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97 results for “Immunophenotype”
Spatial immunophenotyping of the tumor microenvironment in non-small cell lung cancer
<p>A dataset with spatial immune cell information on a lung cancer cohort from Uppsala University Hospital, Sweden, with anonymized clinical data. For more information please refer to the 'readme' file and the original study (https://doi.org/10.1016/j.ejca.2023.02.012).</p>
Exploratory mass cytometry analysis reveals immunophenotypes of cancer treatment-related pneumonitis
<p>Anti-cancer treatments can result in various adverse effects, including infections due to immune suppression/dysregulation and drug-induced toxicity in the lung. One of the major opportunistic infections is <em>Pneumocystis jirovecii</em> pneumonia (PCP), which can cause severe respiratory complications and high mortality rates. Cytotoxic drugs and immune-checkpoint inhibitors (ICIs) can induce interstitial lung diseases (ILDs). Nonetheless, the differentiation of these diseases can be difficult, and the pathogenic mechanisms of such diseases are not yet fully understood. To better comprehend the immunophenotypes, we conducted an exploratory mass cytometry analysis of immune cell subsets in bronchoalveolar lavage fluid from patients with PCP, cytotoxic drug-induced ILD (DI-ILD), and ICI-associated ILD (ICI-ILD) using two panels containing 64 markers. In PCP, we observed an expansion of the CD16<sup>+</sup> T cell population, with the highest CD16<sup>+</sup> T proportion in a fatal case. In ICI-ILD, we found an increase in CD57<sup>+</sup> CD8<sup>+</sup> T cells expressing immune checkpoints (TIGIT<sup>+</sup> LAG3<sup>+</sup> TIM-3<sup>+</sup> PD-1<sup>+</sup>), FCRL5<sup>+</sup> B cells, and CCR2<sup>+</sup> CCR5<sup>+</sup> CD14<sup>+</sup> monocytes. These findings uncover the diverse immunophenotypes and possible pathomechanisms of cancer treatment-related pneumonitis.</p>
Mass cytometry immunophenotyping data of two-week-old mouse pups' spleens depleted of maternal cells
<div> <div> <div> <p>The maternal cells transferred into the fetus during gestation persist long after birth in the progeny. These maternal cells have been hypothesized to promote the maturation of the fetal immune system in utero but there are still significant gaps in our knowledge of their potential roles after birth. To provide insights into these maternal cells' postnatal functional roles, we set up a transgenic mouse model to specifically eliminate maternal cells in the neonates by diphtheria toxin injection and confirmed significant depletion in the spleens. We then performed immunophenotyping of the spleens of two-week-old pups by mass cytometry to pinpoint the immune profile differences driven by the depletion of maternal cells in early postnatal life. We observed a heightened expression of markers related to activation and maturation in some natural killer and T cell populations. We hypothesize these results to indicate a potential postnatal regulation of lymphocytic responses by maternal cells. Together, our findings highlight an immunological influence of maternal microchimeric cells postnatally, possibly protecting against adverse hypersensitivity reactions of the neonate at a crucial time of new encounters with self and environmental antigens.</p> </div> </div> </div>
Immunophenotyping of Fresh Stromal Vascular Fraction From Adipose Derived Stem Cells (ADSC) Enriched Fat Grafts
ClinicalTrials.gov study NCT01771913. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Exploratory mass cytometry analysis reveals immunophenotypes of cancer treatment-related pneumonitis
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Mass cytometry immunophenotyping data of two-week-old mouse pups' spleens depleted of maternal cells
Open the record for dataset details and reuse information.
Deep immunophenotyping reveals endometriosis is marked by dysregulation of the mononuclear phagocytic system in endometrium and peripheral blood
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NanoString dataset for study: Dynamic changes in the NK-, Neutrophil-, and B-cell immunophenotypes relevant in high metastatic risk post neoadjuvant chemotherapy–resistant early breast cancers
<p>Pre-processed DSP and mRNA abundance datasets used in this study.</p>
High risk clear cell renal cell carcinoma microenvironments contain protumour immunophenotypes lacking specific immune checkpoints.
<p>Final Seurat file (rds) produced from the immune cell analysis performed in "<strong>High risk clear cell renal cell carcinoma microenvironments contain protumour immunophenotypes lacking specific immune checkpoints</strong>.<em><strong>"</strong></em></p>
Nodule IMmunophenotyping Biomarker for Lung Cancer Early Diagnosis Study
ClinicalTrials.gov study NCT05432739. IPD Sharing: Not stated. Countries: 1. Publications: 21.
Immunophenotyping From Blood of Patients Suffering From Chronic Degenerating Joint Diseases and Receiving LDRT
ClinicalTrials.gov study NCT02653079. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Immunophenotyping Assessment in a COVID-19 Cohort
ClinicalTrials.gov study NCT04378777. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Treatment of Immune-related Adverse Events Refractory to Standard Therapy and Associated Changes in Immunophenotype
ClinicalTrials.gov study NCT05700565. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Changes in Gene Transcription and Immunophenotypes Following Mepolizumab Treatment for Asthma
ClinicalTrials.gov study NCT05002621. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Immunophenotyping From Blood of Patients With Malignant Gliomas
ClinicalTrials.gov study NCT02022384. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Prognostic Interest of Leucocyte Immunophenotyping During the Acute Phase of Sepsis
ClinicalTrials.gov study NCT01995448. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Lymphocyte Immunophenotyping in Common Variable Immunodeficiency
ClinicalTrials.gov study NCT01196702. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Immunophenotyping of Melanoma Patients on Treatment With Pembrolizumab
ClinicalTrials.gov study NCT02909348. IPD Sharing: NO. Countries: 1. Publications: 1.
Multi-modality Imaging & Immunophenotyping of COVID-19 Related Myocardial Injury
ClinicalTrials.gov study NCT04412369. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Immunophenotyping and Xist Gene in AML
ClinicalTrials.gov study NCT04288739. IPD Sharing: UNDECIDED. Countries: 1. Publications: 9.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.