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Dataset results
40 results for “IRE1”
Dataset for identification of peptidomimetics and FDA approved drugs binding to novel allosteric pocket of the IRE1 RNase domain.
<p>Input files, protein-peptide and ligand docking datasets, and simulation trajectories, compressed in "rar" format. All calculations performed using the Schrödinger 2020-2 / 2020-3 software (modules Glide, Phase, Desmond). </p> <p>SI includes folders:</p> <p>1- "Peptide" folder contains the best peptide "Docking" complexes and "Pharmacophore" models </p> <p>2-"Quercitrin" folder contains the molecular "Docking", "MMGBSA" calculations, and "MD" simulation</p> <p>3-"Pemetrexed" folder contains the molecular "Docking", "MMGBSA" calculations, and "MD" simulation</p> <p> </p>
Dataset for molecular simulations of human IRE1 tetramer models.
<p>Dataset from SymmDock protein-protein docking of different conformers of IRE1 tetramers (dimer of back-to-back dimers); input files scripts and trajectories from subsequent MD simulations using Gromacs. Videos showing PC1 and PC2 of tetramers <em>y</em>IRE1<sub>4</sub> (S1, S2), <em>h</em>IRE1<sub>4</sub>(R) (S3, S4), <em>h</em>IRE1<sub>4</sub>(L) (S5,S6) and <em>h</em>IRE1<sub>4</sub>(S) (S7,S8), in avi format.</p>
Dataset for "Unconventional Cleavage mechanism of XBP1 mRNA by IRE1 RNase"
<p>IRE1_XBP1_Docked.zip contains the pdb files of the docked xbp1 toward monomers A and B in the IRE1 dimer.<br> MD.tar.gz contains the 7 restrained MD simulations followed by 50 ns unrestrained MD run. The extension for the final unrestrained MD (50 ns to 200 ns) has been uploaded as MD_extension.tar.gz<br> QMMMM_MD.tar.gz contains the trajectory files of the QMMM WT_MetaD simulation.<br> QMMMMD_High.mp4 is a high quality video file showing the XBP1 cleavage by IRE1 during QMMM_MD simulation.</p>
Dataset for study of inhibition or activation of yeast and human IRE1 dimers, by Quercetin and Quercitrine.
<p>Docked structures, MD trajectories, BPMD simulation files and video of RNase motion cycles in apo scIre1p dimer. </p>
Peptidomimetics-based identification of FDA approved compounds inhibiting IRE1 activity: Simulation Data
<p>Protocols and data sets for docking and MD simulations of Methotrexate, Cefoperazone, Folinic acd and Folic acid interaction with IRE1. All docking data based on Glide (Schrödinger), and all MD simulations are based on the Gromacs software. 2D interaction maps from the initial docking of the four molecules to the four Lysine sites, and from snapshots every 100 ns of the 500 ns MD simulations of the molecules interacting with Lys599 (kinase site) and Lys907 (RNase site). 2D interaction maps produced using Schrödinger. </p>
Interferon regulatory factor 4 mediates non-enzymatic IRE1 dependency in multiple myeloma cells [RNA-Seq]
GEO Series GSE288674. Homo sapiens. 45 samples. Type: Expression profiling by high throughput sequencing.
Natural killer cell proliferation requires canonical IRE1 function during viral infection (RNA-Seq)
GEO Series GSE236819. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
The UPR Transducer IRE1 Promotes Breast Cancer Malignancy by Degrading Tumor Suppressor microRNAs
GEO Series GSE156332. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Optogenetic Clustering of Human IRE1 Reveals Differential Regulation of Transcription and mRNA Splice Isoform Abundance by the UPR
GEO Series GSE302406. Homo sapiens. 39 samples. Type: Expression profiling by high throughput sequencing.
RNA sequencing identifies novel regulated IRE1-dependent decay targets that affect multiple myeloma survival and proliferation
GEO Series GSE152070. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
A role for the ribosome-associated complex in activation of the IRE1 branch of UPR
GEO Series GSE173852. Homo sapiens. 16 samples. Type: Other.
Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress
GEO Series GSE131146. Saccharomyces cerevisiae. 24 samples. Type: Expression profiling by array.
LOXL2 drives epithelial-mesenchymal transition via activation of IRE1-XBP1 branch of unfolded protein response.
GEO Series GSE90605. Homo sapiens; Canis lupus familiaris. 8 samples. Type: Expression profiling by array.
Novel XBP1s-independent function of IRE1 RNase in HIF-1a-mediated glycolysis upregulation in human macrophages
GEO Series GSE233446. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
E2F Deregulation Compromises ER homeostasis by Attenuating IRE1 Activity
GEO Series GSE294319. Drosophila melanogaster. 6 samples. Type: Expression profiling by high throughput sequencing.
Natural killer cell proliferation requires canonical IRE1 function during viral infection (CITE-Seq)
GEO Series GSE236820. Mus musculus. 18 samples. Type: Other.
The IRE1 Pathway Regulates Honey Bee Unfolded Protein Response Gene Expression
GEO Series GSE139368. Apis mellifera. 6 samples. Type: Expression profiling by high throughput sequencing.
The IRE1-XBP1 pathway promotes natural killer cell responses against viral infection and cancer by regulation of c-Myc
GEO Series GSE113214. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
IRE1 and XBP-1 effects on the Drosophila unfolded protein response
GEO Series GSE4867. Drosophila melanogaster. 18 samples. Type: Expression profiling by array.
Transcriptome analysis of ire1 mutants after treatment with or without tunicamycin in the presence of actinomycin D
GEO Series GSE39690. Arabidopsis thaliana. 12 samples. Type: Expression profiling by array.
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Allen Brain Atlas
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.