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40 results for “Human Leukocyte Antigen”
Data for: Endo-lysosomal assembly variations among Human Leukocyte Antigen class I (HLA-I) allotypes
<p>The extreme polymorphisms of HLA-I proteins enable the presentation of diverse peptides to cytotoxic T lymphocytes (CTL). The canonical endoplasmic reticulum (ER) HLA-I assembly pathway enables presentation of cytosolic peptides, but effective intracellular surveillance requires multi-compartmental antigen sampling. Endo-lysosomes are generally sites of HLA class II assembly, but human monocytes and monocyte-derived dendritic cells (moDCs) also contain significant reserves of endo-lysosomal HLA-I molecules. We hypothesized variable influences of HLA-I polymorphisms upon outcomes of endo-lysosomal trafficking, as the stabilities and peptide occupancies of cell surface HLA-I are variable. Consistent with this model, when the endo-lysosomal pH of moDCs is disrupted, HLA-B allotypes display varying propensities for reductions in surface expression, with HLA-B*08:01 or HLA-B*35:01 being among the most resistant or sensitive respectively, among eight tested HLA-B allotypes. Perturbations of moDC endo-lysosomal pH result in redistribution of HLA-B*35:01, but not HLA-B*08:01, to LAMP1+ compartments and increase HLA-B*35:01 peptide receptivity. These findings reveal the intersection of the vacuolar cross-presentation pathway with a constitutive assembly pathway for some HLA-B allotypes. Notably, cross-presentation of epitopes derived from two soluble antigens was also more efficient for B*35:01 compared to B*08:01, even when matched for T cell response sensitivity, and more affected by cathepsin inhibition. Thus, HLA-I polymorphisms dictate the degree of endo-lysosomal assembly, which can supplement ER assembly for constitutive HLA-I expression and increase the efficiency of cross-presentation.</p>
Comparison of Tacrolimus Extended-Release (Envarsus XR) to Tacrolimus Immediate-Release in Human Leukocyte Antigen (HLA) Sensitized Kidney Transplant Recipients
ClinicalTrials.gov study NCT04225988. IPD Sharing: NO. Countries: 1. Publications: 9.
Effects of Mycophenolate Mofetil (MMF) On Anti-HLA (Human Leukocyte Antigen)Antibody Levels In Patients Awaiting Cadaveric Renal Transplant.
ClinicalTrials.gov study NCT00446459. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Human Leukocyte Antigen-A*02:01-restricted Tumor Vessel Specific Peptide Vaccination for Advanced Pancreatic Cancer
ClinicalTrials.gov study NCT00683085. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Study to Learn How Safe and Tolerable Vonsetamig is in Adult Patients With Chronic Kidney Disease (CKD) Who Need Kidney Transplantation and Are Highly Sensitized to Human Leukocyte Antigen (HLA)
ClinicalTrials.gov study NCT05092347. IPD Sharing: YES. Countries: 1. Publications: 0.
Data for: Endo-lysosomal assembly variations among Human Leukocyte Antigen class I (HLA-I) allotypes
Open the record for dataset details and reuse information.
Human Leukocyte Antigen (HLA) - A*2402 Restricted Peptide Vaccine Therapy in Patients With Advanced Gastric Cancer
ClinicalTrials.gov study NCT00845611. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Most Closely Human Leukocyte Antigen (HLA)-Matched Adenovirus-specific T Lymphocytes (Viralym-A)
ClinicalTrials.gov study NCT02276820. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Early Human Leukocyte Antigen (HLA) Matched Sibling Hematopoietic Stem Cell Transplantation
ClinicalTrials.gov study NCT04018937. IPD Sharing: NO. Countries: 2. Publications: 1.
Human Leukocyte Antigen-A*2402-Restricted Tumor Vessel Specific Peptide Vaccination for Advanced Pancreatic Cancer
ClinicalTrials.gov study NCT00683358. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Most Closely Human Leukocyte Antigen (HLA)-Matched BK Virus-specific T Lymphocytes (Viralym-B)
ClinicalTrials.gov study NCT02313844. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Most Closely Human Leukocyte Antigen (HLA)-Matched CMV-specific T Lymphocytes (Viralym-C)
ClinicalTrials.gov study NCT02313857. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Human Leukocyte Antigen (HLA) Class I Haplotype Mismatched Natural Killer Cell Infusions
ClinicalTrials.gov study NCT00660166. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Human Leukocyte Antigen (HLA)-Haploidentical Hematopoietic Stem Cell Transplantation for Patients With Aplastic Anemia
ClinicalTrials.gov study NCT01105273. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Trial to Evaluate Safety and Tolerability of Tacrolimus Extended-Release (Astagraf XL) in Human Leukocyte Antigen (HLA) Sensitized Kidney Transplant Recipients
ClinicalTrials.gov study NCT03194321. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Epigenome-wide and Transcriptome-wide Analyses Reveal Gestational Diabetes is Associated with Alterations in the Human Leukocyte Antigen Complex [methylation]
GEO Series GSE70453. Homo sapiens. 82 samples. Type: Methylation profiling by array.
Human Leukocyte Antigen Class II (DRB1 and DQB1) Alleles and Haplotypes Frequencies in Patients With Pemphigus Vulgaris Among the Russian Population
ClinicalTrials.gov study NCT05284929. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of Human Leukocyte Antigen (HLA) Polymorphisms in Patients With Rheumatoid Arthritis
ClinicalTrials.gov study NCT01111357. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Trial of Nivolumab Following Partially Human Leukocyte Antigen (HLA) Mismatched BMT in Children & Adults With Sarcoma
ClinicalTrials.gov study NCT03465592. IPD Sharing: NO. Countries: 1. Publications: 0.
Evaluation of Cyto-chex Tubes for the Measurement of Monocyte Expression of Human Leukocyte Antigen - DR Isotype (HLA-DR) Molecules by Flow Cytometry
ClinicalTrials.gov study NCT05546632. IPD Sharing: NO. Countries: 1. Publications: 0.
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