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93 results for “IL-13;”
Effects of ACTH4-10Pro8-Gly9-Pro10 on anti-inflammatory cytokine (IL-4, IL-10, IL-13) expression in acute spinal cord injury model (Sprague Dawley rats)
<p class="MsoNormal"><span><strong>Background:</strong> Spinal cord injury (SCI) is a destructive neurological and pathological state that causes major motor, sensory and autonomic dysfunctions. It's final neurological outcome determined from both primary and secondary injury process. Neuroinflammation is a key component of the secondary injury mechanisms with local and systemic consequences. </span>A neuroprotective compound, ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10 </sup>also known as Semax has <span>shown neuroprotective and anti-inflammatory properties. </span>ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> <span>also has actively used in the treatment of brain ischemia without serious complication reported. Here we analyzed the effects of </span>ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> in regulating inflammatory cascade in SCI by looking at the expression of anti-inflammatory cytokine IL-4, IL-10, IL-13 in acute compression SCI.</p> <p><span><strong>Method: </strong>We do laminectomy in Sprague Dawley rats at the second thoracic vertebrae. After laminectomy we expose the myelum and create mild SCI model with 20gr and severe SCI with 35gr aneurysm clips. </span>ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10 </sup><span>was administered intranasally to the treatment group and 0,9% NaCl to the control group (placebo). Both group was remain alive and terminated at 3 and 6 hour. </span>The preparations tissue sample were fixed in formalin and examined for immunohistochemistry<span>. Quantitative measurement of anti-inflammatory cytokine (</span>IL-4, IL-10, IL-13) was done in posterior horn with associated anti-monoclonal antibodies.</p> <p> </p> <p><strong>Result:</strong> Rats with mild SCI that were given ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> shown greater expression of IL-4, IL-10 and IL-13 at three hour post compression but only IL-10 and IL-13 elevated significantly at six hour. Rats with severe compression in ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> group shown greater expression of IL-10, IL-13 at three hour and IL-4, IL-10 at six hour compared with the placebo group.</p> <p> </p> <p><strong>Conclusion: </strong>Administration of ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> intranasal can increase anti inflammatory cytokine expression at Sprague Dawley rat model with mild and severe SCI. Expression of anti inflammatory cytokine was greater in mild compression and early hour (3 hour). Further research needs to be done to determine optimal dose and the actual clinical outcome in vivo.</p>
Effects of ACTH4-10Pro8-Gly9-Pro10 on anti-inflammatory cytokine (IL-4, IL-10, IL-13) expression in acute spinal cord injury model (Sprague Dawley rats)
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Data from: IL-13 and IL-17A activate β1 integrin through an NF-kB/Rho kinase/PIP5K1γ pathway to enhance force transmission in airway smooth muscle
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Chemerin, Fetuin-A, IL-34 and IL-13 Levels in Diabetic Periodontitis Patients
ClinicalTrials.gov study NCT06135532. IPD Sharing: NO. Countries: 1. Publications: 1.
Supplementary material 1 from: Tonyan ZN, Puppo IL, Saifitdinova AF, Vavilova TV, Glotov AS (2024) Assessment of quadrivalent characteristics influencing chromosome segregation by analyzing human preimplantation embryos from reciprocal translocation carriers. Comparative Cytogenetics 18: 1-13. https://doi.org/10.3897/compcytogen.18.115070
Supplementary information
Gene Expression Effects of IL-13 on Primary Human Airway Epithelial Cells
GEO Series GSE37693. Homo sapiens. 8 samples. Type: Expression profiling by array.
Innate type 2 immunity controls hair follicle commensalism by Demodex mites [IL-4, IL-13]
GEO Series GSE198657. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Human airway epithelial cells co-treated with IL-4 and IL-13 for seven days.
GEO Series GSE268072. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
IL-13 stimulation of primary human bronchial epithelial cells in control individuals and patients with asthma.
GEO Series GSE206510. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
Neutrophil activation by IL-4, IL-13 and IFN-g
GEO Series GSE218535. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Next Generation Sequencing Facilitates Quantitative Analysis of Normal human keratinocytes and IL-13 receptor alpha 1 and 2 knockdown human keratinocytes Transcriptomes
GEO Series GSE172006. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
IL-13 Overexpression in IL4Ra^Flox Alb^Cre mice
GEO Series GSE70705. Mus musculus. 14 samples. Type: Expression profiling by array.
Global transcriptome analysis of IL-33, IL-25, IL-13, TSLP, IL-4, and IL-9 overexpression in mouse spleen
GEO Series GSE313261. Mus musculus. 49 samples. Type: Expression profiling by high throughput sequencing.
Regulation of gene expression in enteroids by butyrate and IL-13
GEO Series GSE223822. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Liver ILC2s suppress gluconeogenesis and limit blood glucose elevation through IL-13 signaling [scRNA-seq_ILC2]
GEO Series GSE189285. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Recombinant RSV G protein vaccine induces enhanced respiratory disease via IL-13 and mucin overproduction
GEO Series GSE272499. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Effects of anti-IL13RA mAbs on IL-4 or IL-13 signalling
GEO Series GSE47527. Homo sapiens. 35 samples. Type: Expression profiling by array.
RNA-sequencing of lineage-traced memory Th2 cells after Heligmosomoidese polygyrus bakeri infection: IL-5 vs. IL-13
GEO Series GSE314225. Mus musculus. 23 samples. Type: Expression profiling by high throughput sequencing.
Expression profiling of IL-13 stimulated PBMCs with and without an IL-13R antagonist
GEO Series GSE79027. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
IL-13 neutralization effect on COVID-19 severity
GEO Series GSE180557. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.