Find research datasets worth reusing

VISION Invited lecture - Bariatric surgery and non-alcoholic fatty liver disease

Recording and presentation of the invited lecture that took place online on 16 June 2021 - Pantelis Antonakis, MD, PhD - Bariatric surgery and non-alcoholic fatty liver disease. Bariatric surgery is a documented solution for morbid obesity. Additionally to excess weight loss, significant improvement in comorbidities is an established benefit after bariatric operations. In recent years, non-alcoholic fatty liver disease (NAFLD) has emerged as one of these comorbidities. Herein we will review the data supporting the positive effect of bariatric surgery in patients with NAFLD.

VISION Invited lecture - Microfluidic technologies and their applications in cell biology

Recording and presentation of the invited lecture that took place online on 27 April 2021 - Thorsten Knoll - Microfluidic technologies and their applications in cell biology. In the past twenty years, microfluidic devices and systems have gained in importance in the field of bioanalytics and biomedicine, not only in research but also in the market. Lab-on-chip systems with microfluidic structures serve for medical tests with body fluids or extractions from fluids. Besides, microfluidic systems are also used for cell handling and culturing, for the mixing of liquids and for measuring quantitative amounts of components in liquid samples. Fraunhofer IBMT develops microfluidic systems for various applications in the field of life sciences. Different miniaturized approaches and solutions exist e.g. for transport studies or toxicological assays with single cells, 2D cell layers or 3D cell aggregates. The online lecture will cover some basic considerations regarding microfluidics and IBMT’s technological solutions for the fabrication of microfluidic devices and their use in different application scenarios. Furthermore, the presentation describes solutions for the integration of the microfluidic devices in a complete set-up comprising of peripheral fluidic components and optical or electrical measurement systems.

VISION Invited lecture - Molecular and Cellular mechanisms/biomarkers in PDAC

Recording and presentation of the invited lecture that took place online on 11 November 2020 - Dr Laura Garcia Bermejo - Molecular and Cellular mechanisms/biomarkers in PDAC. Pancreatic ductal adenocarcinoma is a fatal disease that presents metastases at diagnosis in most of the cases leading to cancer-associated death. Mutations in drivers’ genes including KRas, CDKN2, Tp53 and SMAD4 and DNA repair genes have been already linked to pancreas cancer development. Pancreatic cancer cells possess properties of plasticity highlighting the epithelial mesenchymal transition and pluripotency genes as critical mediators in pancreas cancer development and progression. Both, EMT and plasticity could be responsible of the limited efficacy of current treatments. Additionally, microRNAs (miRNAs) small non-coding RNAs that regulate the expression of multiple messengers in the post-translation process emerge as promising biomarkers for prognosis, patient stratification and response to advanced pancreatic therapies. Profiling of deregulated miRNAs in pancreatic cancer can contribute to accurate diagnosis and molecular subtype characterization as well as indicate optimal treatment and predict response to therapy. Furthermore, understanding the main effector genes upon miRNAs regulation can also identify miRNAs as potential therapeutic candidates. However, obstacles to the translation of miRNAs into the clinical practice should be also considered, therefore validation of the profiles and the specific role of miRNAs in pancreas cancer development and progression are required for real clinical application.

VISION Invited lecture - Future approaches of pancreatic ductal adenocarcinoma

Recording and presentation of the invited lecture that took place online on 14 October 2020 - Prof Alfredo Carrato - Future approaches of pancreatic ductal adenocarcinoma. Although pancreatic ductal adenocarcinoma (PDAC) is not so frequent, it is the third leading cause of cancer death. As it shows non-specific symptoms it is diagnosed late and only 20% of patients are surgery candidates. Tumor recurrs locally or distantly after surgery in two thirds of them. Only 5% of PDAC patients survive 10 years. Targeted therapies have not yet proven their efficacy and treatment prescribed consists of chemotherapy combinations. PDAC has a dense stroma that reaches an 80% of the tumor, helping PDAC epithelial tumor cells to evade the immune system and growth, invade and metastasize through a crosstalk among PDAC cells and fibroblasts, macrophages, pericytes, stroma, etc. Targeting the stromal constituents may result in a step forward a better treatment efficacy. PDAC microbiome is unique and has been identified into the cancer cells and the local immune cells. Wisely management of the different resident microbial species could also result in prevention and another alternative for treatment. The identification of the PDAC high-risk population and the development of a convenient screening program is an objective to be reached for an earlier diagnosis and a potential advantage as more patients will be candidates for surgery, but to know in depth and detail the biology of the tumor and its interaction with the host will lead to a better treatment design and a real benefit of our patients.

