerization underlies distinct developmental defects in two dominant CRX retinopathy models [MPRA]
GEO Series GSE256214. Mus musculus. 6 samples. Type: Other.
Aberrant homeodomain-DNA cooperative dimerization underlies distinct developmental defects in two dominant CRX retinopathy models
GEO Series GSE256215. synthetic construct; Mus musculus. 32 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other.
The LIM homeodomain transcription factor Lhx2 is required for Müller glia development in the vertebrate retina.
GEO Series GSE75889. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
A family of double-homeodomain transcription factors promotes zygotic genome activation in placental mammals [ChIP-seq_d2]
GEO Series GSE94323. Mus musculus. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Exploring the DNA-Recognition Potential of Homeodomains
GEO Series GSE35806. synthetic construct. 249 samples. Type: Other.
Homeodomain-only protein (HOPX) negatively regulates CD8+ T cell proliferation and affects differentiation and aging
GEO Series GSE234697. Homo sapiens. 8 samples. Type: Expression profiling by array.
Missense mutations in CRX homeodomain cause dominant retinopathies through two distinct mechanisms [Spec-seq]
GEO Series GSE223658. synthetic construct. 16 samples. Type: Other.
Homeodomain-containing protein PRRX1 senses DNA double-strand breaks and anchors the Ku heterodimers to promote non-homologous end-joining
GEO Series GSE265857. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Missense mutations in CRX homeodomain cause dominant retinopathies through two distinct mechanisms [RNA-seq]
GEO Series GSE223439. Mus musculus. 36 samples. Type: Expression profiling by high throughput sequencing.
Aberrant homeodomain-DNA cooperative dimerization underlies distinct developmental defects in two dominant CRX retinopathy models [Coop-seq]
GEO Series GSE256213. synthetic construct. 8 samples. Type: Other.
Transcriptional Dominance of Pax7 in Adult Myogenesis Is Due to High-Affinity Recognition of Homeodomain Motifs
GEO Series GSE25092. Mus musculus. 12 samples. Type: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing.
A family of double-homeodomain transcription factors promotes zygotic genome activation in placental mammals.
GEO Series GSE94325. Homo sapiens; Mus musculus. 32 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Evolution of antagonism among DUX family members from an ancestral toxic single homeodomain protein I
GEO Series GSE214228. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Inhibition of the multifunctional homeodomain-interacting protein kinase 2 (HIPK2) alleviates thoracic aortic disease in mice with progressively severe Marfan syndrome
GEO Series GSE145903. Mus musculus; Homo sapiens. 14 samples. Type: Expression profiling by high throughput sequencing.
Context-dependent gene regulation by homeodomain transcription factor complexes revealed by shape-readout deficient proteins
GEO Series GSE125604. Drosophila melanogaster. 33 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other; Expression profiling by high throughput sequencing.
A family of double-homeodomain transcription factors promotes zygotic genome activation in placental mammals [ChIP-seq_d1]
GEO Series GSE94322. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
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