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183 results for “Infant development”
Infants on the Move: Bibliometric Analyses of Observational versus Digital Means of Screening Infant Development
<p>Datasets, High Resolution Images and Video tutorials for Bibliometric use on neonatal General Movements Assessment</p> <p>Neurodevelopmental disorder diagnoses have increased significantly over the years, though the average age of detection is 4.5 years old. This delay is partly due to reliance on social-communication criteria. These criteria require a level of maturation that takes much longer than scaffolding elements of neuromotor control. Early components of neurodevelopment include early evolution of reflexes, development of interactions between central pattern generators and cortical structures, maturation of intentional movements and their overall sensation. Such elements have been studied in General Movement Assessment (GMA) using observational means, but the last two decades have seen a surge in digital tools (biosensors, video-based pose estimation and algorithms) that permit non-invasive tracking of newborns’ movements. Despite their importance, these tools are not yet broadly used. In this work, using CiteSpace, VOSViewer and SciMAT software, we investigate the evolution of the literature on GMA and the methods in use today, to estimate how digital techniques are being adopted. To that end, we created maps of key word co-occurrence networks, co-author networks, document co-citation analysis and strategic diagrams of 295 publications based on a search in the Web of Science, Dimensions and SCOPUS databases for: ‘general movement assessment’ OR ‘general movements assessment’. The nodes on the maps were categorized by size, cluster groups and year of publication. We found that the state-of-the-art methodology to diagnose neurodevelopmental disorders still relies heavily on observation. Several groups in classical GMA research have branched out to incorporate new techniques, but few groups have adopted digital means. We report on additional analyses of methods and biosensors usage and propose that combining traditional clinical observation criteria with digital means may allow earlier diagnoses and interventional therapies for infants.</p>
A longitudinal study of motor and cognitive development in infants with congenital idiopathic clubfoot.
<p>Dataset of A longitudinal study of motor and cognitive development in infants with congenital idiopathic clubfoot.</p>
Data from: Hair and plasma cortisol throughout the first three years of development in infant rhesus macaques, Macaca mulatta
<p>Cortisol expression has been demonstrated to have variation across development in rhesus macaques (Macaca mulatta). There exists contradictory evidence for the nature of this change, and age at which it occurs, across biological sample types. Consequently, we lack a cohesive understanding for cortisol concentrations across the development of a major human health translational model. We examined hair cortisol concentrations over the first three years of life for 49 mother-reared infant macaques from mixed-sex outdoor units at the California National Primate Research Center. For 48 of these subjects at infancy, one year, and two years, we obtained plasma cortisol samples for: response to a stressor, adjustment to prolonged stress, and response to dexamethasone injection. Hair cortisol concentrations decreased dramatically between three and ten months, followed by relative stability up to the final sampling event at around 34 months of age. Plasma cortisol showed within-year consistency, and consistency between infancy and year one. We document variability in the infant plasma cortisol samples, especially in percent change between samples one and two. Our plasma cortisol results indicate that infants possess the physiological capacity to effectively inhibit the release of cortisol when stimulated, as effectively as later responses in juveniles. Age-related changes in hair cortisol parallel findings indicating a large decline in the weeks following postparturation.</p>
Impact of maternal obesity on the gestational metabolome and infant metabolome, brain, and behavioral development in rhesus macaques
<p>Maternal gestational obesity is associated with elevated risks for neurodevelopmental disorder, including autism spectrum disorder. However, the mechanisms by which maternal adiposity influences fetal developmental programming remain to be elucidated. We aimed to understand the impact of maternal obesity on the metabolism of both pregnant mothers and their offspring, as well as on metabolic, brain, and behavioral development of offspring by utilizing metabolomics, protein, and behavioral assays in a non-human primate model. We found that maternal obesity was associated with elevated inflammation and significant alterations in metabolites of energy metabolism and one-carbon metabolism in maternal plasma and urine, as well as in placenta. Infants born to obese mothers were significantly larger at birth compared to those born to lean mothers. Additionally, they exhibited significantly reduced novelty preference and significant alterations in their emotional response to stress situations. These changes coincided with differences in phosphorylation of enzymes in the brain mTOR signaling pathway between infants born to obese and lean mothers and correlated with the concentration of maternal plasma betaine during pregnancy. In summary, gestational obesity significantly impacted the infant systemic and brain metabolome and adaptive behaviors.</p>
Infant Gray Matter Development
<p>Source data associated with Infant gray matter development project.</p> <p>All source data and codes files are also available on Github: https://github.com/VPNL/babies_graymatter</p>
