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62 results for “Intranasal administration”
Data from: Intranasal administration of dantrolene increased brain concentration and duration
<p>Dantrolene has been demonstrated to be neuroprotective for multiple neurodegenerative diseases. However, dantrolene's limited penetration into the CNS hampers its effectiveness as a neuroprotective agent. Here, we studied whether the intranasal administration of dantrolene provided better penetration into the brain than the commonly used oral approach. C57BL/6<b> </b>mice, aged 2-4 months, received a single dose of either intranasal or oral dantrolene (5mg/kg). Inhibition of dantrolene clearance from the brain was examined by co-administration with P-gp/BCRP inhibitors, nimodipine or elacridar. The concentration of dantrolene in the brain and plasma was measured at 10, 20, 30, 50, 70, 120, 150 and 180 minutes after administration. Separate cohorts of mice were given intranasal dantrolene (5mg/kg) or vehicle, 3 times/ week, for either 3 weeks or 4 months, to examine potential adverse side effects on olfaction and motor coordination, respectively.</p> <p>We found that Dantrolene concentrations were sustained in the brain after intranasal administration for 180 min, while concentrations fell to zero at 120 min for oral administration. <span>Chronic use of intranasal dantrolene did not impair olfaction or motor function in these mice. Blood brain barrier pump inhibitors</span> did not further increase dantrolene peak concentrations in the brain. Our results suggested that<i> </i>Intranasal administration of dantrolene is an effective route to increase its concentration and duration in the brain compared to the oral approach, without any obvious side effects on olfaction or motor function.</p>
Efficacy and Safety Study of Intranasal Administration of 100, 200, and 400 μg of Fluticasone Propionate Using a Novel Bi-directional Device
ClinicalTrials.gov study NCT01624662. IPD Sharing: YES. Countries: 1. Publications: 3.
Efficacy Study in Allergic Rhinitis Patients After Intranasal Administration of AZD8848
ClinicalTrials.gov study NCT01185080. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study Evaluating the Efficacy and Safety of Intranasal Administration of 100, 200, and 400 μg of Fluticasone Propionate Twice a Day (BID) Using a Novel Bi Directional Device in Subjects With Bilateral
ClinicalTrials.gov study NCT01622569. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Volumes of Administration for Intranasal Midazolam
ClinicalTrials.gov study NCT01948908. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Intranasal Administration of Neuropeptide Y in Healthy Male Volunteers
ClinicalTrials.gov study NCT00748956. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Data from: Intranasal administration of dantrolene increased brain concentration and duration
Open the record for dataset details and reuse information.
Pharmacokinetics of Nalbuphine After Intravenous and Intranasal Administration in Infants
ClinicalTrials.gov study NCT03059511. IPD Sharing: YES. Countries: 1. Publications: 1.
A Study to Evaluate the Effects of a Single-Dose and Repeat-Administration of Intranasal Esketamine on On-Road Driving in Participants With Major Depressive Disorder
ClinicalTrials.gov study NCT02919579. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Intranasal Oxytocin Administration on Social Influence Effects on Pain
ClinicalTrials.gov study NCT03060031. IPD Sharing: UNDECIDED. Countries: 1. Publications: 35.
A Study to Investigate the Safety and Pharmacodynamics of Repeat Intranasal Administration of the TLR7 Agonist GSK2245035 in Subjects With Respiratory Allergies
ClinicalTrials.gov study NCT01607372. IPD Sharing: YES. Countries: 1. Publications: 1.
Efficacy of Topical Lidocaine to Decrease Discomfort With Intranasal Midazolam Administration
ClinicalTrials.gov study NCT02396537. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Effects of Intranasal Administration of Oxytocin in Adults With Prader-Willi Syndrome
ClinicalTrials.gov study NCT02804373. IPD Sharing: NO. Countries: 1. Publications: 1.
Buccal Versus Intranasal Route of Administration of Midazolam Spray in Behavior Management of Pre-School Patients
ClinicalTrials.gov study NCT04608734. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Tolerability/PoP Study in Allergic Rhinitis After Intranasal Administration of AZD8848
ClinicalTrials.gov study NCT00770003. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Study of Olanzapine After Intranasal and Intramuscular Administration
ClinicalTrials.gov study NCT06600477. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Sublingual Versus Intranasal Administration of Dexmedetomidine for Sedation of Children Undergoing Dental Treatment
ClinicalTrials.gov study NCT04237532. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Effect of Intranasal Breast Milk Administration in Preterm Infants
ClinicalTrials.gov study NCT06706115. IPD Sharing: NO. Countries: 1. Publications: 5.
A Study to Compare the Bioavailability Intranasal Administration of 200 and 400 µg or 400 µg Alone of OPTINOSE™ FLUTICASONE With 440 µg of Flovent® HFA (Fluticasone Propionate) Inhalation Aerosol (Par
ClinicalTrials.gov study NCT02266927. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Intranasal Administration of a Single Dose of Oxytocin Using a Novel Device in Healthy Adults
ClinicalTrials.gov study NCT01983514. IPD Sharing: Not stated. Countries: 1. Publications: 3.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.