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176 results for “IDH”
Representative snapshots of imaging sequences used in transcan_IDH-mutant_LGG_radiomics analysis
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Codeletion of 1p and 19q determines distinct gene methylation and expression profiles in IDH-mutated oligodendroglial tumors _ Dataset
<p>Overall design: Genome-wide DNA methylation profiling of oligodendroglial tumors (OTs) and five non tumoral brain tissue (NTBT) samples. The Illumina Infinium Human DNA methylation 450k Beadchip was used to obtain DNA methylation profiles across approximately 450,000 CpGs in tumoral samples. Samples included 46 OTs and 5 NTBT.</p> <p>Bisulphite converted DNA from the 51 samples were hybridised to the Illumina Infinium 450k Human Methylation Beadchip</p> <p>Extracted molecule: genomic DNA</p> <p>Platform: Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)</p> <p>Label protocol: Standard Illumina Protocol</p> <p>Hybridization protocol: bisulphite converted DNA was amplified, fragmented and hybridised to Illumina Infinium Human Methylation 450K Beadchip using standard Illumina protocol</p> <p>Scan protocol: Arrays were imaged using BeadArray Reader using standard recommended Illumina scanner setting </p> <p>Data processing: BeadStudio software v3.2</p> <p>Data format: IDAT files</p>
Conjunto de dados do Índice de Desenvolvimento Humano (IDH) das microrregiões brasileiras
<p><strong>Contexto </strong></p> <p>O Índice de Desenvolvimento Humano (IDH) é um indicador criado pelo Programa das Nações Unidas para o Desenvolvimento (PNUD) em 1990.O IDH mede o desenvolvimento humano de um país com base em três dimensões principais: Longevidade, medida pela expectativa de vida ao nascer; Educação, avaliada pela média de anos de estudo da população adulta e pelos anos esperados de escolaridade para crianças em idade escolar; e Renda, medida pelo PIB per capita ajustado ao poder de compra. O IDH varia de 0 a 1, sendo que valores mais próximos de 1 indicam maior desenvolvimento humano [<a title="Constructing a generalized model of the human development index" href="https://doi.org/10.1016/j.seps.2019.100778" target="_blank" rel="noopener">1</a>]. Índice de Desenvolvimento Humano Municipal (IDHM) é uma adaptação do IDH para o contexto dos municípios brasileiros. Ele também considera as mesmas três dimensões (longevidade, educação e renda), mas utiliza indicadores específicos para refletir melhor a realidade local [<a title="Atlas do Desenvolvimento Humano no Brasil" href="http://www.atlasbrasil.org.br/" target="_blank" rel="noopener">2</a>]. O IDH para microregiões brasileiras não é obitido facilmente, sendo nescessário a disponibilidade de um conjunto de dados acessível. Nesse sentido, o objetivo desse trabalho foi construir um conjunto de dados do IDH de todas as microrregiões brasileiras.</p> <p><strong>Fonte de dados e processamento</strong></p> <p>O Índice de Desenvolvimento Humano (IDH) das microrregiões brasileiras foi calculado utilizando a linguagem R 4.4 com as funçoes <em>group_by e summarise</em> do pacote <em>dplyr</em>. Os municipios foram agrupados por microrregião e foi calculado a média dos IDH municipais. O IDHM foi adiquirido da plataforma Atlas Brasil [<a title="Atlas do Desenvolvimento Humano no Brasil" href="http://www.atlasbrasil.org.br/" target="_blank" rel="noopener">2</a>], selecionando as variáveis de IDH geral, educação, longevidade e renda com dados do censo de 2010. Os dados das microrregiões foram adiquiridos do IBGE [<a title="Divisão Regional do Brasil" href="https://www.ibge.gov.br/geociencias/cartas-e-mapas/redes-geograficas/15778-divisoes-regionais-do-brasil.html?edicao=16163" target="_blank" rel="noopener">3</a>] e tratados no Microssoft Excel.</p> <p><strong>Descrição dos dados</strong></p> <p>São fornecidos dois arquivos. O IDHM.xlsx corresponde ao IDH municipal e o IDH_microrregioes.xlsx correponde aos dados de IDH das microrregoes brasileiras.</p> <table> <tbody> <tr> <td><strong>Variáveis</strong></td> <td><strong>Descrição</strong></td> <td><strong>Tipo<br></strong></td> </tr> <tr> <td>CD_MICRO</td> <td>Código IBGE da microrregião</td> <td>inteiro</td> </tr> <tr> <td>MICROR</td> <td>Nome da micrrorregião</td> <td>texto</td> </tr> <tr> <td>UF</td> <td>Sigla da Unidade Federativa</td> <td>texto</td> </tr> <tr> <td>IDH</td> <td>IDH geral</td> <td>decimal</td> </tr> <tr> <td>IDH_E</td> <td>IDH de educação</td> <td>decimal</td> </tr> <tr> <td>IDH_L</td> <td>IDH de longevidade</td> <td>decimal</td> </tr> <tr> <td>IDH_</td> <td>IDH de renda</td> <td>decimal</td> </tr> </tbody> </table>
A Study to Assess the Safety and Efficacy of Two Combinations of Isocitrate Dehydrogenase (IDH) Mutant Targeted Therapies Plus Azacitidine in Participants With Newly Diagnosed Acute Myeloid Leukemia (
ClinicalTrials.gov study NCT02677922. IPD Sharing: Not stated. Countries: 14. Publications: 4.
