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datasets available to search
ShareScore release 0.9.0
Dataset results
27 results for “Isothiocyanate”
Isothiocyanate detoxification in Delia species
<p>We provide additional data like genome sequences, gene annotation, functional annotation for D. floralis we used to generate results described in our manuscript "Mechanisms of isothiocyanate detoxification in larvae of two belowground herbivores, <em>Delia radicum </em>and<em> D. floralis</em> (Diptera: Anthomyiidae)". We also provide resluting DESeq2 counts including log2-fold changes and corresponding statistics.<br> In addition we provide intermediate results on the assembly and annotation of unmapped reads.</p>
The plant toxin 4-methylsulfinylbutyl isothiocyanate decreases herbivore performance and modulate cellular and humoral immunity
<p class="MsoNormal"><span>Insect herbivores frequently encounter plant defense molecules, but the physiological and ecological consequences for their immune systems are not fully understood. The majority of studies attempting to relate levels of plant defensive chemistry to herbivore immune responses have used natural population or species-level variation in plant defensive chemistry. Yet, this potentially confounds the effects of plant defense chemistry with other potential traits that may affect the expression of herbivore immunity such as development time and nutritional quality. We have used an artificial diet containing known quantities of a plant toxin (4-methylsulfinylbutyl isothiocyanate; 4MSOB-ITC or ITC), an isothiocyanate present in many plants in the genus <em>Brassica</em>, to explicitly explore the effects of a plant toxin on the cellular and humoral immune responses of the generalist herbivore <em>Trichoplusia ni</em> (Lepidoptera: Noctuidae) that frequently feeds on glucosinolate-containing plants. Caterpillars feeding on diets with high concentrations of ITC experienced reduced survivorship and growth rates. High concentrations of ITC suppressed the appearance of several types of hemocytes and melanization activity, which are critical defenses against parasitic Hymenoptera and microbial pathogens. In terms of </span><em><span>T. ni</span></em><span> humoral immunity, only </span><span>the antimicrobial peptide (AMP) genes <em>lebocin</em> and <em>gallerimycin </em>were significantly upregulated in caterpillars fed on diets </span><span>containing high levels of 4MSOB-ITC relative to caterpillars that were provided with ITC-free diet</span><span>. Surprisingly, challenging </span><span>caterpillars</span><span> </span><span>with a non-pathogenic strain of </span><em><span>Escherichia coli</span></em><span> resulted in the upregulation of the AMP gene <em>cecropin</em>. Feeding on high concentrations of plant toxins hindered caterpillar development and decreased cellular immunity but conferred mixed effects on humoral immunity. Our findings provide novel insights into the effects of herbivore diet composition on insect performance demonstrating the role of specific plant defense toxins that shape herbivore immunity and trophic interactions. </span></p>
Phenethyl Isothiocyanate in Preventing Lung Cancer in Smokers
ClinicalTrials.gov study NCT00691132. IPD Sharing: NO. Countries: 1. Publications: 2.
The plant toxin 4-methylsulfinylbutyl isothiocyanate decreases herbivore performance and modulate cellular and humoral immunity
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Synthetic and mechanistic study on the conjugate isothiocyanation of enones with trimethylsilyl isothiocyanate
<p>Gaussian 16 output files for all computed structures in the article "Synthetic and mechanistic study on the conjugate isothiocyanation of enones with trimethylsilyl isothiocyanate". <em>Organic & Biomolecular Chemistry</em>, <strong>2023</strong>, <em>21</em>, 9583-9590. <a title="Link to landing page via DOI" href="https://doi.org/10.1039/D3OB01710A">https://doi.org/10.1039/D3OB01710A</a></p>
Brassica Intake and Isothiocyanate Absorption
ClinicalTrials.gov study NCT02346812. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Supplementary data from: Are natural-based isothiocyanate derivatives alternative antioxidant additives used in petrochemical products?
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Moringa isothiocyanate-1 regulates Nrf2 and NF-κB Pathway in response to LPS-driven sepsis and inflammation
GEO Series GSE155738. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Effects of Phenylethyl Isothiocyanate on N-Nitrosomethylbenzylamine-induced Cytotoxicity in Rat Esophagus
GEO Series GSE6917. Rattus norvegicus. 12 samples. Type: Expression profiling by array.
Cancer prevention by phenethyl isothiocyanate (PEITC) in transgenic adenocarcinoma of the mouse prostate (TRAMP) mice
GEO Series GSE140314. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
Allyl-isothiocyanate treatment induces a complex transcriptional reprogramming including heat stress, oxidative stress and plant defense responses in Arabidopsis thaliana
GEO Series GSE81634. Arabidopsis thaliana. 12 samples. Type: Expression profiling by array.
Transcriptomic response of Xanthomonas campestris pv. campestris after exposure to allyl-isothiocyanate and indol-3 carbinol
GEO Series GSE167555. Xanthomonas campestris pv. campestris. 6 samples. Type: Expression profiling by high throughput sequencing.
Moringa isothiocyanate-1 inhibits inflammation via NF-κB pathway in skeletal muscle cells
GEO Series GSE209706. Mus. 18 samples. Type: Expression profiling by high throughput sequencing.
Gene regulation in Arabidopsis by isothiocyanates
GEO Series GSE117869. Arabidopsis thaliana. 12 samples. Type: Expression profiling by array.
Isothiocyanates and Metabolic Health
ClinicalTrials.gov study NCT05070585. IPD Sharing: NO. Countries: 1. Publications: 0.
Cancer prevention by phenethyl isothiocyanate (PEITC) in transgenic adenocarcinoma of the mouse prostate (TRAMP) mice [RNA-Seq]
GEO Series GSE140310. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Cancer prevention by phenethyl isothiocyanate (PEITC) in transgenic adenocarcinoma of the mouse prostate (TRAMP) mice [methyl-Seq]
GEO Series GSE140311. Mus musculus. 12 samples. Type: Methylation profiling by high throughput sequencing.
Study of Phenethyl Isothiocyanate in Lymphoproliferative Disorders
ClinicalTrials.gov study NCT00968461. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Phenethyl Isothiocyanate in Preventing Lung Cancer in People Who Smoke
ClinicalTrials.gov study NCT00005883. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Synergistic antibacterial mechanism of benzyl isothiocyanate and resveratrol against Staphylococcus aureus revealed by transcriptomic analysis
GEO Series GSE278127. Staphylococcus aureus. 12 samples. Type: Expression profiling by high throughput sequencing.
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