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273 results for “Hyperglycemia”
Single-cell transcriptomic profiling unveils dysregulation of cardiac progenitor cells and cardiomyocytes in a mouse model of maternal hyperglycemia
<p>Congenital heart disease (CHD) is the most prevalent structural malformations of the heart affecting ∼1% of live births. To date, both damaging genetic variations and adverse environmental exposure such as maternal diabetes have been found to cause CHD. Clinical studies show ∼fivefold higher risk of CHD in the offspring of mothers with pregestational diabetes. Maternal pregestational diabetes affects the gene regulatory networks key to proper cardiac development in the fetus. However, the cell-type specificity of these gene regulatory responses to maternal diabetes and their association with the observed cardiac defects in the fetuses remains unknown. To uncover the transcriptional responses to maternal diabetes in the early embryonic heart, we used an established murine model of pregestational diabetes. In this model, we have previously demonstrated an increased incidence of CHD. Here, we show maternal hyperglycemia (matHG) elicits diverse cellular responses during heart development by single-cell RNA-sequencing in embryonic hearts exposed to control and matHG environment. Through differential gene-expression and pseudotime trajectory analyses of this data, we identified changes in lineage specifying transcription factors, predominantly affecting Isl1+ second heart field progenitors and Tnnt2+cardiomyocytes with matHG. Using in vivo cell-lineage tracing studies, we confirmed that matHG exposure leads to impaired second heart field-derived cardiomyocyte differentiation. Finally, this work identifies matHG-mediated transcriptional determinants in cardiac cell lineages elevate CHD risk and show perturbations in Isl1-dependent gene-regulatory network (Isl1-GRN) affect cardiomyocyte differentiation. Functional analysis of this GRN in cardiac progenitor cells will provide further mechanistic insights into matHG-induced severity of CHD associated with diabetic pregnancies.</p>
Hyperglycemia and steroid use increase the risk of rhino-orbito-cerebral mucormycosis regardless of COVID-19 hospitalization: Case-control study, India
<p><strong>Abstract</strong></p> <p><strong><em>BACKGROUND</em></strong></p> <p>In the context of the ongoing COVID-19 pandemic increased incidence of ROCM was noted in India, among those infected with COVID. We determined risk factors for rhino-orbito-cerebral mucormycosis (ROCM) post Coronavirus disease 2019 (COVID-19) among those never and ever hospitalized for COVID-19 separately through a multi-centric, hospital-based, unmatched case-control study across India.</p> <p><strong><em>METHODS</em></strong></p> <p>We defined cases and controls as those with and without post-COVID ROCM, respectively. We compared their socio-demographics, comorbidities, steroid use, glycaemic status, and practices. We calculated crude and adjusted odds ratio (AOR) with 95% confidence intervals (CI) through logistic regression. The covariates with p-value for crude OR of less 0·20 were considered for the regression model.</p> <p><strong><em>RESULTS</em></strong></p> <p>Among hospitalised, we recruited 267 cases and 256 controls and 116 cases and 231 controls among never hospitalised. Risk factors (AOR; 95% CI) for post-COVID ROCM among the hospitalised were age 45-59 years (2·1; 1·4 to 3·1), having diabetes mellitus (4·9; 3·4 to 7·1), elevated plasma glucose (6·4; 2·4 to 17·2), steroid use (3·2; 2 to 5·2) and frequent nasal washing (4·8; 1·4 to 17). Among those never hospitalised, age ≥ 60 years (6·6; 3·3 to 13·3), having diabetes mellitus (6·7; 3·8 to 11·6), elevated plasma glucose (13·7; 2·2 to 84), steroid use (9·8; 5·8 to 16·6), and cloth facemask use (2·6; 1·5 to 4·5) were associated with increased risk of post-COVID ROCM.</p> <p><strong><em>CONCLUSIONS</em></strong></p> <p>Hyperglycemia irrespective of having diabetes mellitus and steroid use was associated with increased risk of ROCM independent of COVID-19 hospitalisation. Rational steroid usage and glucose monitoring may reduce the risk of post-COVID.</p>
Study of Management of Pasireotide-induced Hyperglycemia in Adult Patients With Cushing's Disease or Acromegaly
ClinicalTrials.gov study NCT02060383. IPD Sharing: YES. Countries: 12. Publications: 2.
Hyperglycemia in Renal Transplantation
ClinicalTrials.gov study NCT01643382. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Green Tea Confections For Managing Postprandial Hyperglycemia-Induced Vascular Endothelial Dysfunction
ClinicalTrials.gov study NCT01857258. IPD Sharing: YES. Countries: 1. Publications: 1.
Insulin for Hyperglycemia in Stroke Trial
ClinicalTrials.gov study NCT04834362. IPD Sharing: NO. Countries: 1. Publications: 3.
A Study of Postprandial Hyperglycemia in Participants With Type 2 Diabetes
ClinicalTrials.gov study NCT01159938. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Effects of a Complete Diet in Critically Ill Patients With Stress Hyperglycemia
ClinicalTrials.gov study NCT01233726. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Effect of Hyperglycemia on Microvascular Perfusion in Healthy Adults
ClinicalTrials.gov study NCT03520569. IPD Sharing: NO. Countries: 1. Publications: 31.
Benefits of Insulin Supplementation for Correction of Hyperglycemia in Patients With Type 2 Diabetes
ClinicalTrials.gov study NCT02408120. IPD Sharing: NO. Countries: 1. Publications: 1.
Metformin and Transient Hyperglycemia
ClinicalTrials.gov study NCT01486043. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Golden Rice Cookies With Piper Crocatum for Blood Glucose Control and Quality of Life in People Living With HIV With Hyperglycemia
ClinicalTrials.gov study NCT07187648. IPD Sharing: NO. Countries: 0. Publications: 3.
Use of NPH Versus Basal Bolus Insulin for Steroid Induced Hyperglycemia
ClinicalTrials.gov study NCT03511521. IPD Sharing: NO. Countries: 1. Publications: 5.
Hyperglycemia and Cardiovascular Outcomes With Type 2 Diabetes
ClinicalTrials.gov study NCT00191282. IPD Sharing: Not stated. Countries: 17. Publications: 4.
Hospital Management of Hyperglycemia Study of Insulin Glargine Plus Insulin Lispro Versus Human Regular Insulin
ClinicalTrials.gov study NCT01136746. IPD Sharing: Not stated. Countries: 1. Publications: 5.
The Association Between Peri-Operative Hyperglycemia and Major Morbidity and Mortality
ClinicalTrials.gov study NCT00487162. IPD Sharing: NO. Countries: 1. Publications: 3.
Contribution of Hyperinsulinemia vs. Hyperglycemia to Insulin Resistance in Type 1 Diabetes and Maturity Onset Diabetes of the Young, Type 2 (MODY2)
ClinicalTrials.gov study NCT02971202. IPD Sharing: YES. Countries: 1. Publications: 1.
The Synergy to Control Emergency Department Hyperglycemia Program for Type 2 Diabetes
ClinicalTrials.gov study NCT02269098. IPD Sharing: NO. Countries: 1. Publications: 3.
Impact of Fenugreek Supplementation on Obesity and Hyperglycemia Among Diabetic Adults in Saudi Arabia
ClinicalTrials.gov study NCT07038577. IPD Sharing: NO. Countries: 1. Publications: 1.
Continuous Glucose Monitoring for Hyperglycemia in Critically Ill Patients
ClinicalTrials.gov study NCT05442853. IPD Sharing: NO. Countries: 1. Publications: 1.
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