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311 results for “Innate immune response”
Trade-off between photo-symbiosis and innate immunity influences cnidarian’s response to pathogenic bacteria
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Multi-omics analysis of innate and adaptive responses to BCG vaccination reveals epigenetic cell states that predict trained immunity
<p>This repository contains personal immune profiles of 323 healthy individuals (300BCG) subjected to Bacillus Calmette-Guérin (BCG) with blood samples collected immediately before (day 0), and 14 and 90 days after the vaccination. The personal immune profiles comprise:</p> <ul> <li>immune cell concentrations measured with flow cytometry and a hematology analyzer</li> <li>plasma concentrations of 73 circulating inflammatory markers</li> <li>30 measurements of cytokine and lactate production capacity of peripheral blood mononuclear cells (PBMCs) in response to four microbial stimuli (Candida albicans, Escherichia coli lipopolysaccharide [LPS], Staphylococcus aureus, Mycobacterium tuberculosis).</li> </ul> <p>Visit <a href="http://300BCG.bocklab.org/">http://300BCG.bocklab.org/</a> to learn more.</p>
Data from: Thermoregulatory costs of the innate immune response are modulated by winter food availability in a small passerine
<p>1. In winter, a challenge to the immune system could pose a major energetic trade-off for small endotherms, whereby increasing body temperature (<em>T</em><sub>b</sub>; i.e. eliciting fever) may be beneficial to fight off invading pathogens yet incur a cost for vital energy-saving mechanisms.</p> <p>2. Having previously shown that the availability and acquisition of energy, through manipulation of food predictability, influence the depth of rest-phase hypothermia in a wild bird in winter, we expected that the nocturnal thermoregulatory component of the acute-phase immune response would also be modulated by food availability.</p> <p>3. By manipulating winter food availability in the wild for great tits, <em>Parus major</em>, we created an area offering a "predictable" and constant supply of food at feeding stations, while an unmanipulated area was subject to naturally "unpredictable" food. Birds were subject to an immune challenge shortly after dusk, and the thermoregulatory response was quantified via continuous recording of nocturnal <em>T</em><sub>b</sub>, using subcutaneous thermo-sensitive transponders.</p> <p>4. In response to immune challenge, all birds increased <em>T</em><sub>b</sub> above the level maintained prior to immune challenge (i.e. baseline). However, birds experiencing a naturally unpredictable food supply elevated <em>T</em><sub>b</sub> more than birds with access to predictable food resources, during the period of expected peak response and for the duration of the night. Furthermore, "unpredictable-food" females took longer to return to baseline <em>T</em><sub>b</sub>. Assuming baseline nocturnal <em>T</em><sub>b</sub> reflects an individual's optimum, based on their available energy budget, the metabolic cost of eliciting an acute-phase response for "unpredictable-food" birds was more than double that of "predictable-food" birds. The absence of differences in absolute <em>T</em><sub>b</sub> during the peak response could support the idea of an optimal <em>T</em><sub>b</sub> for immune system activation. Alternatively, "predictable-food" birds could have acquired tolerance to endotoxin as a result of using feeding stations, thus affording them reduced costs associated with a smaller <em>T</em><sub>b</sub> increase.</p> <p>5. These findings shed new light on the trade-offs associated with food acquisition, thermoregulation and immune function in small-bodied endotherms. This knowledge is of increasing importance, given the predicted elevated pathogen risks associated with changes in climate and anthropogenic activities.</p>
The Impact of Aspirin Dose Modification on the Innate Immune Response - Will Lower Dose Aspirin Therapy Reduce the Response to Endotoxin
ClinicalTrials.gov study NCT03869268. IPD Sharing: Not stated. Countries: 1. Publications: 36.