VISION Invited lecture - Advances in familial pancreatic cancer

Recording and presentation of the invited lecture that took place online on 28 October 2020 - Dr Julie Earl - Advances in familial pancreatic cancer. The prognosis of patients diagnosed with pancreatic cancer (PC) is dismal with a 5 year survival rate of around 5% as the majority of patients present with advanced disease. Very few risk factors have been identified, although there is good evidence to suggest that smoking, obesity, a family history of pancreatic cancer, pancreatitis and diabetes increase pancreatic cancer risk. Sporadic PC occurs worldwide at an approximate frequency of 1 in 10,000 people. However, the risk of developing PC increases according to the number of affected family members, the standard incidence ratio is 4.6 with one affected family member to 32 with three affected family members. Familial pancreatic cancer (FPC) is defined as a family with at least one pair of affected first degree relatives and an estimated 4-10% of pancreatic cancers diagnosed have a familial background. Approximately 10–13% of FPC families carry germline mutations in BRCA2, PALB2, ATM, CHEK2, CDKN2A, Lynch syndrome mismatch repair genes, Fanconi anaemia related genes and PRSS1 and SPINK2 (hereditary pancreatitis), among others. The understanding of genetic basis of hereditary pancreatic cancer has important implications for the identification of true high-risk individuals in order to optimise secondary screening strategies.

VISION Invited lecture - New Perspectives in Clinical Trials

Recording and presentation of the invited lecture that took place online on 15 June 2022 - Prof. Stefano Bonassi, Ph.D., ERT - New Perspectives in Clinical Trials. Clinical trials are our best approach to generate clinical evidence. Since the early stages in the first decades of the past century, clinical trial has been in continuous evolution. Innovation has interested the formulation of stopping guidelines for safety, efficacy, and futility; the use of internet, changes in the way the informed consent is requested, the introduction of pragmatic trials, the challenge of personalized medicine, the concept of non-inferiority, and many others. Today, trials range from a single person to hundred-thousand people, from a single lab to hundreds of centers around the world, from simple two-arm randomizations to increasingly complex study designs. The lecture will address issues related to the performance of clinical trials, how to deal with the increasing use of the internet, the dramatic change concerning ethics in clinical studies.

VISION Invited lecture - Radiomics and radiogenomics in cancer

Recording and presentation of the invited lecture that took place online on 8 February 2023 - Carolina de la Pinta, MD. - Radiomics and radiogenomics in cancer. Radiomics and radiogenomics are very young research fields. These tools have great potential for clinical use in the context of personalized medicine. Their utility has been demonstrated in early diagnosis, differential diagnosis, treatment selection and patient prognosis. Undoubtedly show tremendous potential for improving our knowledge and developing new clinical tools, based on the application of computer techniques and data processing.

VISION Invited lecture - Objective: Personalised Prevention of Pancreatic Cancer

Recording of the invited lecture that took place online on 16 December 2021 - Núria Malats, MD, MPH, PhD - Objective: Personalised Prevention of Pancreatic Cancer. Identifying the population at high risk of developing non-hereditary pancreatic cancer in order to offer them to enter screening programs and diagnose cancer in early stages, is a must. To this end, we integrate information on the risk factors for this tumor with biomarkers determined at the omics level, including genomics and microbiome. All this information comes from a large study carried out in 28 centres from six European countries. For the integration of this big molecular data with epidemiological and clinical data, we use artificial intelligence tools. In the lecture, I will go through the most recent achievements of these collective efforts.

VISION Invited lecture - Genomic instability, microenvironment and telomere homeostasis in colorectal cancer

Recording and presentation of the invited lecture that took place online on 4 November 2021 - Pavel Vodička, MD, Ph.D. - Genomic instability, microenvironment and telomere homeostasis in colorectal cancer. Pavel Vodicka1,2,3, Sona Vodenkova1, Michal Kroupa1,3, Alena Opattova1,2,3, Kristyna Tomasova1,3, Ludmila Vodickova1,2,3 1 Institute of Experimental Medicine, Czech Acad. Sci., Videnska 1083, Prague 4, Czech Rep. 2 Inst. Biology and Med. Genet., 1st Faculty of Medicine, Charles University, Albertov 6, Prague 2, Czech Rep. 3 Biomedical Center, Faculty of Medicine in Pilsen, Charles University Prague, Pilsen, 30100, Czech Rep. Colorectal cancer (CRC) continues to be one of the leading malignancies and causes of tumour-related deaths worldwide. Both impaired DNA repair mechanisms and disrupted telomere length homeostasis represent potential culprits in CRC onset, its dissemination in the body and prognosis. Above parameters are becoming critical as prognostic markers, since CRC therapy is based on compounds interacting with DNA. DNA repair capacity in CRC patients have recently been studied in order to address prediction of therapy response. Due to the substantial interindividual variations in DNA repair capacities and relative telomere length, these markers may pose a possible contribution in individualized therapeutical regimen of CRC patients. Telomere attrition, responsible for replicative senescence in healthy cells, may become a hallmark of malignant transformation of the cell due to by-passing cell cycle checkpoints. Telomerase – a key enzyme keeping homeostasis of telomere - is almost ubiquitous in advanced solid cancers, including CRC, and its expression is fundamental to cell immortalization. Here we present our data based on the investigation of base excision repair capacities and relative telomere length in tumor tissues and adjacent non-malignant mucosa of sporadic CRC patients. The relative gene expression of telomerases is monitored as well. Particular attention will be dedicated to the CRC phenotypes and clinicopathological characteristics. We also addressed telomere homeostasis in peripheral blood lymphocytes of CRC patients in several consecutive samplings (at diagnosis, immediately after treatment and in additional follow-up intervals), which could provide us the insight into the treatment response. This aspect is of particular relevance, since there is currently a persistent effort to develop therapeutics, which are telomerase-specific and gentle to non-malignant tissue. However, in practice, we are at the dawn of clinical trials. Additionally, emerging crosstalks between DNA repair and telomere length homeostasis may cast some lights on a dynamic of genomic instability, a fundamental hallmark (or cause) of cancer. Acknowledgement: GACR 21-04607X, 19-10543S, AZV NV18/03/00199