Calorie restriction and pravastatin administration during pregnancy in obese rhesus macaques modulates maternal and infant metabolism and infant brain and behavioral development
<p>Maternal obesity has been associated with a higher risk of pregnancy-related complications in mothers and offspring; however, effective interventions have not yet been developed. We tested two common interventions, calorie restriction and pravastatin administration, during pregnancy in a rhesus macaque model with the hypothesis that these interventions would normalize metabolic dysregulation in pregnant mothers leading to an improvement in infant metabolic and cognitive/social development. A total of 19 obese mothers were assigned to either one of the two intervention groups (n=5 for calorie restriction; n=7 for pravastatin) or an obese control group (n=7) with no intervention, and maternal gestational samples and postnatal infant samples were compared with lean control mothers (n=6). Gestational calorie restriction normalized one-carbon metabolism dysregulation in obese mothers but altered energy metabolism in their offspring. Although administration of pravastatin during pregnancy tended to normalize blood cholesterol in the mothers, it potentially impacted the gut microbiome and kidney function of their offspring. In the offspring, both calorie restriction and pravastatin administration during pregnancy tended to normalize the activity of AMPK in the brain at 6 months, and while results of the Visual Paired-Comparison test, which measures infant recognition memory, were not significantly impacted by either of the interventions, gestational pravastatin administration, but not calorie restriction, tended to normalize anxiety assessed by the Human Intruder test. Although the two interventions tested in a non-human primate model led to some improvements in metabolism and/or infant brain development, negative impacts were also found in both mothers and infants. Our study emphasizes the importance of assessing gestational interventions for maternal obesity on both maternal and offspring long-term outcomes.</p>
Dataset underlying the paper Generating variability from motor primitives during infant locomotor development
<p>EMG data after basic preprocessing</p> <p>Each file is a matrix of M colomns and S*T raws with :</p> <p>M = number of muscles (from m1 to m10: right Rectus Femoris, left Rectus Femoris, right Tibialis Anterior, left Tibialis Anterior, right Biceps Femoris, left Biceps Femoris, right Soleus, left Soleus, right Gluteus Medius, left Gluteus Medius).</p> <p>S = number of steps (specific to each file)</p> <p>T = number of time points per step (always equals to 200)</p> <p> </p> <p>File names are ordered as follows:</p> <p>inputMat_S{subjectnumber}_C{conditionnumber}_a{agenumber}_200bins_10muscles</p> <p>subject number car take values between 1 and 18</p> <p>condition number can take the following values: 1 for stepping on a treadmill, 2 for stepping overground, 4 for kicking and 5 for walking </p> <p>age number can take the following values: 1 for around birth, 2 for around three months, 4 for around walking onset</p>
Growth and Microbiome Development in Very Low Birth Weight Infants Fed Primarily Mother's Own Milk vs. Donor Human Milk
ClinicalTrials.gov study NCT02573779. IPD Sharing: Not stated. Countries: 1. Publications: 29.
Lactose-free Milk in Infants With Acute Diarrhea in a Developing Country
ClinicalTrials.gov study NCT02246010. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Reducing Maternal Depression and Promoting Infant Social-Emotional Health & Development
ClinicalTrials.gov study NCT03464630. IPD Sharing: NO. Countries: 1. Publications: 3.
Targeting Human Milk Fortification to Improve Preterm Infant Growth and Brain Development
ClinicalTrials.gov study NCT03977259. IPD Sharing: NO. Countries: 1. Publications: 1.
Early Infant Micronutrition and Development
ClinicalTrials.gov study NCT05005897. IPD Sharing: YES. Countries: 1. Publications: 10.
Is mere exposure enough? the effects of bilingual environments on infant cognitive development
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Calorie restriction and pravastatin administration during pregnancy in obese rhesus macaques modulates maternal and infant metabolism and infant brain and behavioral development
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Impact of maternal obesity on the gestational metabolome and infant metabolome, brain, and behavioral development in rhesus macaques
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Data from: Hair and plasma cortisol throughout the first three years of development in infant rhesus macaques, Macaca mulatta
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The early development of infant siblings of children with autism spectrum disorder: Characteristics of sibling interactions
<p>Dataset associated with the paper "The early development of infant siblings of children with autism spectrum disorder: Characteristics of sibling interactions; Bontinck, C., Warreyn, P., Van der Paelt, S., Demurie, E., & Roeyers, H."</p>
Creating a Calmer NICU: Optimizing Growth and Brain Development in Preterm Infants
ClinicalTrials.gov study NCT04911452. IPD Sharing: NO. Countries: 1. Publications: 5.
Effects of Fat-soluble Vitamins Supplementation on Common Complications and Neural Development in Very Low Birth Weight Infants
ClinicalTrials.gov study NCT03876704. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Developing Advanced MRI Methods for Detecting the Impact of Nutrients on Infant Brain Development
ClinicalTrials.gov study NCT02058225. IPD Sharing: NO. Countries: 1. Publications: 3.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.