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14
datasets available to search
ShareScore release 0.9.0
Dataset results
14 results for “Intracellular pathogens”
Mass spectrometry data from: Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens
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data for Pathogen-specific isotope tracing approach reveals metabolic activities and fluxes of intracellular Salmonella
<p>Contains the results of the MCMC sampling (i.e. fluxes) as well as the simulated MS measurements.</p> <p> </p>
3D reconstructions of parasite development and the intracellular niche of the microsporidian pathogen E. intestinalis
<p>Source data for "3D reconstructions of parasite development and the intracellular niche of the microsporidian pathogen <i>E. intestinalis</i>".</p><p>There are four separate zip folders<br>1. <i>E. intestinalis</i> infectivity in Vero cells: Source data for Figures 1B-D</p><p>2. Mitochondrial Fragmentation: Source data for Figures 6C-D and Supplementary Figures 6D-E</p><p>3. Mitochondrial Fragmentation: Source data for Figures 6E-F</p><p>4. PV localization: Source data for Supplementary Figure 6B</p><p> </p>
Data from: Diverse mechanisms of metaeffector activity in an intracellular bacterial pathogen, Legionella pneumophila
Pathogens deliver complex arsenals of translocated effector proteins to host cells during infection, but the extent to which these proteins are regulated once inside the eukaryotic cell remains poorly defined. Among all bacterial pathogens, Legionella pneumophila maintains the largest known set of translocated substrates, delivering over 300 proteins to the host cell via its Type IVB, Icm/Dot translocation system. Backed by a few notable examples of effector–effector regulation in L. pneumophila, we sought to define the extent of this phenomenon through a systematic analysis of effector–effector functional interaction. We used Saccharomyces cerevisiae, an established proxy for the eukaryotic host, to query > 108,000 pairwise genetic interactions between two compatible expression libraries of ~330 L. pneumophila‐translocated substrates. While capturing all known examples of effector–effector suppression, we identify fourteen novel translocated substrates that suppress the activity of other bacterial effectors and one pair with synergistic activities. In at least nine instances, this regulation is direct—a hallmark of an emerging class of proteins called metaeffectors, or "effectors of effectors". Through detailed structural and functional analysis, we show that metaeffector activity derives from a diverse range of mechanisms, shapes evolution, and can be used to reveal important aspects of each cognate effector's function. Metaeffectors, along with other, indirect, forms of effector–effector modulation, may be a common feature of many intracellular pathogens—with unrealized potential to inform our understanding of how pathogens regulate their interactions with the host cell.
Data from: Diverse mechanisms of metaeffector activity in an intracellular bacterial pathogen, Legionella pneumophila
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Mobile-CRISPRi as a tool for genetic manipulation in the intracellular pathogen Piscirickettsia salmonis
GEO Series GSE309378. Piscirickettsia salmonis. 6 samples. Type: Expression profiling by high throughput sequencing.
Human giant GTPase GVIN1 forms an antimicrobial coatomer around the intracellular bacterial pathogen Burkholderia thailandensis
GEO Series GSE288527. Homo sapiens. 40 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic Analysis of the Intracellular Pathogen Response (IPR)
GEO Series GSE118400. Caenorhabditis elegans. 15 samples. Type: Expression profiling by high throughput sequencing.
Temporal Gene Expression Analysis of the intracellular pathogen Brucella melitensis following bovine Peyer's patch infection.
GEO Series GSE89053. Brucella melitensis bv. 1 str. 16M; Brucella melitensis. 44 samples. Type: Expression profiling by array.
Multiple levels of gene regulation mediate differentiation of the intracellular pathogen Leishmania
GEO Series GSE21936. Leishmania donovani; Leishmania infantum JPCM5. 16 samples. Type: Expression profiling by array.
Conservation of intracellular pathogenic strategy among distantly related Cryptococcal species
GEO Series GSE112668. Mus musculus. 18 samples. Type: Expression profiling by array.
Diverse intracellular pathogens activate Type III Interferon expression from peroxisomes
GEO Series GSE56783. Homo sapiens. 6 samples. Type: Expression profiling by array.
Regulatory (pan-)genome of an obligate intracellular pathogen in the PVC superphylum
GEO Series GSE68059. Waddlia chondrophila. 10 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Characterization of the oxyR mutant in the intracellular pathogen Legionella pneumophila
GEO Series GSE87029. Legionella pneumophila subsp. pneumophila str. Philadelphia 1. 12 samples. Type: Expression profiling by array.
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.