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472 results for “Hyaluronic acid”
"The pathway of hyaluronic acid (HA) and its receptors (CD44, RHAMM) in the regulation of Rho GTPases and their effectors in an in vitro colorectal cancer model" ("Szlak kwasu hialuronowego (HA) i jego receptorów (CD44, RHAMM) w regulacji GTPaz Rho i ich efektorów w modelu raka jelita grubego in vitro"); NCN Miniatura 2022/06/X/NZ3/00848
<p>Results from Screening for "The pathway of hyaluronic acid (HA) and its receptors (CD44, RHAMM) in the regulation of Rho GTPases and their effectors in an in vitro colorectal cancer model" the project <strong>Miniatura</strong> (<strong>2022/06/X/NZ3/00848</strong>) funded by Polish <strong>National Science Centre (NCN)</strong></p> <p>Wyniki skriningu w projekcie "Szlak kwasu hialuronowego (HA) i jego receptorów (CD44, RHAMM) w regulacji GTPaz Rho i ich efektorów w modelu raka jelita grubego in vitro", <strong>Miniatura</strong> (<strong>2022/06/X/NZ3/00848</strong>) finansowanym przez <strong>Narodowe Centrum Nauki (NCN)</strong></p>
Data from: Sustained neurotrophin-3 delivery from hyaluronic acid hydrogels for neural tissue regeneration
<p>The goal of this work was to design a polymer-based platform capable of localized, long-term delivery of biologically active neurotropic factors using an affinity-based approach. Here, we synthesized hyaluronic acid-methylfuran (HA-mF) hydrogels that provide sustained, affinity-based release of neurotrophin-3 (NT-3), a growth factor that promotes axon growth for 28 days. A Diels-Alder crosslinking reaction between HA-mF and polyethylene glycol (PEG)-dimaleimide occurs within 15 minutes under physiological conditions, resulting in injectable hydrogels that can be polymerized in the presence of cells and growth factors. We also tuned the hydrogel's storage modulus to match that of native rat spinal cord tissue, providing a platform not only for localized drug delivery but also a suitable vehicle for cellular transplantation. The NT-3 released from the HAmF hydrogels remains bioactive for at least 14 days, promoting axonal growth from primary sensory neurons as well as stem cell-derived V2a interneurons and motoneurons <em>in vitro</em>. The hydrogels also supported cell growth allowing for 3-dimensional axonal extensions within the scaffold matrix. Here we confirm the protective role of HA-mF on matrix-bound NT-3 activity and show that these hydrogels are an excellent platform for drug delivery for neural applications.</p>
Effect of Injectable Hyaluronic Acid (HYADENT BG (HA)) on Bone Healing in Extraction Sockets
ClinicalTrials.gov study NCT07318298. IPD Sharing: NO. Countries: 1. Publications: 1.
Hyaluronic Acid in Overuse Knee Pain
ClinicalTrials.gov study NCT05450458. IPD Sharing: NO. Countries: 1. Publications: 34.
Effectiveness of PRP, Conditioned Medium UC-MSCs Secretome and Hyaluronic Acid for the Treatment of Knee Osteoarthritis
ClinicalTrials.gov study NCT05579665. IPD Sharing: NO. Countries: 1. Publications: 6.
A Randomized, Single Center Pilot Study Comparing Hyaluronic Acid to Vaginal Estrogen for Treatment of Genitourinary Syndrome of Menopause
ClinicalTrials.gov study NCT04544475. IPD Sharing: YES. Countries: 1. Publications: 1.
Platelet Rich Plasma vs Hyaluronic-Acid in Hip OA (Osteoarthritis)
ClinicalTrials.gov study NCT01920152. IPD Sharing: Not stated. Countries: 1. Publications: 6.
A Double Blind Study Comparing Hyaluronic Acid, Corticosteroid and Placebo During Arthrocentesis for Temporomandibular Joint (TMJ) Dysfunction
ClinicalTrials.gov study NCT01524913. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Hyaluronic Acid vs Platelet Rich Plasma: Effects on Clinical Outcomes and Intra-articular Biology for the Treatment of Knee Osteoarthritis
ClinicalTrials.gov study NCT02588872. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Single vs Triple Hyaluronic Acid in Knee Osteoarthritis
ClinicalTrials.gov study NCT07352540. IPD Sharing: NO. Countries: 0. Publications: 2.
Cooled Radiofrequency vs. Hyaluronic Acid to Manage Knee Pain
ClinicalTrials.gov study NCT03381248. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Polynucleotide and Hyaluronic Acid-based Gel as Adjunctive Therapy to Non- Surgical Treatment of Intraosseous Peri-implant Defect. A Randomized Clinical Trial
ClinicalTrials.gov study NCT06914518. IPD Sharing: NO. Countries: 1. Publications: 7.
Impact of Nipple Reconstruction in Mastectomized Patients Using Cross-Linked Hyaluronic Acid Injection.
ClinicalTrials.gov study NCT07008339. IPD Sharing: YES. Countries: 1. Publications: 18.
Comparative Study of Safety and Efficacy of Two Hyaluronic Acids for the Treatment of Knee Osteoarthritis Pain
ClinicalTrials.gov study NCT01295580. IPD Sharing: NO. Countries: 1. Publications: 1.
