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991 results for “Inflammatory response”
Inflammatory Responses in the Placenta upon SARS-CoV-2 Infection Late in Pregnancy - IHC data
<p>SARS-CoV-2 infection during pregnancy does not affect the large majority of neonates but presents an increased risk for adverse pregnancy outcome. The effects of SARS-CoV-2 of its recently identified variants on placental function are not well understood. In this study, we investigated the impact of late gestational SARS-CoV-2 infection on the placenta.</p> <p>This dataset of is comprised of 897 images of classic immunohistochemistry for 3 markers in placenta from COVID-19 patients and controls.</p> <p><strong>A full description of the tissues, markers, and donors is available in the metadata.csv file.</strong></p>
Fig 2 in Docosahexaenoic Acid (DHA) Reduces LPSInduced Inflammatory Response Via ATF3 Transcription Factor and Stimulates Src/ Syk Signaling-Dependent Phagocytosis in Microglia
<p>Proteome profiler arrays (A and B) and expression of ATF3 gene (C) in microglia. Representative array membranes (A) and the relative levels of cytokines and chemokines (B) in microglia preincubated with 20 μM DHA and next treated with 10 ng/ml LPS.</p>
Fig 1 in Docosahexaenoic Acid (DHA) Reduces LPSInduced Inflammatory Response Via ATF3 Transcription Factor and Stimulates Src/ Syk Signaling-Dependent Phagocytosis in Microglia
<p>Viability of microglia incubated with various concentration of DHA for 12 h (A) and LPS for 2.5 h (B). Viability of microglia incubated with 20 μM DHA followed by 10 ng/ ml LPS treatment (C).</p>
Meta-analysis defines predominant shared microbial responses in various diseases and a specific inflammatory bowel disease signal
<p>Datasets and analysis notebooks for recreating the analysis described in the paper.</p> <p>biom tables of the original datasets used in the meta-analysis are not included due to privacy issues. Instead, we include the biom table containing the NRMD for each study/ASV</p> <p>Updated data and notebooks can also be found at the github page: </p> <p><a href="https://github.com/amnona/paper-metaanalysis">https://github.com/amnona/paper-metaanalysis</a></p> <p>NOTE: files here are provided in a per-directory .zip file in order to preserve internal directory structure.</p> <p> </p>
Raw Data for the article: Klebsiella pneumoniae Lipopolysaccharides Serotype O2afg Induce Poor Inflammatory Immune Responses Ex Vivo
<p>Currently, <em>Klebsiella pneumoniae</em> is a pathogen of clinical relevance due to its plastic ability of acquiring resistance genes to multiple antibiotics. During <em>K. pneumoniae</em> infections, lipopolysaccharides (LPS) play an ambiguous role as they both activate immune responses but can also play a role in immune evasion. The LPS O2a and LPS O2afg serotypes are prevalent in most multidrug resistant <em>K. pneumoniae</em> strains. Thus, we sought to understand if those two particular LPS serotypes were involved in a mechanism of immune evasion. We have extracted LPS (serotypes O1, O2a and O2afg) from <em>K. pneumoniae</em> strains and, using human monocytes ex vivo, we assessed the ability of those LPS antigens to induce the production of pro-inflammatory cytokines and chemokines. We observed that, when human monocytes are incubated with LPS serotypes O1, O2a or O2afg strains, O2afg and, to a lesser extent, O2a but not O1 failed to elicit the production of pro-inflammatory cytokines and chemokines, which suggests a role in immune evasion. Our preliminary data also shows that nuclear translocation of NF-κB, a process which regulates an immune response against infections, occurs in monocytes incubated with LPS O1 and, to a smaller extent, with LPS O2a, but not with the LPS serotype O2afg. Our results indicate that multidrug resistant <em>K. pneumoniae</em> expressing LPS O2afg serotypes avoid an initial inflammatory immune response and, consequently, are able to systematically spread inside the host unharmed, which results in the several pathologies associated with this bacterium.</p>
Inflammatory responses induced by the monophasic variant of Salmonella typhimurium in pigs play a role in the high shedder phenotype and fecal microbiota composition
<p>Pigs infected with <em><span>Salmonella</span></em> may excrete large amounts of <em><span>Salmonella</span></em>, increasing the risk of spread of this pathogen in the food chain. Identifying <em><span>Salmonella</span></em> high shedder pigs is therefore required to mitigate this risk. We analyzed immune-associated markers and composition of the gut microbiota in specific-pathogen-free pigs presenting different shedding levels after an oral infection with <span>Salmonella</span>. Immune response was studied through total blood cell counts, production of anti-<em><span>Salmonella</span></em> antibodies and cytokines, and gene expression quantification. Total <em><span>Salmonella</span></em> shedding for each pig was estimated and hierarchical clustering was used to cluster pigs into high, intermediate, and low shedders. Gut microbiota compositions were assessed using 16S rRNA microbial community profiling. Comparisons were made between control and inoculated pigs, then between high and low shedders pigs. Prior to infection, high shedders had similar immunological profiles compared to low shedders. As soon as 1 day postinoculation (dpi), significant