Data from: Thermoregulatory costs of the innate immune response are modulated by winter food availability in a small passerine
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Data from: Concholepas concholepas Ferritin H-like subunit (CcFer): molecular characterization and single nucleotide polymorphism associated to innate immune response
Ferritin has been shown as the principal protein of iron storage and iron detoxification, playing a pivotal role for the cellular homeostasis in living organisms. However, recent studies in marine invertebrates have suggested its association with innate immune system. In the present study, one Ferritin subunit was identified from the gastropod Concholepas concholepas (CcFer), which was fully characterized by Rapid Amplification of cDNA Ends technique. Simultaneously, a challenge test was performed to evaluate the immune response against Vibrio anguillarum. The full length of cDNA Ccfer was 1,030 bp, containing 513 bp of open reading frame that encodes 170 amino acid peptides, which was similar to the Ferritin-H subunit described in vertebrates. Untranslated Regions (UTRs) were identified with a 5'UTR of 244 bp that contains iron responsive element (IRE), and a 3'UTR of 273 pb. The predicted molecular mass of deduced amino acid of CcFer was 19.66 kDa and isoelectric point of 4.92. Gene transcription analysis revealed that CcFer increases against infections with V. anguillarum, showing a peak expression at 6 hours post-infection. Moreover, a single nucleotide polymorphism was detected at -64 downstream 5'UTR sequence (SNP-64). Quantitative real time analysis showed that homozygous mutant allele (TT) was significantly associated with higher expression levels of the challenged group compared to wild (CC) and heterozygous (CT) variants. Our findings suggest that CcFer is associated to innate immune response in C. concholepas and that the presence of SNPs may involve differential transcriptional expression of CcFer.
Innate immune responses against the mRNA component of mRNA vaccine promote cellular immunity through IFN-β at the injection site
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Send-In Sample Collection for Comprehensive Analyses of Innate and Adaptive Immune Responses During Acute COVID-19 and Convalescence
ClinicalTrials.gov study NCT04582903. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Characterization of the Innate Immune Response in Healthy NIH Employees at Baseline and After Immunization With the H1N1 Vaccine
ClinicalTrials.gov study NCT00995527. IPD Sharing: Not stated. Countries: 1. Publications: 3.
The Effects of Oral Dipyridamole Treatment on the Innate Immune Response During Human Endotoxemia
ClinicalTrials.gov study NCT01091571. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Comparison of Innate Immune Responses Induced by Allergy Immunotherapy (AIT) With Different Adjuvants
ClinicalTrials.gov study NCT04104828. IPD Sharing: NO. Countries: 1. Publications: 1.
Response to Tregs in Innate Immunity Receptor LRP1 (CD91) and Tregs in Periferic Blood Mononuclear Cells in Patients With Non-segmentary Vitiligo
ClinicalTrials.gov study NCT03249064. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
In Vivo Effects of C1-esterase Inhibitor on the Innate Immune Response During Human Endotoxemia - VECTOR II
ClinicalTrials.gov study NCT01766414. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Tetracycline to Limit the Innate Immune Response in Acute Respiratory Distress Syndrome
ClinicalTrials.gov study NCT04079426. IPD Sharing: NO. Countries: 1. Publications: 1.
Effect of Gutamine Administration in the Innate Immune System Response in ICU Patients.
ClinicalTrials.gov study NCT01250080. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Concholepas concholepas Ferritin H-like subunit (CcFer): molecular characterization and single nucleotide polymorphism associated to innate immune response
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Exposure to artificial light at night alters innate immune response in wild great tit nestlings
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Machine Learning-assisted immunophenotyping of peripheral blood identifies innate immune cells as best predictor of response to induction chemo-immunotherapy in head and neck squamous cell carcinoma – knowledge obtained from the CheckRad-CD8 trial
<p>Raw cell counts from peripheral blood immune phenotyping across individual patients.</p>
Infection of HSV1 in innate lymphoid cells leads to alienation of the mechanism of T/B-cell activation in the adaptive immune response-image
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A Study to Document the Effect of Petrolatum on Innate Immune Responses in the Skin
ClinicalTrials.gov study NCT02338076. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.