Effects on the Pain of an Infiltration by Acid Hyaluronic Association and Corticoids Versus Only Corticoids in the Rhizarthrosis.
ClinicalTrials.gov study NCT03431584. IPD Sharing: NO. Countries: 1. Publications: 2.
Data from: Sustained neurotrophin-3 delivery from hyaluronic acid hydrogels for neural tissue regeneration
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Figure S1. Tear break-up time value in hyaluronic acid (HA) group and non-HA group after excluding the source of publication bias
<p>Figure S1. Tear break-up time value in hyaluronic acid (HA) group and non-HA group after excluding the source of publication bias <br> </p>
Effects of a combination of polynucleotide and hyaluronic acid for treating osteoarthritis
<p><span>(A) Safranin O-Fast Green Staining. (B) OARSI score and grade in tibia and femur. n = 10 – 12 per group. Sham, sham operation; OA, osteoarthritis; </span><span>Cont</span><span>, control vehicle; PNHA/b, polynucleotide (2%) with hyaluronic acid (0.5%); HA, hyaluronic acid (0.5%). Relative to OA control: *p < 0.05, **p < 0.01, ***p < 0.0001 (unpaired t-test). The data are expressed as the mean ± SEM.</span></p>
Schiff Base Crosslinked Hyaluronic Acid Hydrogels with Tunable and Cell Instructive Time-Dependent Mechanical Properties
<p>This folder contains raw data for the paper titled "<strong>Schiff Base Crosslinked Hyaluronic Acid Hydrogels</strong><strong> with Tunable and Cell Instructive Time-Dependent Mechanical Properties</strong>" authored by Taha Behroozi Kohlan, Yanru Wen, Carina Milena Mini, and Anna Finne-Wistrand, published in <em>Carbohydrate Polymers</em> journal. The raw data presented here contains NMR, FTIR, SEC, swelling and stability, and rheology data used to create figures.</p> <p><strong>Abstract:</strong></p> <p>The dynamic interplay between cells and their native extracellular matrix (ECM) influences cellular behavior, imposing a challenge in biomaterial design. Dynamic covalent hydrogels are viscoelastic and show self-healing ability, making them a potential scaffold for recapitulating native ECM properties. We aimed to implement kinetically and thermodynamically distinct crosslinkers to prepare self-healing dynamic hydrogels to explore the arising properties and their effects on cellular behavior. To do so, aldehyde-substituted hyaluronic acid (HA) was synthesized to generate imine, hydrazone, and oxime crosslinked dynamic covalent hydrogels. Differences in equilibrium constants of these bonds yielded distinct properties including stiffness, stress relaxation, and self-healing ability. The effects of degree of substitution (DS), polymer concentration, crosslinker to aldehyde ratio, and crosslinker functionality on hydrogel properties were evaluated. The self-healing ability of hydrogels was investigated on samples of the same and different crosslinkers and DS to obtain hydrogels with gradient properties. Subsequently, human dermal fibroblasts were cultured in 2D and 3D to assess the cellular response considering the dynamic properties of the hydrogels. Moreover, assessing cell spreading and morphology on hydrogels having similar modulus but different stress relaxation rates showed the effects of matrix viscoelasticity with higher cell spreading in slower relaxing hydrogels.</p>
Dataset_Ultrasound guided hip injections with high density hyaluronic acid: outcome at one year follow up.
<p><span>The ultrasound-guided viscosupplementation of the hip joint with hyaluronic acid (HA) is considered a standard procedure among the conservative treatments for hip arthritis. The aim of this study was to evaluate the clinical benefit and the incidence of adverse events of the technique in an observational study at one year follow up. Methods:<span>We</span><strong><span> </span></strong><span>evaluated a consecutive series of 85 patients with a diagnosis of symptomatic arthritis who underwent intra-articular ultrasound-guided hyaluronic acid injections. The scales used for evaluation were </span></span><span>modified Harris Hip Score (mHHS), WOMAC</span><span>, and </span><span>Hip Outcome Score (HOS) with subscale Sport (HOSs), for pain the Visual Analogic Scale (VAS). The patients were classified according to Tonnis’ radiological classification of arthritis (range 0–3): 20 patients (grade 0), 32 (grade 1), 18 (grade 2), 15 (grade 3). Results:At last follow up, all the scales</span><span> increased: mHHS from 59.35 to 82.1, HOS from 69.45 to 78.53, HOss from 47.4 to 58.11, VAS from 6.09 to 3.97, WOMAC from 33.2 to 31.5 (<em>p </em><<em> </em>0.05 for all the parameters); the results were elaborated with GraphPad Prism v5.0 (Prism Software La Jolla, CA, USA) using Wilcoxon’s test. A total of </span><span>13 patients out of 85 needed arthroplasty, all classified as Tonnis grade 3.</span><span> No serious adverse events were noted due to the procedure.Conclusion:</span><span> <span>Based</span><strong> </strong>on our findings, indication for the use of hyaluronic acid is limited to patients with mild to moderate arthritis. Patients in advanced arthritis refusing replacement surgery and asking for this treatment should be informed about the poor results of the technique even in the short term.</span></p>
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