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54 results for “Immunopathology”
Dataset - The cGAS-STING pathway drives type I IFN immunopathology in COVID-19
<p>Dataset corresponding to the LoC studies in the manuscript titled The cGAS-STING pathway drives type I IFN immunopathology in COVID-19. The following data are included:</p> <p>BioEM.zip: Volumetric electron microscopy - representative movies of volumetric scans of fields of view of the vascular face of uninfected control and SARS-CoV-2 infected LoCs. Blender file containing reconstruction of mitochondria.</p> <p>Cleaved-caspase3.zip: Imaris files for analysis of 3D stacks from two- and three-component LoCs immunostained for cleaved-caspase 3.</p> <p>IFN beta.zip: Imaris files for analysis of 3D stacks from two- and three-component LoCs immunostained for IFN beta.</p> <p>PhosphoSTING.zip: Imaris files for analysis of 3D stacks from two component LoCs immunostained for phosphoSTING.</p> <p>Proteomics_R_code.Rmd: Annotated custom scripts in R for the analysis of the proteomics data.</p>
The immunopathological landscape of human pre-TCRα deficiency: from rare to common variants
<div> <p>We describe humans with rare biallelic loss-of-function PTCRA variants impairing pre–a T cell receptor (pre-TCRa) expression. Low circulating naive ab T cell counts at birth persisted over time, with normal memory ab and high gd T cell counts. Their TCRa repertoire was biased, which suggests that noncanonical thymic differentiation pathways can rescue ab T cell development. Only a minority of these individuals were sick, with infection, lymphoproliferation, and/or autoimmunity. We also report that 1 in 4000 individuals from the Middle East and South Asia are homozygous for a common hypomorphic PTCRA variant. They had normal circulating naive ab T cell counts but high gd T cell counts. Although residual pre-TCRa expression drove the differentiation of more ab T cells, autoimmune conditions were more frequent in these patients compared with the general population.</p> </div>
Contribution of parasite and host genotype to immunopathology of schistosome infections
<p>The present dataset contains all the phenotype data (.csv files) and R scripts used for data analysis and generation of figures (Fig. 2-6) present in the manuscript entitled "Contribution of parasite and host genotype to immunopathology of schistosome infections."</p>
Data from: Clinical correlation of multiple sclerosis immunopathological subtypes
<p><b>Objective:</b> To compare clinical characteristics across immunopathological subtypes of patients with multiple sclerosis.</p> <p><b>Methods:</b> Immunopathological subtyping was performed on specimens from 547 patients with biopsy and/or autopsy confirmed CNS demyelination.</p> <p><b>Results: </b>The frequency of immunopathological subtypes were pattern I (23%), II (56%), and III (22%). Immunopatterns were similar in terms of age at autopsy/biopsy (median age 41 years, range 4-83 years, p=0.16) and proportion female (54%, p=0.71). Median follow-up after symptom onset was 2.3 years (range 0-38y). In addition to being overrepresented among autopsy cases (45% vs. 19% in biopsy cohort, p<0.001), index attack-related disability was higher in pattern III vs. pattern II (median EDSS 4 vs. 3, p=0.02). Monophasic clinical course was more common in patients with pattern III than pattern I or II (59% vs. 33% vs. 32%, p<0.001). Similarly, patients with pattern III pathology were likely to have progressive disease compared to patients with patterns I or II, when followed for ≥5 years (24% overall, p=0.49), with no differences in long-term survival, despite a more fulminant attack presentation.</p> <p><b>Conclusion:</b> All three immunopatterns can be detected in active lesions, although they are found less frequently later into the disease due to the lower number of active lesions. Pattern III is associated with a more fulminant initial attack than either pattern I or II. Biopsied patients appear to have similar long-term outcomes irrespective of their immunopatterns. Progressive disease is less associated with the initial immunopattern and suggests convergence into a final common pathway related to the chronically denuded axon.</p>
Immunopathology of Autoimmune Hemolytic Anemia
ClinicalTrials.gov study NCT02158195. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Immunopathological Analysis in a French National Cohort of Membranous Nephropathy
ClinicalTrials.gov study NCT04326218. IPD Sharing: NO. Countries: 0. Publications: 1.
Data from: Clinical correlation of multiple sclerosis immunopathological subtypes
Open the record for dataset details and reuse information.
The immunopathological landscape of human pre-TCRα deficiency: from rare to common variants
Open the record for dataset details and reuse information.
GATA4 regionalizes intestinal metabolism and commensal bacterial colonization to prevent immunopathology
GEO Series GSE205743. Mus musculus. 80 samples. Type: Expression profiling by high throughput sequencing.
Long-term survival of influenza virus infected club cells drives immunopathology
GEO Series GSE58926. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Inducible costimulator ligand (ICOSL) on CD19+ B cells is involved in immunopathological damage of rheumatoid arthritis (RA)
GEO Series GSE216491. Mus musculus. 2 samples. Type: Expression profiling by array.
The immunopathological landscape of human pre-TCRα deficiency: from rare to common variants
GEO Series GSE243927. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing; Other.
Immune-Responsive Gene 1 expression in myeloid cells prevents neutrophil mediated immunopathology during Mycobacterium tuberculosis infection, in vitro neutrophils data
GEO Series GSE98456. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Analyses of lung early responses to RSV in the neonatal environment reveal key roles for DC and type I IFN in controlling immunopathologic imprinting.
GEO Series GSE42759. Mus musculus. 16 samples. Type: Expression profiling by array.
Mitochondria–lysosome crosstalk dictates the progressive differentiation of Treg cells to limit inflammation-associated immunopathology [scRNA-seq1]
GEO Series GSE262494. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing; Other.
Immune-Responsive Gene 1 expression in myeloid cells prevents neutrophil mediated immunopathology during Mycobacterium tuberculosis infection, in vivo neutrophil data
GEO Series GSE98457. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
Theiler’s Virus-Mediated Immunopathology in the CNS and Heart: Roles of Organ-Specific Cytokine and Lymphatic Responses [RNA-Seq]
GEO Series GSE120041. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing.
ADAR1 mutation causes ZBP1-dependent immunopathology
GEO Series GSE200854. Mus musculus. 17 samples. Type: Expression profiling by high throughput sequencing.
Obesity Potentiates TH2 Immunopathology Via Dysregulation of PPARg
GEO Series GSE189216. Mus musculus. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Mitochondria-lysosome crosstalk dictates the progressive differentiation of Treg cells to limit inflammation-associated immunopathology [ATAC-seq2]
GEO Series GSE263802. Mus musculus. 7 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.