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137
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137 results for “ILC2”
Diet-mediated constitutive induction of novel IL4+ ILC2 cells maintains intestinal homeostasis in mice
<p>Group 2 innate lymphoid cells (ILC2s) expressing IL-5 and IL-13 are localized at various mucosal tissues and play critical roles in the induction of type 2 inflammation, response to helminth infection, and tissue repair. Here we reveal a unique ILC2 subset in the mouse intestine that constitutively expresses IL-4 together with GATA3, ST2, KLRG1, IL-17RB, and IL-5. In this subset, IL-4 expression is regulated by mechanisms similar to but distinct from those observed in T cells and is partly affected by IL-25 signaling. Although the absence of the microbiota had marginal effects, feeding mice with a vitamin B1-deficient diet compromised the number of intestinal IL-4+ ILC2s. The decrease in the number of IL-4+ ILC2s caused by the vitamin B1 deficiency was accompanied by a reduction in IL-25-producing tuft cells. Our findings reveal that dietary vitamin B1 plays a critical role in maintaining interaction between tuft cells and IL-4+ ILC2s, a previously uncharacterized immune cell population that may contribute to maintaining intestinal homeostasis.</p>
Diet-mediated constitutive induction of novel IL4+ ILC2 cells maintains intestinal homeostasis in mice
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Examination of RORa and GATA-3 binding sites in ILC2 by ChIP-seq
GEO Series GSE146743. Mus musculus. 10 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
CRISPR-Cas screen in ILC2 identifies Mef2d as a regulator of GATA3 and type-2 immunity [ChIP-Seq]
GEO Series GSE242030. Mus musculus. 17 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Neuropeptide CGRP limits ILC2 responses and constrains type 2 inflammation
GEO Series GSE131996. Mus musculus. 54 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Piezo1-mediated Mechanotransduction Shapes ILC2 Translational Activity, Functions, and Lung Pathogenicity
GEO Series GSE278085. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Exploration of specific gene expression behind the intercellular heterogeneity of type 2 cytokine secretion activity of Group 2 innate lymphoid cell (ILC2) isolated from peripheral blood of severe ast
GEO Series GSE213810. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Comparison of transcriptomic profiles of macrophages cultures without ILC2, in presence of ILC2 from uninfected mice, and in presence of ILC2 from MuHV-4 infected mice.
GEO Series GSE218245. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Analysis of wild type and Sema6d-/- lung ILC2 transcriptomes in IL-33 induced acute lung inflammation
GEO Series GSE198659. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Down-regulation of E protein activity augments an ILC2 differentiation program in the thymus
GEO Series GSE94597. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Single-Cell Transcriptomic Atlas of Human Hepatic ILCs Reveals the Enrichment of ILC2 in Liver Cancer
GEO Series GSE162616. Homo sapiens. 13 samples. Type: Expression profiling by high throughput sequencing.
Sexual dimorphism in skin immunity is mediated by androgen-ILC2-dendritic cell axis [Bulk RNA-seq]
GEO Series GSE253293. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Dissection of in vivo fasting on pancreatic ILC2 function [RNA-Seq]
GEO Series GSE273959. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Liver ILC2s suppress gluconeogenesis and limit blood glucose elevation through IL-13 signaling [scRNA-seq_ILC2]
GEO Series GSE189285. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Dietary fiber is a critical determinant of pathologic ILC2 responses and intestinal inflammation
GEO Series GSE255243. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
LKB1 regulates adipose tissue ILC2 function through regulating mitochonrial
GEO Series GSE225097. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Regulatory network analysis of Dclk1 gene expression reveals a tuft cell-ILC2 axis that inhibits pancreatic tumor progression [RNA-seq]
GEO Series GSE259357. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
RNA-seq analysis of the Innate Lymphoid Cells type 2 (ILC2) or their precursors (ILC2p ) sorted from WT and Tgfbr2-/- mice
GEO Series GSE140168. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
CRISPR-Cas screen in ILC2 identifies Mef2d as a regulator of GATA3 and type-2 immunity [CRISPR screen]
GEO Series GSE262028. Mus musculus. 8 samples. Type: Other.
CRISPR-Cas screen in ILC2 identifies Mef2d as a regulator of GATA3 and type-2 immunity [ATAC-Seq]
GEO Series GSE242146. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.