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ShareScore release 0.9.0
Dataset results
26 results for “IAV”
Database for iav_serotype
<p>Sequence and metadata files for use with `iav_serotype`. With this version of the database, use iav_serotype version 0.1.2 or later.</p> <p><a href="https://github.com/mtisza1/influenza_a_serotype">https://github.com/mtisza1/influenza_a_serotype</a></p> <p>DBs/v1.25/Influenza_A_segment_info1.tsv</p> <p>DBs/v1.25/Influenza_A_segment_sequences.fna</p> <p> </p> <p>see <a href="https://github.com/mtisza1/influenza_a_serotype?tab=readme-ov-file#database-notes">database notes</a> for details</p>
RNA sequencing of sorted conducting airway epithelial cells from FGF9-overexpressing and control mouse lungs at 1 day post-infection with IAV
<p><span>Influenza A virus (IAV) preferentially infects conducting airway and alveolar epithelial cells in the lung. The outcome of these infections is impacted by the host response, including the production of various cytokines, chemokines, and growth factors. Fibroblast growth factor-9 (FGF9) is required for lung development, can display antiviral activity <em>in vitro</em>, and is upregulated in asymptomatic patients during early IAV infection. We therefore hypothesized that FGF9 would protect the lungs from respiratory virus infection and evaluated IAV pathogenesis in mice that overexpress FGF9 in club cells in the conducting airway epithelium (FGF9-OE mice). However, we found that FGF9-OE mice were highly susceptible to IAV and Sendai virus infection compared to control mice. FGF9-OE mice displayed elevated and persistent viral loads, increased expression of cytokines and chemokines, and increased numbers of infiltrating immune cells as early as 1 day post-infection (dpi). Gene expression analysis showed an elevated type I interferon (IFN) signature in the conducting airway epithelium and analysis of IAV tropism uncovered a dramatic shift in infection from the conducting airway epithelium to the alveolar epithelium in FGF9-OE lungs. These results demonstrate that FGF9 signaling primes the conducting airway epithelium to rapidly induce a localized, protective IFN and proinflammatory cytokine response during viral infection. Although this response protects the airway epithelial cells from IAV infection, it allows for early and enhanced infection of the alveolar epithelium, ultimately leading to increased morbidity and mortality. Our study illuminates a novel role for FGF9 in regulating respiratory virus infection and pathogenesis.</span></p>
RNA sequencing of sorted conducting airway epithelial cells from FGF9-overexpressing and control mouse lungs at 1 day post-infection with IAV
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The long non-coding RNA LUCAT1 is a negative feedback regulator of the Interferon Response in humans (IAV and HSV dataset)
GEO Series GSE145449. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Host response to IAV infections in human patients
GEO Series GSE101702. Homo sapiens. 159 samples. Type: Expression profiling by array.
Transcriptomic analysis in human bronchial epithelial cells after rhinovirus (RV) and influenza (IAV) virus infection for 48 hours
GEO Series GSE193164. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
m6A and YTHDF1, YTHDF2, YTHDF3 mapping of IAV RNA with PAR-CLIP and pA-m6A-seq
GEO Series GSE98033. Homo sapiens. 5 samples. Type: Non-coding RNA profiling by high throughput sequencing; Other.
Multiomics analysis unveils key biomarkers during dynamic progress of IAV infection in mice
GEO Series GSE292329. Mus musculus. 48 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome Profiling of Neutrophils from Patients Infected with IAV using RNA-seq
GEO Series GSE108807. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Airway Microfold (M) Cells Emerge in the Post-IAV Lung
GEO Series GSE244279. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Phospholipid Scramblase 1 (PLSCR1) Regulates Interferon-Lambda Receptor 1 (IFN-λR1) and IFN-λ Signaling in Influenza A Virus (IAV) Infection
GEO Series GSE307868. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Human CMV-specific vs IAV-specific CD8 T cells
GEO Series GSE171246. Homo sapiens. 8 samples. Type: Expression profiling by array.
Arhgdia regulates disease tolerance in IAV-infected epithelial cells
GEO Series GSE193160. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Investigation of ripk3-dependent IAV-induced genes
GEO Series GSE80740. Mus musculus. 24 samples. Type: Expression profiling by array.
Inhaled IAV vs Inhaled Eucalyptus for the Treatment of Nausea With Acute Migraine
ClinicalTrials.gov study NCT05175521. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Clinical Study Protocol of IAV-induced Remission Followed by Consolidation Therapy With MDCyta+Ven in ND-AML
ClinicalTrials.gov study NCT06232694. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Expression data from A549 cell line infected with influenza A virus (IAV) and treated with/without Itaconate
GEO Series GSE162260. Homo sapiens. 30 samples. Type: Expression profiling by array.
scRNA-seq analysis of CD11c+ cells from bronchoalveolar lavage fluid during the IAV (PR/8, H1N1) infection course
GEO Series GSE208294. Mus musculus. 17 samples. Type: Expression profiling by high throughput sequencing.
Effect of depletion of ATG7 on gene expression in IAV-infected A549 cells
GEO Series GSE211357. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Expression data from differentiated THP-1 (dTHP-1) cell line infected with influenza A virus (IAV) and treated with/without Itaconate
GEO Series GSE162261. Homo sapiens. 18 samples. Type: Expression profiling by array.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.