Efficacy of Nivolumab for Recurrent IDH Mutated High-Grade Gliomas
ClinicalTrials.gov study NCT03925246. IPD Sharing: YES. Countries: 1. Publications: 1.
Nivolumab for Recurrent or Progressive IDH Mutant Gliomas
ClinicalTrials.gov study NCT03557359. IPD Sharing: UNDECIDED. Countries: 1. Publications: 8.
Imaging mass cytometry data from IDH wildtype glioblastomas
<p>Myeloid cells are highly prevalent in glioblastoma (GBM), existing in a spectrum of phenotypic and activation states. We now have limited knowledge of the tumor microenvironment (TME) determinants that influence the localization and the functions of the diverse myeloid cell populations in GBM. In this dataset, we have used imaging mass cytometry to identify and map the various myeloid populations in the human GBM tumor microenvironment (TME) using known markers for myeloid and neoplastic cells in GBM. Our analyses of these data found that different myeloid populations had distinct and reproducible compartmentalization patterns in the GBM TME that were driven by tissue hypoxia and varied homotypic and heterotypic cellular interactions. This dataset consists of imaging mass cytometry data (16-bit TIFF images) for 8 glioblastomas and 1 tonsil sourced from the Salford Royal NHS Trust Biobank.</p>
Impact of IDH Mutation and Adjuvant Chemo(radio)therapy on Survival Outcome in Grade II/III Astrocytoma
ClinicalTrials.gov study NCT06620926. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
CCRT With Temozolomide Versus RT Alone in Patients With IDH Wild-type/TERT Promoter Mutation Grade II/III Gliomas
ClinicalTrials.gov study NCT02766270. IPD Sharing: UNDECIDED. Countries: 1. Publications: 11.
Olaparib in Recurrent IDH-mutant Glioma
ClinicalTrials.gov study NCT03561870. IPD Sharing: NO. Countries: 1. Publications: 1.
Physiological MRI for Precision Radiotherapy IDH-wildtype Glioblastoma
ClinicalTrials.gov study NCT05970757. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
PRO-GLIO: PROton Versus Photon Therapy in IDH-mutated Diffuse Grade II and III GLIOmas
ClinicalTrials.gov study NCT05190172. IPD Sharing: YES. Countries: 1. Publications: 1.
Feasibility of ONCOhabitats for Surgical and Treatment Planning in IDH-Wildtype Glioblastoma (SINUE)
ClinicalTrials.gov study NCT07111195. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Amino Acid PET to Assess the Efficacy of IDH Inhibitor Treatments for IDH Mutated Gliomas
ClinicalTrials.gov study NCT07017790. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Prospective Cohort to Study the Effect of Temozolomide on IDH Mutational Low Grade Gliomas
ClinicalTrials.gov study NCT02209428. IPD Sharing: Not stated. Countries: 1. Publications: 15.
How the Precise Habitats Can Predict the IDH Mutation Status and Prognosis of the Patients With High-grade Gliomas
ClinicalTrials.gov study NCT04908267. IPD Sharing: NO. Countries: 1. Publications: 1.
Imaging mass cytometry data from IDH wildtype glioblastomas
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Early noninvasive metabolic biomarkers of mutant IDH inhibition in glioma
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MGMT promoter methylation and IDH mutation detected in 301 patients with GBM
<p>The datasets had listed the information of IDH mutation or wildtype at c.395G>A and MGMT promoter methylation status in 301 samples with GBM.</p>
Avelumab With Hypofractionated Radiation Therapy in Adults With Isocitrate Dehydrogenase (IDH) Mutant Glioblastoma
ClinicalTrials.gov study NCT02968940. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.