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2 results for “KPMP”
KPMP Datasets for a Reference Tissue Atlas for the Human Kidney
<p>This is the dataset for the publication of A Reference Tissue Atlas for the Human Kidney from the Kidney Precision Medicine Project (KPMP). KPMP is building a spatially-specified human kidney tissue atlas in health and disease with single-cell resolution. Here, we describe the construction of an integrated reference map of cells, pathways and genes using unaffected regions of nephrectomy tissues and undiseased human biopsies from 56 subjects. We use single-cell/nucleus transcriptomics, subsegmental laser-microdissection transcriptomics and proteomics, near-single-cell proteomics, 3-D and CODEX imaging, and spatial metabolomics to hierarchically identify genes, pathways and cells. Integrated data from these different technologies coherently identify cell types/subtypes within different nephron segments and the interstitium. These profiles describe cell-level functional organization of the kidney following its physiological functions and link cell subtypes to genes, proteins, metabolites and pathways. They further show that mRNA levels along the nephron are congruent with the subsegmental physiological activity. This reference atlas provides a framework for classification of kidney disease when multiple molecular mechanisms underlie convergent clinical phenotypes.</p>
Kidney Precision Medicine Project (KPMP) - COVID-19 Protocol
ClinicalTrials.gov study NCT05384899. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.