Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
6
datasets available to search
ShareScore release 0.7.1
Dataset results
6 results for “KCNQ1”
Ion permeation through a narrow cavity constriction in KCNQ1 channels, scours files of MD simulations and analysis of electrophysiological experiments.
<p>Source files of Molecular Dynamic (MD) simulations and analysis files of electrophysiology data in Igor pro software format. KCNQ1 channel pore region (G245-K354) was embedded in a lipid bilayer consisting of phosphatidylcholine phospholipids (POPC) and ion permission mechanism was analized by MD simulations using the computational electrophysiology (compEL) method implemented in GROMACS v2022.4. Ion imbalance between compartments of double-membrane system created a membrane potential of abour 300 mV which drives ion movment.</p>
Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients.
ClinicalTrials.gov study NCT04715256. IPD Sharing: YES. Countries: 1. Publications: 6.
KCNQ1 Cascade Screening
ClinicalTrials.gov study NCT03783975. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Critical Role of KCNQ1 in Human β-Cell Developmen
GEO Series GSE168245. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Haldane’s rule in the placenta: sex-biased misregulation of the Kcnq1 imprinting cluster in hybrid mice
GEO Series GSE161051. Mus musculus domesticus x Mus spretus; Mus musculus domesticus; Mus spretus. 29 samples. Type: Methylation profiling by high throughput sequencing.
KCNQ1 Antibodies for Immunotherapy of Long QT Syndrome Type 2
<p><strong>BACKGROUND</strong> Patients with long QT syndrome (LQTS) are predisposed to life-threatening arrhythmias. A delay in</p> <p>cardiac repolarization is characteristic of the disease. Pharmacotherapy, implantable cardioverter-defibrillators, and left</p> <p>cardiac sympathetic denervation are part of the current treatment options, but no targeted therapy for LQTS exists to</p> <p>date. Previous studies indicate that induced autoimmunity against the voltage-gated KCNQ1 K. channels accelerates</p> <p>cardiac repolarization.</p> <p><strong>OBJECTIVES </strong>However, a causative relationship between KCNQ1 antibodies and the observed electrophysiological effects</p> <p>has never been demonstrated, and thus presents the aim of this study.</p> <p><strong>METHODS</strong> The authors purified KCNQ1 antibodies and performed whole-cell patch clamp experiments as well as singlechannel</p> <p>recordings on Chinese hamster ovary cells overexpressing IKs channels. The effect of purified KCNQ1 antibodies</p> <p>on human cardiomyocytes derived from induced pluripotent stem cells was then studied.</p> <p><strong>RESULTS</strong> The study demonstrated that KCNQ1 antibodies underlie the previously observed increase in repolarizing IKs</p> <p>current. The antibodies shift the voltage dependence of activation and slow the deactivation of IKs. At the single-channel</p> <p>level, KCNQ1 antibodies increase the open time and probability of the channel. In models of LQTS type 2 (LQTS2) using</p> <p>human induced pluripotent stem cell-derived cardiomyocytes, KCNQ1 antibodies reverse the prolonged cardiac repolarization</p> <p>and abolish arrhythmic activities.</p> <p><strong>CONCLUSIONS</strong> Here, the authors provide the first direct evidence that KCNQ1 antibodies act as agonists on IKs</p> <p>channels. Moreover, KCNQ1 antibodies were able to restore alterations in cardiac repolarization and most importantly</p> <p>to suppress arrhythmias in LQTS2. KCNQ1 antibody therapy may thus present a novel promising therapeutic</p> <p>approach for LQTS2. </p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.