opencc-by-nc-4.0Sep 2018View details →

zenodo36/100

Ideas and feedback collected during the INVITE Co-creation Workshop

In the framework of the INVITE Co-Creation Workshop, a diverse group of OI stakeholders engaged in a series of co-creative brainstorming and ideation sessions to co-define demand-driven designs and features for INVITE’s pilots and OI2 Lab. During the workshop six tables were set up to discuss six themes, each of which addressed key aspects of the pilots, services and tools to be deployed through the OI2 Lab. The discussions followed a semi-structured approach and were guided by six key questions, unique to each theme. With that in mind, this dataset comprises of both qualitative and quantitative data, as derived from the participants’ responses to each of these six questions per theme along with any additional ideas.

zenodo36/100

INVITE: User needs and requirements

This data was collected during the qualitative interview-based survey that was conducted in the framework of INVITE, which aimed at revealing the needs and requirements of prospective users and stakeholders of the OI2 Lab. In particular, a stratified purposeful sampling methodology was employed in order to include diverse OI stakeholders of the quadruple helix (i.e. from businesses and investors in the private sector over to academia and public authorities as well as civil society) and across different regions in Europe. Data in the form of interview transcripts was collected by means of semi-structured interviews and encompass information on the different ways in which OI actors are currently engaged (or not) in OI, various enablers / barriers that appear to be fostering / hindering their participation in OI as well as insights into the perceived knowledge, skills and support that they may need in order to successfully adopt and apply OI.

opencc-by-nc-4.0Aug 2018View details →

ClinicalTrials.gov36/100

St. Joe's Invitation Effectiveness Study

ClinicalTrials.gov study NCT04658888. IPD Sharing: NO. Countries: 1. Publications: 2.

closedIPD-NOFeb 2026View details →

opencc-by-4.0Aug 2024View details →

TEFNET24: Reference Packet Optical Network Topology for Edge to Core Transport [Invited]

In this paper, we introduce TEFNET24, a reference multi-layer hierarchical network topology that spans from access to core networks, specifically designed to meet the demands of beyond-5G and and prepared for next-generation 6G communication systems. This topology, inspired by the actual network deployments of Telefónica in medium-sized countries in Europe and America, integrates both IP and optical (DWDM) layers to provide a comprehensive framework for network design, optimization, and analysis. Our primary contribution is the development of an open-source benchmarking network, accessible to both researchers and industry professionals. This resource aims to facilitate the study and advancement of integrated IP and optical networks, allowing researchers to address key challenges such as traffic aggregation, latency reduction, cost efficiency, and support for advanced applications. We provide guidelines for utilizing this benchmark network, enabling users to evaluate and enhance their solutions for AI-driven network management, ultra-reliable low-latency communication, enhanced mobile broadband, and massive machine-type communication. By sharing this detailed and practical benchmarking network, we seek to foster innovation and collaboration within the optical network community, driving forward the capabilities and performance of future communication networks.

opencc-by-4.0Nov 2021View details →

Invitation letters design

Invitation letters design. Four interventions used in the SWAT.

opencc-by-4.0May 2022View details →

Source data and codes for the paper "Inviting atomic mechanics to macro-continua: A study on monocrystalline Si using a spatial multilevel coarsening model"

Source data and codes for the paper "Inviting atomic mechanics to macro-continua: A study on monocrystalline Si using a spatial multilevel coarsening model" This file includes  - Source data for Figs 1-5 and Supplementary Materials - LAMMPS codes and raw log files used to produce the results of this study