differences in the cytokine production level and on the expression level of several host genes related to a proinflammatory response were observed between high and low shedders. Infection with <em><span>Salmonella</span></em> induced an early and profound remodeling of the immune response in all pigs, but the intensity of the response was stronger in high shedders. In contrast, low shedders seroconverted earlier than high shedders. Just after induction of the proinflammatory response (at 2 dpi), some taxa of the fecal microbiota were specific to the shedding phenotypes. This was related to the enrichment of several functional pathways related to anaerobic respiration in high shedders. In conclusion, our data show that the immune response to <em><span>Salmonella</span></em> modifies the fecal microbiota and subsequently could be responsible for shedding phenotypes. Influencing the gut microbiota and reducing intestinal inflammation could be a strategy for preventing <em><span>Salmonella</span></em> high shedding in livestock.</p>
Molecular profiling of sponge deflation reveals an ancient relaxant-inflammatory response
<p>A hallmark of animals is the coordination of whole-body movement. Neurons and muscles are central to this, yet coordinated movements also exist in sponges that lack these cell types. Sponges are sessile animals with a complex canal system for filter-feeding. They undergo whole-body movements resembling “contractions'' that lead to canal closure and water expulsion. Here, we combine 3D optical coherence microscopy, pharmacology, and functional proteomics to elucidate anatomy, molecular physiology, and control of these movements. We show that they are driven by the relaxation of actomyosin stress fibers in epithelial canal cells, which leads to whole-body deflation via collapse of the incurrent and expansion of the excurrent system, controlled by an Akt/NO/PKG/A pathway. A concomitant increase in reactive oxygen species and secretion of proteinases and cytokines indicate an inflammation-like state reminiscent of vascular endothelial cells experiencing oscillatory shear stress. This suggests an ancient relaxant-inflammatory response of perturbed fluid-carrying systems in animals.</p> <p>File descriptions:</p> <ul> <li>pharma_*.avi: Exemplary videos for pharmacological treatments of Spongilla <em>lacustris</em>, related to Fig. 2</li> <li>OCM_tomographic_scan: 2D scan through an unsegmented sponge body. First a x-z scan, afterwards a x-y scan. </li> <li>ink_treatment_suppl_figS3.mov: Video of ink treated <em>Spongilla lacustris</em> specimen, related to Fig. S3</li> <li>S_lacustris_annotations_emapper: EggNOG mapper (v2.1.9) results used for GO term enrichment analysis</li> <li>S_lacustris_proteome: Proteome file used as database for proteomic searches</li> <li>S_lacustris_scRNAseq.h5ad: file containing scRNAseq and cell type information of <em>Spongilla lacustris.</em> </li> <li>Suppl_file_*.xlsx: Tables of proteomics (TPP, phophoproteomics, secretomics) results</li> </ul>
Modulation of the Inflammatory Response in Bariatric Surgery
ClinicalTrials.gov study NCT06915558. IPD Sharing: NO. Countries: 1. Publications: 13.
A Study to Evaluate the Dose Response Based on the Efficacy, Safety and Tolerability of Bimekizumab in Subjects With Active Psoriatic Arthritis Which is a Type of Inflammatory Arthritis
ClinicalTrials.gov study NCT02969525. IPD Sharing: Not stated. Countries: 6. Publications: 3.
Variability in Response to Non-steroidal Anti-inflammatory Drugs
ClinicalTrials.gov study NCT02502006. IPD Sharing: Not stated. Countries: 1. Publications: 2.
SP16 Inflammatory Response Inhibition Trial
ClinicalTrials.gov study NCT04225533. IPD Sharing: NO. Countries: 1. Publications: 1.
Effect IV Ibuprofen and Inflammatory Responses
ClinicalTrials.gov study NCT01938040. IPD Sharing: NO. Countries: 1. Publications: 1.
Follow-up of Inflammatory Responses and Multiorgan Outcomes FoLlowing Neonatal Brain injurY
ClinicalTrials.gov study NCT04816331. IPD Sharing: NO. Countries: 1. Publications: 25.
Clinical Trial to Assess Pharmacodynamic Effects on Segmental Endotoxin Induced Inflammatory Response of BI 1026706 Versus Placebo
ClinicalTrials.gov study NCT02657408. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Clinical Outcomes and Inflammatory Responses in Viral vs. Bacterial Sepsis
ClinicalTrials.gov study NCT06491966. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
A Retrospective Observational Study to Assess the Impact of Co-morbidities on Treatment Response in Inflammatory Bowel Disease
ClinicalTrials.gov study NCT02861118. IPD Sharing: YES. Countries: 1. Publications: 1.
An Exploratory Study to Investigate the Inflammatory Response During a Cold Sore Episode
ClinicalTrials.gov study NCT01653509. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Rosuvastatin Response in Healthy Subjects: Potential Mechanisms of Anti-inflammatory Effects
ClinicalTrials.gov study NCT00874757. IPD Sharing: NO. Countries: 1. Publications: 5.
Does Propranolol Attenuate Inflammatory Responses to a Psychological Stressor?
ClinicalTrials.gov study NCT02972554. IPD Sharing: NO. Countries: 1. Publications: 28.
Pilot Study on the Effect of Dexmedetomidine on Inflammatory Responses in Patients Undergoing Lumbar Spinal Fusion
ClinicalTrials.gov study NCT01377623. IPD Sharing: YES. Countries: 1. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.