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ShareScore release 0.9.0
Dataset results
9 results for “Immune repertoire profiling”
Development of ferret immune repertoire reference resources and single-cell-based high- throughput profiling assays
<p>We performed long read transcriptome sequencing of ferret splenocyte and lymph node samples full-length, non-chimeric circular consensus sequencing (CCS) reads to obtain over 120,000 high-quality immunoglobin (Ig) and T cell receptor (TCR) transcripts.</p>
Immune repertoire profiling reveals that clonally expanded B and T cells infiltrating diseased human kidneys can also be tracked in the blood
<p>Recent advances in high-throughput sequencing allow for the competitive analysis of the human B and T cell immune repertoire. In this study we compared Immunoglobulin and T cell receptor repertoires of lymphocytes found in kidney and blood samples of 10 patients with various renal diseases based on next-generation sequencing data.</p>
Immune repertoire profiling reveals its clinical application potential and triggers for Neuromyelitis Optica Spectrum Disorders
<p>This dataset, containing TCRbeta-chain sequcening data of Neuromyelitis Optica Spectrum Disorders patients and healthy, is the basis for the following publication: "Immune repertoire profiling reveals its clinical application potential and triggers for Neuromyelitis Optica Spectrum Disorders".</p>
Benchmark datasets for "Detecting T-cell expansion and quantifying clone survival from deep profiling of immune repertoires"
<p>T-cell receptor repertoire sequencing datasets describing time courses obtained for vaccination, normal aging and blood transplant cases. Datasets reported here were previously published (except for Tem/Tcm data), this is just a compendium of selected samples that is properly pre-processed and formatted.</p>
Single cell and immune repertoire profiling of COVID-19 patients reveal novel therapeutic candidates
<p>COVID-19, a novel pneumonia caused by SARS-CoV-2, has rapidly become the largest threat to public health. Recent studies reported lymphocytopenia but also expansions of antigen-specific T/B cells during early-recovery stage. Here we investigated 16 early-recovery patients using scRNA-seq, HLA-genotyping and deep immune repertoire profling. Our analysis revealed 916 COVID-19-specific TCR groups enriched for a novel cytotoxic CD8+ phenotype with both resident memory (ZNF683+) and tissue exit (SIRP5) markers, and identified 114 statistically-confident virus epitopes. Further, we uncovered 374 BCR groups with somatic hypermutations and/or class switch recombinations. Molecular dynamics simulations revealed 15% of the highly expanded groups may serve as neutralizing antibodies against the virus Spike protein. Finally, we discovered that bacterial infection in COVID-19 patients may elevate monocytic myeloidderived suppressor cells via TLR4/NF!B signaling and cause disease aggravation. Together, we expect our findings and immune-receptor datasets to provide immediate therapeutic options against the pandemic of COVID-19.</p>
CITE-sequencing profiling establishes immune cell repertoire in peripheral blood and pancreas of new-onset diabetic NOD mice
GEO Series GSE214031. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Global expression profiling of peripheral Qa-1 class Ib-restricted CD8aa+TCRab+ regulatory T Cells reveals innate-like features: implications for immune regulatory repertoire
GEO Series GSE22985. Mus musculus. 6 samples. Type: Expression profiling by array.
Molecule template estimation using Validator Barcodes as an alternative to UMIs in multiplex PCR for adaptive immune repertoire profiling
GEO Series GSE297422. Mus musculus; Homo sapiens. 18 samples. Type: Other.
Longer read lengths are required for RNA velocity analysis of single-cell RNA-sequencing with paired immune repertoire and transcriptome profiling
GEO Series GSE169657. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.